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serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 Proteins (SERPINA1)

The protein encoded by SERPINA1 is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Additionally we are shipping SERPINA1 Antibodies (372) and SERPINA1 Kits (54) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SERPINA1 20701 P22599
SERPINA1 5265 P01009
SERPINA1 24648 P17475
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Top SERPINA1 Proteins at antibodies-online.com

Showing 10 out of 51 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 50 μg Log in to see 11 Days
$308.00
Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293 Human His tag 10 μg Log in to see 2 to 3 Days
$262.50
Details
HOST_Mammalian Cells Human His tag 100 μg Log in to see 13 to 16 Days
$1,490.50
Details
HOST_Human Human Un-conjugated 1 mg Log in to see 2 to 3 Days
$110.25
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
Yeast Mesocricetus auratus His tag   1 mg Log in to see 56 to 66 Days
$3,072.67
Details
HOST_Human Human Un-conjugated   1 mg Log in to see 5 to 6 Days
$338.80
Details

SERPINA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , , , , , , ,
, , ,
Rat (Rattus) , ,

Top referenced SERPINA1 Proteins

  1. Human SERPINA1 Protein expressed in Human Cells - ABIN2002549 : Perlmutter, Daniels, Auerbach, De Schryver-Kecskemeti, Winter, Alpers: The alpha 1-antitrypsin gene is expressed in a human intestinal epithelial cell line. in The Journal of biological chemistry 1989 (PubMed)
    Show all 3 references for ABIN2002549

  2. Human SERPINA1 Protein expressed in HEK-293 Cells - ABIN2181744 : Niemann, Narkates, Miller: Isolation and serine protease inhibitory activity of the 44-residue, C-terminal fragment of alpha 1-antitrypsin from human placenta. in Matrix (Stuttgart, Germany) 1992 (PubMed)
    Show all 2 references for ABIN2181744

More Proteins for serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) Interaction Partners

Horse (Equine) serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) interaction partners

Chimpanzee serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) interaction partners

  1. The mechanism underlying the alpha(1)PI deficiency that attends HIV-1 infection, was investigated.

Mouse (Murine) serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) interaction partners

  1. Loss of alpha 1-Antitrypsin is associated with emphysema.

Human serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) interaction partners

  1. An increased NE: A1 AT ratio is closely associated with liver Inflammation in patients with NASH (show SAMSN1 Proteins) and could serve as a novel marker to predict NASH (show SAMSN1 Proteins) in humans

  2. Urinary CD59 (show CD59 Proteins) and alpha-1 antitrypsin are significantly altered in hypertensive patients developing albuminuria.

  3. low serum levels of AAT (show SERPINA1A Proteins) in patients with HSAP (show MSH6 Proteins) are correlated with disease severity and AAT (show SERPINA1A Proteins) may represent a potential target for therapies aiming to improve pancreatitis.

  4. findings show that alpha-1-antitrypsin induces the expression of hepcidin (show HAMP Proteins) in hepatocytes probably via inhibition of alpha-1-antitrypsin.

  5. In breast cancer patients, ER is constitutively activated, resulting in an E2-independent ER binding to the SERPINA1 gene and upregulation of SERPINA1 expression.

  6. Alpha-1 antitrypsin mitigates the inhibition of airway epithelial cell repair by neutrophil elastase (show ELANE Proteins).

  7. calprotectin and alpha1-antitrypsin dynamics in gastrointestinal GvHD

  8. FBG1 (show FBXO2 Proteins) degrades A1AT-Z through a Beclin1 (show BECN1 Proteins)-dependent arm of autophagy.

  9. Case Report: identify novel mutations of alpha-1 antitrypsin, with effects on folding, function, and polymerization.

  10. rs2896268 in SERPINA1 is associated with AAT (show SERPINA1A Proteins) level. rs671 in ALDH2 (show ALDH2 Proteins), rs1169288 in HNF1A (show HNF1A Proteins) and rs1260326 in GCKR (show GCKR Proteins), significantly associate with AAT (show SERPINA1A Proteins) levels.

Cow (Bovine) serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) interaction partners

  1. Comparisons of the expression patterns of cattle fetuses and their dams show that the PI gene is biallelically expressed in fetuses and predominantly monoallelically expressed in the dams.

SERPINA1 Protein Profile

Protein Summary

The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with SERPINA1

  • SH2B adaptor protein 2 (Sh2b2)
  • alpha-1-antitrypsin (SPI2)
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (serpina1)
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1)
  • alpha-1-antitrypsin (LOC100328621)
  • serine (or cysteine) preptidase inhibitor, clade A, member 1B (Serpina1b)
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (Serpina1)
  • A1A protein
  • A1AT protein
  • AAT protein
  • alpha-1-PI protein
  • alpha1AT protein
  • Aps protein
  • D12Ucla2 protein
  • Dom2 protein
  • MGC64429 protein
  • Pi protein
  • PI1 protein
  • PI2 protein
  • PRO2275 protein
  • SERPINA1 protein
  • serpina1d protein
  • Spi1 protein
  • Spi1-2 protein

Protein level used designations for SERPINA1

alpha-1-antiproteinase S , alpha-1-antitrypsin , alpha-1-proteinase inhibitor , alpha-1-antiproteinase 2 , alpha-1-antitrypsin 2 , alpha-1-proteinase inhibitor 2 , serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 , serine (or cysteine) proteinase inhibitor, clade A, member 1d , serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 , alpha-1 protease inhibitor , alpha-1-antiproteinase , serpin A1 , AAT , alpha-1 protease inhibitor 2 , alpha-1-antitrypsin 1-2 , serine (or cysteine) proteinase inhibitor, clade A, member 1b , serine protease inhibitor 1-2 , serine protease inhibitor A1b , serpin A1b , alpha-1-antitrypsin null , protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin , serine (or cysteine) proteinase inhibitor, clade A, member 1 , alpha-1-antitrypsin (protease inhibitor) , alpha-1-protease inhibitor , serine protease inhibitor alpha 1 , alpha 1 antitrypsin , protease inhibitor 1 (anti-elastase, antitrypsin, alpha-1) , serine (or cysteine) proteinase inhibitor, clade A (alpha-1antiproteinase, antitrypsin), member 1 , serine proteinase inhibitor, clade A, member 1 , alpha-1 antitrypsin , protease inhibitor 1 , Alpha-1 protease inhibitor

GENE ID SPECIES
100379265 Cavia porcellus
100065158 Equus caballus
379963 Xenopus laevis
423434 Gallus gallus
467541 Pan troglodytes
701361 Macaca mulatta
100145012 Xenopus (Silurana) tropicalis
100171544 Pongo abelii
100328621 Oryctolagus cuniculus
20701 Mus musculus
5265 Homo sapiens
24648 Rattus norvegicus
480422 Canis lupus familiaris
397688 Sus scrofa
280699 Bos taurus
443388 Ovis aries
101841330 Mesocricetus auratus
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