anti-serine/arginine-Rich Splicing Factor 2 (SRSF2) Antibodies

The protein encoded by SRSF2 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Additionally we are shipping SRSF2 Kits (14) and SRSF2 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SRSF2 6427 Q01130
SRSF2 20382 Q62093
SRSF2 494445 Q6PDU1
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Top anti-SRSF2 Antibodies at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of SFRS2 Antibody (Center) (ABIN650729) in mouse stomach tissue lysates (35 µg/lane). SFRS2 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-SFRS2 Antibody (N-term) (ABIN389301) in K562 cell line lysates (35 µg/lane).SFRS2(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with SFRS2 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of SFRS2 Antibody (Center) in mouse stomach tissue lysates (35ug/lane). SFRS2 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Amphibian Mouse Un-conjugated ELISA, EM, ICC, IF, IP, WB Immunocytochemistry/Immunofluorescence: SC35 Antibody (SC-35) [ABIN151301] - HS-68 cells were fixed and permeabilized with 4% Paraformaldehyde and 0.5% Triton X-100. Fixed cells were stained with Mouse Anti-Splicing Factor Clone: SC-35 diluted to 1:2,000. The antibody was developed using Goat Anti-Mouse IgG, FITC-conjugate. Western Blot: SC35 Antibody (SC-35) [ABIN151301] - SC-35 recombinant protein (3 ug) was separated on SDS-PAGE and probed with Mouse Anti-Splicing Factor SC-35 Clone: SC-35. The antibody was developed using Goat Anti-Mouse IgG-Peroxidase and a chemiluminescent substrate. Lanes 1. Antibody dilution 1:100; 2. Antibody dilution 1:250; 3. Antibody dilution 1:500; 4. Antibody dilution 1:1,000 0.1 mL Log in to see 7 to 9 Days
$381.94
Details
Human Mouse Un-conjugated IF, IP, WB Western blot analysis of SC35. Lysates from MG-63 human osteosarcoma cells were probed with anti-SC35 (clone alphaSC35, ABIN967516). SC35 is detected as a band of ~35 kDa. 0.1 mg Log in to see 6 to 8 Days
$177.30
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SFRS2 AntibodyTitration: 1.0 µg/mL  Positive Control: Hela Whole Cell  SRSF2 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 6 Days
$275.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry: SC35 Antibody [NBP2-47290] - Analysis of human Analysis of human skin tissue. Shows nuclear positivity. Immunocytochemistry/Immunofluorescence: SC35 Antibody [NBP2-47290] - Analysis of human cell line HEK 293 shows positivity in nucleus & cytoplasm. 0.1 mL Log in to see 14 to 17 Days
$439.69
Details
Chicken Rabbit Un-conjugated IHC (p), WB Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$676.50
Details

SRSF2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Top referenced anti-SRSF2 Antibodies

  1. Amphibian Monoclonal SRSF2 Primary Antibody for ELISA, EM - ABIN151301 : Nie, Hampton, Fu, Liu, Findlay, Salamonsen: A potential molecular mechanism for regulating pre-mRNA splicing of implantation-related genes through unique uterine expression of splicing factor SC35 in women and rhesus monkeys. in Reproduction (Cambridge, England) 2002 (PubMed)
    Show all 7 references for 151301

  2. Human Polyclonal SRSF2 Primary Antibody for EIA, IHC (p) - ABIN357967 : Merdzhanova, Edmond, De Seranno, Van den Broeck, Corcos, Brambilla, Brambilla, Gazzeri, Eymin: E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35. in Cell death and differentiation 2008 (PubMed)
    Show all 4 references for 357967

  3. Human Polyclonal SRSF2 Primary Antibody for EIA, WB - ABIN453825 : Solis, Peng, Crawford, Phillips, Patton: Growth hormone deficiency and splicing fidelity: two serine/arginine-rich proteins, ASF/SF2 and SC35, act antagonistically. in The Journal of biological chemistry 2008 (PubMed)
    Show all 4 references for 453825

  4. Human Monoclonal SRSF2 Primary Antibody for IF, IP - ABIN967516 : Fu: Specific commitment of different pre-mRNAs to splicing by single SR proteins. in Nature 1993 (PubMed)
    Show all 3 references for 967516

  5. Human Polyclonal SRSF2 Primary Antibody for IHC (p), WB - ABIN389301 : Sureau, Soret, Vellard, Crochet, Perbal: The PR264/c-myb connection: expression of a splicing factor modulated by a nuclear protooncogene. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Show all 2 references for 389301

  6. Human Polyclonal SRSF2 Primary Antibody for ICC, IF - ABIN4352137 : Guantes, Rastrojo, Neves, Lima, Aguado, Iborra: Global variability in gene expression and alternative splicing is modulated by mitochondrial content. in Genome research 2015 (PubMed)

More Antibodies against SRSF2 Interaction Partners

Human serine/arginine-Rich Splicing Factor 2 (SRSF2) interaction partners

  1. SRSF2 mutation is associated with chronic myelomonocytic leukemia.

  2. Mutation in SRSF2 gene is associated with Uveal Melanoma.

  3. Myelodysplastic syndrome -related P95 (show NBN Antibodies) point mutants of SRSF2 lead to alternative splicing of CDC25C (show CDC25C Antibodies) in a manner that is not dependent on the DNA damage response.

