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serine/threonine Kinase 4 Proteins (STK4)

The protein encoded by STK4 is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. Additionally we are shipping STK4 Antibodies (70) and STK4 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
STK4 6789 Q13043
STK4 58231 Q9JI11
Rat STK4 STK4 311622  
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Top STK4 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 16 Days
$338.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,371.50
Details
Yeast REACT_Green monkey His tag   1 mg Log in to see 56 to 66 Days
$3,377.00
Details
Yeast Primate His tag   1 mg Log in to see 56 to 66 Days
$3,377.00
Details
Yeast Primates His tag   1 mg Log in to see 56 to 66 Days
$3,377.00
Details
Yeast Primate His tag   1 mg Log in to see 56 to 66 Days
$3,377.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,377.00
Details

STK4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Top referenced STK4 Proteins

  1. Human STK4 Protein expressed in Baculovirus infected Insect Cells - ABIN2004336 : Lehtinen, Yuan, Boag, Yang, Villén, Becker, DiBacco, de la Iglesia, Gygi, Blackwell, Bonni: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. in Cell 2006 (PubMed)
    Show all 5 references for ABIN2004336

More Proteins for serine/threonine Kinase 4 (STK4) Interaction Partners

Human serine/threonine Kinase 4 (STK4) interaction partners

  1. Data indicate that two siblings with a serine/threonine kinase 4 (STK4) mutation with features of autosomal recessive (AR) hyperimmunoglobulin E syndrome and autoimmune cytopenias.

  2. STK4 was reduced in macrophages from human hepatoma patients and was inversely associated with the levels of IRAK1, IL-6, and phospho-p65 or phospho-STAT3. Serum STK4 levels were specifically decreased in HCC patients with high levels of IL-6.

  3. The MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis.

  4. the kinase Mst1 (show MST1 Proteins) controls selective CCR7 (show CCR7 Proteins)-dependent functions in human mature dendritic cells.

  5. Genetic inactivation of STK4 restores YAP1 (show YAP1 Proteins) levels, triggering cell death in hematologic malignancies.

  6. Results indicate that changes in phosphorylation orchestrate interactions between kinases and phosphatases in Hippo (MST1 (show MST1 Proteins)/2 protein kinases) signaling, providing a putative mechanism for pathway regulation.

  7. Inhibition of Mst1 (show MST1 Proteins) kinase activation in cardiomyocytes protects against cell hypoxia.

  8. Under diabetogenic conditions, MST1 (show MST1 Proteins) was strongly activated in beta cells, and induced apoptosis via BIM (show BCL2L11 Proteins) upregulation, and impaired insulin (show INS Proteins) secretion via phosphorylation of PDX1 (show PDX1 Proteins).

  9. PHLPP1 is a binding protein for Mst1 (show MST1 Proteins) and it modulates the Hippo pathway by dephosphorylating Mst1 (show MST1 Proteins) at the inhibitory Thr (show TRH Proteins)(387) of Mst1 (show MST1 Proteins).

  10. Results indicated that Mst1 (show MST1 Proteins) might be a promising anticancer target.

Mouse (Murine) serine/threonine Kinase 4 (STK4) interaction partners

  1. Studies indicate that Hippo (Hpo (show GFER Proteins); MST1 (show MST1 Proteins)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.

  2. Data (including data from studies in knockout/transgenic mice) suggest Mst1 (show MST1 Proteins) has functional roles in cytotoxic T-lymphocytes and in inhibition of tumor progression/size of T-cell lymphoma; Mst1 (show MST1 Proteins) may be involved in tumor immunity/immunologic surveillance.

  3. the TLR-Mst1 (show MST1 Proteins)-Mst2 (show STK3 Proteins)-Rac (show AKT1 Proteins) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity

  4. Macrophage-specific Stk4 deletion resulted in chronic inflammation, liver fibrosis, and hepatomas in mice exposed to liver insult.

  5. STK4 is a novel candidate biomarker for early stage pancreatic cancer.

  6. Phosphorylation of LC3 (show MAP1LC3A Proteins) by the STK3 (show PKN1 Proteins) and STK4 is essential for autophagy.

  7. These results identify MST2 (show STK3 Proteins), not MST1 (show MST1 Proteins), as a critical regulator of caspase (show CASP3 Proteins)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.

  8. Mst1 (show MST1 Proteins)/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1 (show MST1 Proteins)/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.

  9. Mst1 (show MST1 Proteins) is required for Treg cells to mediate contact-dependent suppressor functions.

  10. Thioredoxin-1 (show TXN Proteins) functions as a molecular switch to turn off the oxidative stress-induced (show SQSTM1 Proteins) activation of MST1 (show MST1 Proteins).

STK4 Protein Profile

Protein Summary

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.

Gene names and symbols associated with STK4

  • serine/threonine kinase 4 (STK4)
  • serine/threonine kinase 4 (Stk4)
  • serine/threonine kinase 4 (stk4)
  • AI447339 protein
  • AU020804 protein
  • Kas-2 protein
  • krs2 protein
  • mst1 protein
  • TIIAC protein
  • ysk3 protein

Protein level used designations for STK4

MST-1 , STE20-like kinase MST1 , dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2)) , kinase responsive to stress 2 , mammalian STE20-like protein kinase 1 , mammalian sterile 20-like 1 , serine/threonine-protein kinase 4 , serine/threonine-protein kinase Krs-2 , Yeast Sps1/Ste20-related kinase 3 , sterile 20-like kinase 1

GENE ID SPECIES
6789 Homo sapiens
58231 Mus musculus
311622 Rattus norvegicus
514886 Bos taurus
419187 Gallus gallus
717730 Macaca mulatta
398925 Xenopus laevis
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