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serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 Proteins (SERPINB9)

SERPINB9 encodes a member of the serine protease inhibitor family which are also known as serpins. Additionally we are shipping SERPINB9 Antibodies (95) and SERPINB9 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SERPINB9 SERPINB9 361241  
Mouse SERPINB9 SERPINB9 20723  
SERPINB9 5272 P50453
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Top SERPINB9 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human His tag   10 μg Log in to see 5 Days
$143.00
Details

SERPINB9 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,

More Proteins for serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9) Interaction Partners

Pig (Porcine) serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9) interaction partners

Mouse (Murine) serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9) interaction partners

  1. Data suggest that reactive oxygen species (ROS) generated within cytotoxic lymphocytes by receptor stimulation are required for lysosomal permeabilization and release of GzmB (granzyme B) into the cytosol and for inactivation of serpin B9.

  2. the negative regulation of DC priming of CD8 (show CD8A Proteins) T lymphocyte immunity by CTL killing is mitigated by the physiological inhibition of GrB by Spi6.

  3. SPI-CI (show OVA Proteins) is a novel immune escape molecule that acts in concert with SPI (show CHGA Proteins)-6 to prevent cytotoxic lymphocyte-mediated killing of tumor cells.

  4. Estrogen induction of PI-9 may reduce the ability of cytolytic lymphocytes-mediated immune surveillance to destroy newly transformed cells

  5. In mCAP3 (show ST14 Proteins), an intact catalytic triad was necessary for activation of ENaC (show SCNN1A Proteins) but not for intramolecular cleavage of the protease.

  6. protects hepatocytes against excessively vigorous granzyme B-dependent killing but may also delay immune clearance of virally infected hepatocytes

  7. deficiency in a weak intracellular inhibitor of neutrophil elastase (show ELANE Proteins) results in an acute inflammatory response that protects from P. aeruginosa but does not cause lung disease

  8. SPI-6 is selectively up-regulated in hepatocytes in response to infiltration of the liver by NK cells that express perforin and enzymatically active granzyme B.

  9. Increased SPI (show CHGA Proteins)-6 expression is not sufficient to confer lipopolysaccharide-treated dendritic cells with resistance to direct killing in vivo.

Human serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9) interaction partners

  1. Data show that oropharyngeal squamous cell carcinomas (OPSCCs) express granzyme inhibitors SERPINB1 (show SERPINB1 Proteins), SERPINB4 (show SERPINB4 Proteins) and SERPINB9 for cytotoxicity and the expression was not different between human papillomavirus (HPV)-positive and HPV-negative tumors.

  2. Pediatric CNS-PNETs evade immune recognition by downregulating cell surface MHC (show HLAE Proteins)-I and CD1d (show CD1D Proteins) expression. Intriguingly, expression of SERPINB9, SERPINB1 (show SERPINB1 Proteins), and SERPINB4 (show SERPINB4 Proteins) is acquired during tumorigenesis in 29%, 29%, and 57% of the tumors

  3. Data suggest that reactive oxygen species (ROS) generated within cytotoxic lymphocytes by receptor stimulation are required for lysosomal permeabilization and release of GzmB (granzyme B) into the cytosol and for inactivation of serpin B9.

  4. Increased intracellular PI-9 activity in mononuclear phagocytes from HIV-infected patients contributes to successful intracellular infection by virulent Mycobacterium tuberculosis.

  5. Suppression of granzyme B initiated apoptosis in protease inhibitor-9-expressing leukemia cells.

  6. SerpinB9 expression in human renal tubular epithelial cells is induced by triggering of the viral dsRNA sensors TLR3 (show TLR3 Proteins), MDA5 (show IFIH1 Proteins) and RIG-I (show DDX58 Proteins) during subclinical rejection.

  7. lung cancer cells utilise their increased PI-9 expression to protect from granzyme B-mediated cytotoxicity as an immune evasion mechanism

  8. Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis.

  9. PI-9 induction within human mononuclear phagocytes by virulent Mycobacterium tuberculosis serves to protect these primary targets of infection from elimination by apoptosis and thereby promotes intracellular survival of the organism.

  10. constitutive expression of serine protease inhibitor 9 (PI-9) on human peripheral blood-and bone marrow-derived mesenchymal stem cells is a major defense mechanism against granzyme B-mediated destruction by NK cells

SERPINB9 Protein Profile

Protein Summary

This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6.

Gene names and symbols associated with SERPINB9

  • serpin peptidase inhibitor, clade B (ovalbumin), member 9 (Serpinb9)
  • serpin peptidase inhibitor, clade B (ovalbumin), member 9 (SERPINB9)
  • serine (or cysteine) peptidase inhibitor, clade B, member 9 (Serpinb9)
  • BB283241 protein
  • CAP-3 protein
  • CAP3 protein
  • ovalbumin protein
  • PI-9 protein
  • PI9 protein
  • SERPINB9 protein
  • Spi6 protein

Protein level used designations for SERPINB9

serine (or cysteine) peptidase inhibitor, clade B, member 9 , serpin B9 , serpin peptidase inhibitor, clade B (ovalbumin), member 9 , serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9 , Cytoplasmic antiproteinase 3 , serpin B9-like , serine (or cysteine) proteinase inhibitor, clade B, member 9 , serine protease inhibitor 6 , cytoplasmic antiproteinase 3 , peptidase inhibitor 9 , protease inhibitor 9 (ovalbumin type) , serpin peptidase inhibitor, clade B, member 9

GENE ID SPECIES
361241 Rattus norvegicus
488192 Canis lupus familiaris
524513 Bos taurus
707580 Macaca mulatta
744242 Pan troglodytes
100126851 Sus scrofa
100388662 Callithrix jacchus
100445070 Pongo abelii
100596895 Nomascus leucogenys
20723 Mus musculus
5272 Homo sapiens
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