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serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 Proteins (SERPINA6)

SERPINA6 encodes an alpha-globulin protein with corticosteroid-binding properties. Additionally we are shipping SERPINA6 Antibodies (139) and SERPINA6 Kits (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SERPINA6 12401 Q06770
SERPINA6 866 P08185
SERPINA6 299270 P31211
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Top SERPINA6 Proteins at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$313.50
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$732.60
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$739.20
Details

SERPINA6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , , , , ,
,
Rat (Rattus) ,

Top referenced SERPINA6 Proteins

  1. Human SERPINA6 Protein expressed in Human Cells - ABIN2003707 : Séralini: [A new role for corticosteroid binding globulin (CBG), member of SERPIN superfamily]. in Comptes rendus des séances de la Société de biologie et de ses filiales 1992 (PubMed)
    Show all 2 references for ABIN2003707

  2. Mouse (Murine) SERPINA6 Protein expressed in Human Cells - ABIN2007647 : Seixas, Suriano, Carvalho, Seruca, Rocha, Di Rienzo: Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2. in Molecular biology and evolution 2007 (PubMed)
    Show all 2 references for ABIN2007647

More Proteins for serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6) Interaction Partners

Mouse (Murine) serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6) interaction partners

  1. CBG is involved in the gender differences observed in corticosteroids circulating levels and plays a role in the local regulation of corticosteroids availability in organs like lung.

  2. the same gene encodes brain and liver corticosteroid-binding globulin

  3. Data suggest fine control interaction between plasma CBG upregulation and stress-induced corticosterone (CORT (show CORT Proteins)) release in mouse model of psychological stress; CBG appears to function in maintaining dynamic equilibrium between CBG-bound/-unbound CORT (show CORT Proteins).

  4. Sequencing analysis showed that Cbg cDNA obtained from the mouse hypothalamus was homologous to Cbg cDNA obtained from the liver.

  5. Cbg-/- mice, unlike controls, remain insensitive to stress applied before memory retrieval. Furthermore, under stress conditions, we observed a blunted surge of corticosterone (CORT (show CORT Proteins)) in plasma and no free CORT (show CORT Proteins) rise in the hippocampus of Cbg-/-.

  6. study describes functional hyporesponsiveness and aldosterone resistance in distal colon of CBG(-/-) mice; steroid actions require an intrinsic but unknown function of CBG, which allows the sufficient supply of the hormone/s to the target tissue

  7. Critical role of plasma Cbg in providing an adequate endocrine and behavioral response to stress.

  8. These data suggest an active role for CBG in bioavailability, local delivery, and/or cellular signal transduction of glucocorticoids that extends beyond a function as a mere cargo transporter.

Human serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6) interaction partners

  1. Human cardiomyocytes express mineralocorticoid receptors, but are mostly free of nuclear glucocorticoid receptors. CBG is expressed in myocardium and in Purkinje fibers. CBG in heart is colocalized with mineralocorticoid receptor (show NR3C2 Proteins).

  2. SERPINA6-rs1998056 regulated by FOXA/ERalpha (show ESR1 Proteins) might be associated with female HCC (show FAM126A Proteins) risk

  3. genetic variation in the SERPINA6 gene may be associated with altered CBG levels during adolescence.

  4. the results suggest that DEX repression of Corticosteroid-binding globulin involves tethering of the glucocorticoid receptor (show NR3C1 Proteins) to C/EBPb (show CEBPB Proteins).

  5. 8 naturally occurring CBG mutants with abnormalities in cortisol-binding affinity, cortisol-binding capacity, production/secretion, sensitivity to proteolytic cleavage of the reactive center loop, or recognition by monoclonal antibodies used for ELISAs were identified

  6. The study investigate the half-life of intact and elastase cleaved CBG in the rabbit. The half-lives of intact and cleaved human CBG are 10 h and identical.

  7. CBG is coexpressed with hypothalamic neuropeptides.CBG may be involved in control of systemic and central stress response.

  8. Exome chip and 1000 Genomes imputation analysis of this locus in the CROATIA-Korcula cohort identified missense mutations in SERPINA6 and SERPINA1 (show SERPINA1 Proteins) that did not account for the effects of common variants

  9. Atomic interactions observed between progesterone and CBG explain the lower affinity of progesterone in comparison to corticosteroids.

  10. investigation of physicochemical, electronic, and structural requirements for selective and effective binding of steroids (many are endogenous steroid metabolites) to CBG and SHBG (show SHBG Proteins) active/ligand-binding sites

Pig (Porcine) serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6) interaction partners

  1. non-synonymous polymorphisms of SERPINA6, particularly SNPs c.919G>A and c.44G>T/c.622C>T, are associated with cortisol level, HPA (show HPSE Proteins) axis activity, and carcass and meat quality traits

  2. Cbg gene is a key regulator of cortisol levels and obesity susceptibility.

  3. Negative relationship exists between plasma cortisol and CBG under conditions of acute stress.

SERPINA6 Protein Profile

Protein Summary

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events.

Gene names and symbols associated with SERPINA6

  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (SERPINA6)
  • serpin (serpina6)
  • Corticosteroid-binding globulin-like (LOC100356417)
  • serine (or cysteine) peptidase inhibitor, clade A, member 6 (Serpina6)
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (Serpina6)
  • AI265318 protein
  • AV104445 protein
  • CBG protein
  • ep45-A protein
  • SERPINA6 protein

Protein level used designations for SERPINA6

CBG , corticosteroid-binding globulin , serpin A6 , transcortin , serine protease inhibitor A6 , estrogen-regulated protein EP45 , serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 , corticosteroid binding globulin , serine (or cysteine) proteinase inhibitor, clade A, member 6 , serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 , serine (or cysteine) peptidase inhibitor, clade A, member 6 , serpin peptidase inhibitor, clade A, member 6

GENE ID SPECIES
100172888 Pongo abelii
373636 Xenopus laevis
453131 Pan troglodytes
490838 Canis lupus familiaris
701121 Macaca mulatta
100356417 Oryctolagus cuniculus
12401 Mus musculus
866 Homo sapiens
299270 Rattus norvegicus
396736 Sus scrofa
101118224 Ovis aries
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