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serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7 Proteins (SERPINA7)

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. Additionally we are shipping serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7 Antibodies (114) and serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7 Kits (48) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SERPINA7 331535  
SERPINA7 6906 P05543
SERPINA7 81806 P35577
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Top serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7 Proteins at antibodies-online.com

Showing 10 out of 27 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$616.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$3,091.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,094.67
Details

SERPINA7 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , ,
,
Rat (Rattus) ,

More Proteins for serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7 (SERPINA7) Interaction Partners

Mouse (Murine) serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7 (SERPINA7) interaction partners

  1. the TBG promoter has a role in sustaining transgene expression in liver-specific pattern

Human serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7 (SERPINA7) interaction partners

  1. mutation in a liver-specific enhancer region of the TBG gene caused inherited TBG deficiency. To our knowledge, the present study is the first report of an inherited endocrine disorder caused by a mutation in an enhancer region.

  2. TBG allosteric regulation is entropy driven. The presence of multiple S states may allow more efficient T4 release due to protease activity.

  3. the TBG promoter has a role in sustaining transgene expression in liver-specific pattern

  4. Freshly isolated TBG-Chicago exists in loop expelled conformation. At 37C, the protein readily converts to a more stable loop inserted conformation with enhanced heat stability.

  5. an intragenic A/G polymorphism (125 bp upstream from exon 2) was identified. complete TBG deficiency was homozygous for the polymorphic TBG allele.

  6. Two novel variants in the thyroxine-binding globulin gene behind the diagnosis of TBG deficiency. homozygous. One involved codon 23 (TCA-->TAA) and the other, codon 223.

  7. Loop variants of the serpin thyroxine-binding globulin: implications for hormone release upon limited proteolysis.

  8. guanine deletion at position 1711, codon 201 (Asp (show ASIP Proteins)) in exon 2 (GAC (show GLS Proteins) --> AC) led to a frame shift and premature termination at codon 206, causing a short TBG protein of 205 amino acids (AA) compared to 395 AA of the normal TBG.

  9. new serpina7 gene variant in three members of the same family results in the replacement of the normal asparagine 233 by isoleucine and, subsequently, in disruption of a glycosylation site

  10. The first exon (exon 0) is a short noncoding sequence located 1.62 kilobase pairs (kbp (show KIAA1279 Proteins)) upstream from exon 1. HNF-1 (show HNF1A Proteins) site (located 65 bp upstream of the TSS (show RPL38 Proteins)) is required for the hepatocyte specific expression of the hTBG gene.

Pig (Porcine) serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7 (SERPINA7) interaction partners

  1. polymorphism in exon 2 in thyroxine-binding globulin is a candidate for the causative variation affecting testis size in boars.

serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7 (SERPINA7) Protein Profile

Protein Summary

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.

Gene names and symbols associated with SERPINA7

  • serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 (Serpina7)
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 (SERPINA7)
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 (Serpina7)
  • C730040N12Rik protein
  • TBG protein
  • THYROXINE-BINDING GLOBULIN protein

Protein level used designations for SERPINA7

T4-binding globulin , serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antipeptidase, antitrypsin), member 7 , serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 , serpin A7 , thyroxine-binding globulin , thyroxin-binding globulin , serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 , serine (or cysteine) proteinase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 7 , serine (or cysteine) proteinase inhibitor, clade A, member 7

GENE ID SPECIES
331535 Mus musculus
6906 Homo sapiens
81806 Rattus norvegicus
282518 Bos taurus
481007 Canis lupus familiaris
397125 Sus scrofa
443462 Ovis aries
465791 Pan troglodytes
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