  4. Findings identify SRSF2 as a key regulator of RNA splicing dysregulation in cancer, with possible clinical implications as a candidate prognostic factor in patients with HCC (show FAM126A Antibodies).

  5. depletion of the splicing factor (show SLU7 Antibodies) arginine-rich splicing factor 2 (show SRSF1 Antibodies) (SRSF2) leads to enhanced cytotoxicity of breast cancer cells by KM100

  6. Data suggest that RBM25 (show RBM25 Antibodies) is required for the viability of multiple human cell lines, suggesting that it could play a key role in pre-mRNA splicing; a region of RBM25 (show RBM25 Antibodies) spanning Lys77 binds with high affinity to SRSF2, a crucial protein in exon definition, but only when Lys77 is unmethylated. (RBM25 (show RBM25 Antibodies) = RNA binding motif protein 25 (show RBM25 Antibodies); SRSF2 = serine- and arginine-rich splicing factor 2 (show SRSF1 Antibodies))

  7. mutations in the SRSF2/ASXL1 (show ASXL1 Antibodies)/RUNX1 (show RUNX1 Antibodies) gene panel identified as significant prognostic markers in systemic mastocytosis

  8. It was found that the absence of mutations in the SRSF2, ASXL1 (show ASXL1 Antibodies), and/or RUNX1gene panel at baseline and a reduction of the KIT D816V allele burden more than 25% at month 6 are the most favorable predictors for improved survival in midostaurin-treated advanced systemic mastocytosis patients.

  9. These findings provide insight into the functions of SRSF2 in HSV-1 replication and gene expression.

  10. SRSF2 mutations were identified in Chinese AML (show RUNX1 Antibodies) patients. Patients with SRSF2 mutations were older than those with wild-type. No differences in the sex, blood parameters, FAB (show FANCB Antibodies) subtypes, and karyotypes were seen between AML (show RUNX1 Antibodies) patients with and without SRSF2 mutations. SRSF2 mutation was not an independent prognostic factor in AML (show RUNX1 Antibodies) patients.

Mouse (Murine) serine/arginine-Rich Splicing Factor 2 (SRSF2) interaction partners

  1. Mice expressing Srsf2 mutation Srsf2P95H, which commonly occurs in individuals with MDS (show MECOM Antibodies) and AML (show RUNX1 Antibodies), in an inducible, hemizygous manner in hematopoietic cells rapidly succumbed to fatal bone marrow failure, demonstrating that Srsf2-mutated cells depend on the wild-type Srsf2 allele for survival.

  2. Findings have shown that SRSF2 not only is involved in splicing regulation of a large number of transcripts but also activates transcription of metabolism-related genes and transcription factors.

  3. Depletion of SRSF2 enhances reovirus replication and cytopathic effect, suggesting that T1L (show CERS6 Antibodies) mu2 (show AP2M1 Antibodies) modulation of splicing benefits the virus.

  4. HIV-1-Tat (show TAT Antibodies) Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A (show DYRK1A Antibodies) Kinase.

  5. The findings suggest that intact SRSF2 is essential for the functional integrity of the hematopoietic system and that its mutations likely contribute to development of myelodysplastic syndromes.

  6. SRSF2 mutations alter SRSF2's normal sequence-specific RNA binding activity, thereby altering the recognition of specific exonic splicing enhancer motifs to drive recurrent mis (show AMH Antibodies)-splicing of key hematopoietic regulators

  7. Study reports that SRSF2 (also known as SC35, an SR-splicing factor (show SLU7 Antibodies)) is part of the 7SK complex assembled at gene promoters and plays a direct role in transcription pause release.

  8. Specific effects on regulated splicing by SR proteins SRSF1 (show SRSF1 Antibodies) and SRSF2 depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.

  9. Deficiency of the splicing factor (show SLU7 Antibodies) Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn (show STMN1 Antibodies) splicing.

  10. Oct-4 distribution was examined relative to that of the unphosphorylated form of RNA polymerase II (Pol II) and splicing factor (SC 35) in the intranuclear entities such as perichromatin fibrils.

SRSF2 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11.

Gene names and symbols associated with SRSF2

  • serine/arginine-rich splicing factor 2 (SRSF2) antibody
  • serine/arginine-rich splicing factor 2 (Srsf2) antibody
  • serine/arginine-rich splicing factor 2 (srsf2) antibody
  • D11Wsu175e antibody
  • MRF-1 antibody
  • pr264 antibody
  • sc-35 antibody
  • sc35 antibody
  • sfrs2 antibody
  • sfrs2a antibody
  • Sfrs10 antibody
  • srp30b antibody

Protein level used designations for SRSF2

SR splicing factor 2 , splicing component, 35 kDa , splicing factor SC35 , splicing factor, arginine/serine-rich 2 , myelin regulatory factor 1 , putative myelin regulatory factor 1 , splicing factor Sc35 , splicing factor, arginine/serine-rich 2 (SC-35) , SC-35 , PR 264 protein , arginine/serine-rich2 splicing factor

GENE ID SPECIES
6427 Homo sapiens
20382 Mus musculus
494445 Rattus norvegicus
508312 Bos taurus
396195 Gallus gallus
768117 Sus scrofa
380435 Xenopus laevis
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