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The protein encoded by SRSF2 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Additionally we are shipping SRSF2 Kits (14) and SRSF2 Proteins (7) and many more products for this protein.
Showing 10 out of 34 products:
Amphibian Monoclonal SRSF2 Primary Antibody for ELISA, EM - ABIN151301
Nie, Hampton, Fu, Liu, Findlay, Salamonsen: A potential molecular mechanism for regulating pre-mRNA splicing of implantation-related genes through unique uterine expression of splicing factor SC35 in women and rhesus monkeys. in Reproduction (Cambridge, England) 2002
Show all 7 Pubmed References
Human Monoclonal SRSF2 Primary Antibody for IF, IP - ABIN967516
Fu: Specific commitment of different pre-mRNAs to splicing by single SR proteins. in Nature 1993
Show all 3 Pubmed References
Human Polyclonal SRSF2 Primary Antibody for ICC, IF - ABIN4352137
Guantes, Rastrojo, Neves, Lima, Aguado, Iborra: Global variability in gene expression and alternative splicing is modulated by mitochondrial content. in Genome research 2015
adverse prognostic impact of SRSF2 mutations on OS and AML (show RUNX1 Antibodies) transformation in patients with de novo MDS (show PAFAH1B1 Antibodies)
SRSF2 mutation is associated with chronic myelomonocytic leukemia.
Mutation in SRSF2 gene is associated with Uveal Melanoma.
Myelodysplastic syndrome -related P95 (show NBN Antibodies) point mutants of SRSF2 lead to alternative splicing of CDC25C (show CDC25C Antibodies) in a manner that is not dependent on the DNA damage response.
Findings identify SRSF2 as a key regulator of RNA splicing dysregulation in cancer, with possible clinical implications as a candidate prognostic factor in patients with HCC (show FAM126A Antibodies).
depletion of the splicing factor (show SLU7 Antibodies) arginine-rich splicing factor 2 (show SRSF1 Antibodies) (SRSF2) leads to enhanced cytotoxicity of breast cancer cells by KM100
Data suggest that RBM25 (show RBM25 Antibodies) is required for the viability of multiple human cell lines, suggesting that it could play a key role in pre-mRNA splicing; a region of RBM25 (show RBM25 Antibodies) spanning Lys77 binds with high affinity to SRSF2, a crucial protein in exon definition, but only when Lys77 is unmethylated. (RBM25 (show RBM25 Antibodies) = RNA binding motif protein 25 (show RBM25 Antibodies); SRSF2 = serine- and arginine-rich splicing factor 2 (show SRSF1 Antibodies))
mutations in the SRSF2/ASXL1 (show ASXL1 Antibodies)/RUNX1 (show RUNX1 Antibodies) gene panel identified as significant prognostic markers in systemic mastocytosis
It was found that the absence of mutations in the SRSF2, ASXL1 (show ASXL1 Antibodies), and/or RUNX1gene panel at baseline and a reduction of the KIT D816V allele burden more than 25% at month 6 are the most favorable predictors for improved survival in midostaurin-treated advanced systemic mastocytosis patients.
These findings provide insight into the functions of SRSF2 in HSV-1 replication and gene expression.
Mice expressing Srsf2 mutation Srsf2P95H, which commonly occurs in individuals with MDS (show MECOM Antibodies) and AML (show RUNX1 Antibodies), in an inducible, hemizygous manner in hematopoietic cells rapidly succumbed to fatal bone marrow failure, demonstrating that Srsf2-mutated cells depend on the wild-type Srsf2 allele for survival.
Findings have shown that SRSF2 not only is involved in splicing regulation of a large number of transcripts but also activates transcription of metabolism-related genes and transcription factors.
Depletion of SRSF2 enhances reovirus replication and cytopathic effect, suggesting that T1L (show CERS6 Antibodies) mu2 (show AP2M1 Antibodies) modulation of splicing benefits the virus.
HIV-1-Tat (show TAT Antibodies) Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A (show DYRK1A Antibodies) Kinase.
The findings suggest that intact SRSF2 is essential for the functional integrity of the hematopoietic system and that its mutations likely contribute to development of myelodysplastic syndromes.
SRSF2 mutations alter SRSF2's normal sequence-specific RNA binding activity, thereby altering the recognition of specific exonic splicing enhancer motifs to drive recurrent mis (show AMH Antibodies)-splicing of key hematopoietic regulators
Study reports that SRSF2 (also known as SC35, an SR-splicing factor (show SLU7 Antibodies)) is part of the 7SK complex assembled at gene promoters and plays a direct role in transcription pause release.
Specific effects on regulated splicing by SR proteins SRSF1 (show SRSF1 Antibodies) and SRSF2 depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.
Deficiency of the splicing factor (show SLU7 Antibodies) Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn (show STMN1 Antibodies) splicing.
Oct-4 distribution was examined relative to that of the unphosphorylated form of RNA polymerase II (Pol II) and splicing factor (SC 35) in the intranuclear entities such as perichromatin fibrils.
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11.
SR splicing factor 2
, splicing component, 35 kDa
, splicing factor SC35
, splicing factor, arginine/serine-rich 2
, myelin regulatory factor 1
, putative myelin regulatory factor 1
, splicing factor Sc35
, splicing factor, arginine/serine-rich 2 (SC-35)
, PR 264 protein
, arginine/serine-rich2 splicing factor