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serine protease inhibitor possibly involved in modulating extracellular matrix deposition. Additionally we are shipping and and many more products for this protein.
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Human Polyclonal SERPINB7 Primary Antibody for EIA, WB - ABIN453823
Wang, Chen, Pan, Ren, Wang, Zhang, Hao, Zhu, Lu, Han: [Association of single nucleotide polymorphism of megsin gene with IgA nephropathy]. in Zhonghua yi xue za zhi 2006
Show all 3 references for ABIN453823
Suggest that the down-regulation of megsin might exert beneficial effects on the diabetic kidney partly through down-regulation of p27(kip1 (show CDKN1B Antibodies)).
diabetic nephropathy model in triple transgenic mice overexpressing RAGE (show AGER Antibodies), iNOS (show NOS2 Antibodies) & megsin; triple-hit damage develops severe diabetic nephropathy at early age with mesangial expansion, nodule-like lesion & tubulointerstitial damage with oxidative stress
Results show splice variants from the two recurrent splice-site mutations in SERPINB7, provide evidence for the pathogenicity of the mutations and suggest an in-frame deletion of exon 3 may cause NPPK and that the CD-loop could affect SERPINB7 function
These results indicate that megsin gene variants may play a role in the severity, development, and/or progression of IgAN in Northwest Chinese population
Recessive missense mutation of SERPINB7 gene was found in Japanese families diagnosed with palmoplantar keratosis.
Megsin 2093C/T TT genotype, and C25663G G allele and GG genotype were associated with the risk of IgAN in Asian population
These data clearly provide further evidence that NPPK is caused by loss-of-function mutations in SERPINB7.
megsin 2093C/T C allele may be genetic marker for IgA nephropathy susceptibility [review]
The mean concentration of serpin B7 at 28-32 weeks was 1.5-fold higher in women with subsequent preterm deliveries compared to controls.
study reports on seven unrelated Chinese patients with Nagashima-Type Palmoplantar Keratosis with four underlying SERPINB7 mutations, of which one is a recurrent variant (c.796C>T)
All of the identified mutants are predicted to cause premature termination upstream of the reactive site, which inhibits the proteases, suggesting a complete loss of the protease inhibitory activity of SERPINB7 in palmoplantar keratosis skin.
A267G in 5'-untranslated region within the exon of megsin may be one of the substantial genetic basis for differentiating "deficiency of liver yin and kidney yin" syndrome and "deficiency of qi and yin" syndrome in primary immunoglobulin A nephropathy.
serine protease inhibitor possibly involved in modulating extracellular matrix deposition
serpin peptidase inhibitor, clade B (ovalbumin), member 7
, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7
, megsin (predicted)-like
, serpin B7
, serpin peptidase inhibitor, clade B, member 7, isoform 1
, serine (or cysteine) proteinase inhibitor, clade B, member 7
, mesangium predominant gene, megsin
, serine (or cysteine) peptidase inhibitor, clade B, member 7