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The protein encoded by STK4 is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. Additionally we are shipping STK4 Antibodies (63) and STK4 Kits (3) and many more products for this protein.
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Human STK4 Protein expressed in Baculovirus infected Insect Cells - ABIN2004336
Lehtinen, Yuan, Boag, Yang, Villén, Becker, DiBacco, de la Iglesia, Gygi, Blackwell, Bonni: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. in Cell 2006
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Data indicate that two siblings with a serine/threonine kinase 4 (STK4) mutation with features of autosomal recessive (AR) hyperimmunoglobulin E syndrome and autoimmune cytopenias.
STK4 was reduced in macrophages from human hepatoma patients and was inversely associated with the levels of IRAK1, IL-6, and phospho-p65 or phospho-STAT3. Serum STK4 levels were specifically decreased in HCC patients with high levels of IL-6.
The MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis.
the kinase Mst1 (show MST1 Proteins) controls selective CCR7 (show CCR7 Proteins)-dependent functions in human mature dendritic cells.
Genetic inactivation of STK4 restores YAP1 (show YAP1 Proteins) levels, triggering cell death in hematologic malignancies.
Results indicate that changes in phosphorylation orchestrate interactions between kinases and phosphatases in Hippo (MST1 (show MST1 Proteins)/2 protein kinases) signaling, providing a putative mechanism for pathway regulation.
Inhibition of Mst1 (show MST1 Proteins) kinase activation in cardiomyocytes protects against cell hypoxia.
Under diabetogenic conditions, MST1 (show MST1 Proteins) was strongly activated in beta cells, and induced apoptosis via BIM (show BCL2L11 Proteins) upregulation, and impaired insulin (show INS Proteins) secretion via phosphorylation of PDX1 (show PDX1 Proteins).
PHLPP1 is a binding protein for Mst1 (show MST1 Proteins) and it modulates the Hippo pathway by dephosphorylating Mst1 (show MST1 Proteins) at the inhibitory Thr (show TRH Proteins)(387) of Mst1 (show MST1 Proteins).
Results indicated that Mst1 (show MST1 Proteins) might be a promising anticancer target.
Data (including data from studies in knockout/transgenic mice) suggest Mst1 (show MST1 Proteins) has functional roles in cytotoxic T-lymphocytes and in inhibition of tumor progression/size of T-cell lymphoma; Mst1 (show MST1 Proteins) may be involved in tumor immunity/immunologic surveillance.
the TLR-Mst1 (show MST1 Proteins)-Mst2 (show STK3 Proteins)-Rac (show AKT1 Proteins) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
Macrophage-specific Stk4 deletion resulted in chronic inflammation, liver fibrosis, and hepatomas in mice exposed to liver insult.
STK4 is a novel candidate biomarker for early stage pancreatic cancer.
Phosphorylation of LC3 (show MAP1LC3A Proteins) by the STK3 (show PKN1 Proteins) and STK4 is essential for autophagy.
These results identify MST2 (show STK3 Proteins), not MST1 (show MST1 Proteins), as a critical regulator of caspase (show CASP3 Proteins)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
Mst1 (show MST1 Proteins)/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1 (show MST1 Proteins)/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.
Mst1 (show MST1 Proteins) is required for Treg cells to mediate contact-dependent suppressor functions.
Thioredoxin-1 (show TXN Proteins) functions as a molecular switch to turn off the oxidative stress-induced (show SQSTM1 Proteins) activation of MST1 (show MST1 Proteins).
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
, STE20-like kinase MST1
, dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))
, kinase responsive to stress 2
, mammalian STE20-like protein kinase 1
, mammalian sterile 20-like 1
, serine/threonine-protein kinase 4
, serine/threonine-protein kinase Krs-2
, Yeast Sps1/Ste20-related kinase 3
, sterile 20-like kinase 1