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anti-serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 (SERPINB2) Antibodies

plays a role in proteolytic degradation of extracellular matrices in tissue remodeling; mediates the entire process of periodontal wound healing.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse SERPINB2 SERPINB2 18788 P12388
Anti-Human SERPINB2 SERPINB2 5055 P05120
Anti-Rat SERPINB2 SERPINB2 60325 P29524
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More Antibodies against serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 Interaction Partners

Cow (Bovine) serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 (SERPINB2) interaction partners

  1. The efficient and rapid formation of uPA:PAI-2 complexes was thus shown to be associated with specific and rapid internalisation of PAI-2, which could be localised within endosomes and lysosomes

Mouse (Murine) serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 (SERPINB2) interaction partners

  1. SerpinB2 plays an important role in proteostas

  2. PAI-2 is a novel regulator of venous thrombus resolution, which modulates several pathways involving both inflammatory and uPA (show PLAU Antibodies) activity mechanisms, distinct from PAI-1 (show SERPINE1 Antibodies)

  3. SerpinB2 has previously been implicated as a mediator of DMBA/TPA (show PLAT Antibodies)-induced skin carcinogenesis

  4. The presence of SerpinB2 on the surface of MPs provides a physiological mechanism whereby cancer cell SerpinB2 can reach the extracellular milieu and access urokinase plasminogen (show PLG Antibodies) activator (uPA (show PLAU Antibodies)).

  5. Brain metastatic cells from lung cancer and breast cancer express high levels of anti-plasminogen (show PLG Antibodies) activator (PA) serpins, including neuroserpin (show SERPINI1 Antibodies) and serpin B2, to prevent plasmin (show PLG Antibodies) generation and its metastasis-suppressive effects.

  6. C/EBP-beta (show CEBPB Antibodies) mediates both constitutive and LPS (show TLR4 Antibodies)-induced serpinB2 mRNA expression in mouse embryonic fibroblasts and inflammatory primary macrophages.

  7. Depletion PAI-2 resulted in NLRP3 (show NLRP3 Antibodies)- and ASC (show STS Antibodies)-dependent caspase-1 (show CASP1 Antibodies) activation and IL-1beta (show IL1B Antibodies) secretion in macrophages upon Toll-like receptor 2 (TLR2 (show TLR2 Antibodies)) and TLR4 (show TLR4 Antibodies) engagement.

  8. SerpinB2 can be induced by lentiviral infection in vivo.

  9. immune regulation of SerpinB2 expression plays a critical role in the development of Th2-mediated protective immunity against nematode infection by a mechanism involving CCL2 (show CCL2 Antibodies) production and macrophage infiltration.

  10. PAI-2 and TG2 (show TGM2 Antibodies) are downstream mediators in the antiapoptotic response triggered upon TBK1 (show TBK1 Antibodies) activation.

Human serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 (SERPINB2) interaction partners

  1. The variant of PAI-2 gene was associated with coronary artery disease and recurrent coronary event risk in Chinese Han population, in Xinjiang.

  2. SerpinB2 plays an important role in proteostas

  3. a total of 500 ESCC cases and 500 matched controls in a Southwest China population were evaluated for six SNPs in the exons of three Serpin genes (SerpinB5 (show SERPINB5 Antibodies), SerpinB2, and SerpinE1 (show SERPINE1 Antibodies)).

  4. PAI-2 was up-regulated in tensioned keloid fibroblasts and normal fibroblasts, but more so in keloid cells. Knockdown of PAI2 reduced cell proliferation in fibroblasts under tension.

  5. Soluble guanylate cyclase activators might alleviate or reverse vascular remodeling in pulmonary hypertension through the up-regulation of PAI-2.

  6. We found no association between allele frequency and risk of multiples sclerosis for any single nucleotide polymorphism investigated for serpinb2

  7. A role for SERPINB2 in patients with head and neck squamous cell carcinoma.

  8. Plasminogen activator inhibitor-2 polymorphism associates with recurrent coronary event risk in patients with high HDL (show HSD11B1 Antibodies) and C-reactive protein (show CRP Antibodies) levels.

  9. PSMB1 is part of the transcriptional machinery required for gastrin stimulated expression of PAI-2 and Reg1.

  10. SerpinB2 can be induced by lentiviral infection in vivo.

serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 (SERPINB2) Antigen Profile

Protein Summary

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1.

Gene names and symbols associated with SERPINB2

  • serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2) antibody
  • serine (or cysteine) peptidase inhibitor, clade B, member 2 (Serpinb2) antibody
  • serpin peptidase inhibitor, clade B (ovalbumin), member 2 (Serpinb2) antibody
  • HsT1201 antibody
  • ovalbumin antibody
  • PAI antibody
  • PAI-2 antibody
  • PAI2 antibody
  • Pai2a antibody
  • PLANH2 antibody
  • SERPINB2 antibody

Protein level used designations for SERPINB2

plasminogen activator inhibitor, type 2 (arginine-serpin) , serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 , serpin peptidase inhibitor, clade B (ovalbumin), member 2 , plasminogen activator inhibitor 2, macrophage , plasminogen activator inhibitor, type II , serine (or cysteine) proteinase inhibitor, clade B, member 2 , serpin B2 , monocyte Arg-serpin , placental plasminogen activator inhibitor , plasminogen activator inhibitor 2 , plasminogen activator inhibitor, type II (arginine-serpin) , urokinase inhibitor , serine proteinase inhibitor, clade B, member 2 , PAI-2 , plasminogen activator inhibitor 2 type A , serine (or cysteine) peptidase inhibitor, clade B, member 2 , plasminogen activator inhibitor-2 , serine/cysteine proteinase inhibitor, clade B (ovalbumin), member 2 , plasminogen activator inhibitor type 2

GENE ID SPECIES
281376 Bos taurus
739078 Pan troglodytes
100051584 Equus caballus
18788 Mus musculus
5055 Homo sapiens
609604 Canis lupus familiaris
100216509 Oryctolagus cuniculus
60325 Rattus norvegicus
100722462 Cavia porcellus
100519286 Sus scrofa
505184 Bos taurus
420896 Gallus gallus
100381268 Ovis aries
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