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serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 Proteins (SERPINB2)

Inhibits urokinase-type plasminogen activator.

list all proteins Gene Name GeneID UniProt
Mouse SERPINB2 SERPINB2 18788 P12388
Human SERPINB2 SERPINB2 5055 P05120
Rat SERPINB2 SERPINB2 60325 P29524
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More Proteins for serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 (SERPINB2) Interaction Partners

Cow (Bovine) serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 (SERPINB2) interaction partners

  1. The efficient and rapid formation of uPA:PAI-2 complexes was thus shown to be associated with specific and rapid internalisation of PAI-2, which could be localised within endosomes and lysosomes

Mouse (Murine) serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 (SERPINB2) interaction partners

  1. SerpinB2 plays an important role in proteostas

  2. PAI-2 is a novel regulator of venous thrombus resolution, which modulates several pathways involving both inflammatory and uPA (show PLAU Proteins) activity mechanisms, distinct from PAI-1 (show SERPINE1 Proteins)

  3. SerpinB2 has previously been implicated as a mediator of DMBA/TPA (show PLAT Proteins)-induced skin carcinogenesis

  4. The presence of SerpinB2 on the surface of MPs provides a physiological mechanism whereby cancer cell SerpinB2 can reach the extracellular milieu and access urokinase plasminogen (show PLG Proteins) activator (uPA (show PLAU Proteins)).

  5. Brain metastatic cells from lung cancer and breast cancer express high levels of anti-plasminogen (show PLG Proteins) activator (PA) serpins, including neuroserpin (show SERPINI1 Proteins) and serpin B2, to prevent plasmin (show PLG Proteins) generation and its metastasis-suppressive effects.

  6. C/EBP-beta (show CEBPB Proteins) mediates both constitutive and LPS (show TLR4 Proteins)-induced serpinB2 mRNA expression in mouse embryonic fibroblasts and inflammatory primary macrophages.

  7. Depletion PAI-2 resulted in NLRP3- and ASC-dependent caspase-1 activation and IL-1beta secretion in macrophages upon Toll-like receptor 2 (TLR2) and TLR4 engagement.

  8. SerpinB2 can be induced by lentiviral infection in vivo.

  9. immune regulation of SerpinB2 expression plays a critical role in the development of Th2-mediated protective immunity against nematode infection by a mechanism involving CCL2 (show CCL2 Proteins) production and macrophage infiltration.

  10. PAI-2 and TG2 (show TGM2 Proteins) are downstream mediators in the antiapoptotic response triggered upon TBK1 (show TBK1 Proteins) activation.

Human serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 (SERPINB2) interaction partners

  1. The variant of PAI-2 gene was associated with coronary artery disease and recurrent coronary event risk in Chinese Han population, in Xinjiang.

  2. SerpinB2 plays an important role in proteostas

  3. a total of 500 ESCC cases and 500 matched controls in a Southwest China population were evaluated for six SNPs in the exons of three Serpin genes (SerpinB5 (show SERPINB5 Proteins), SerpinB2, and SerpinE1 (show SERPINE1 Proteins)).

  4. PAI-2 was up-regulated in tensioned keloid fibroblasts and normal fibroblasts, but more so in keloid cells. Knockdown of PAI2 reduced cell proliferation in fibroblasts under tension.

  5. Soluble guanylate cyclase activators might alleviate or reverse vascular remodeling in pulmonary hypertension through the up-regulation of PAI-2.

  6. We found no association between allele frequency and risk of multiples sclerosis for any single nucleotide polymorphism investigated for serpinb2

  7. A role for SERPINB2 in patients with head and neck squamous cell carcinoma.

  8. Plasminogen activator inhibitor-2 polymorphism associates with recurrent coronary event risk in patients with high HDL (show HSD11B1 Proteins) and C-reactive protein (show CRP Proteins) levels.

  9. PSMB1 is part of the transcriptional machinery required for gastrin stimulated expression of PAI-2 and Reg1.

  10. SerpinB2 can be induced by lentiviral infection in vivo.

serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 (SERPINB2) Protein Profile

Protein Summary

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1.

Gene names and symbols associated with SERPINB2

  • serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2)
  • serine (or cysteine) peptidase inhibitor, clade B, member 2 (Serpinb2)
  • serpin peptidase inhibitor, clade B (ovalbumin), member 2 (Serpinb2)
  • HsT1201 protein
  • ovalbumin protein
  • PAI protein
  • PAI-2 protein
  • PAI2 protein
  • Pai2a protein
  • PLANH2 protein
  • SERPINB2 protein

Protein level used designations for SERPINB2

plasminogen activator inhibitor, type 2 (arginine-serpin) , serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 , serpin peptidase inhibitor, clade B (ovalbumin), member 2 , plasminogen activator inhibitor 2, macrophage , plasminogen activator inhibitor, type II , serine (or cysteine) proteinase inhibitor, clade B, member 2 , serpin B2 , monocyte Arg-serpin , placental plasminogen activator inhibitor , plasminogen activator inhibitor 2 , plasminogen activator inhibitor, type II (arginine-serpin) , urokinase inhibitor , serine proteinase inhibitor, clade B, member 2 , PAI-2 , plasminogen activator inhibitor 2 type A , serine (or cysteine) peptidase inhibitor, clade B, member 2 , plasminogen activator inhibitor-2 , serine/cysteine proteinase inhibitor, clade B (ovalbumin), member 2 , plasminogen activator inhibitor type 2

GENE ID SPECIES
281376 Bos taurus
739078 Pan troglodytes
100051584 Equus caballus
18788 Mus musculus
5055 Homo sapiens
609604 Canis lupus familiaris
100216509 Oryctolagus cuniculus
60325 Rattus norvegicus
100722462 Cavia porcellus
100519286 Sus scrofa
505184 Bos taurus
420896 Gallus gallus
100381268 Ovis aries
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