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serine protease inhibitor possibly involved in modulating extracellular matrix deposition. Additionally we are shipping and and many more products for this protein.
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Human Polyclonal SERPINB7 Primary Antibody for EIA, WB - ABIN453823
Wang, Chen, Pan, Ren, Wang, Zhang, Hao, Zhu, Lu, Han: [Association of single nucleotide polymorphism of megsin gene with IgA nephropathy]. in Zhonghua yi xue za zhi 2006
Show all 3 references for ABIN453823
Human Polyclonal SERPINB7 Primary Antibody for ICC, IF - ABIN4352995
Kubo, Shiohama, Sasaki, Nakabayashi, Kawasaki, Atsugi, Sato, Shimizu, Mikami, Tanizaki, Uchiyama, Maeda, Ito, Sakabe, Heike, Okuyama, Kosaki, Kosaki, Kudoh, Hata, Umezawa, Tokura, Ishiko, Niizeki et al.: Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis. ... in American journal of human genetics 2013
Suggest that the down-regulation of megsin might exert beneficial effects on the diabetic kidney partly through down-regulation of p27(kip1 (show CDKN1B Antibodies)).
diabetic nephropathy model in triple transgenic mice overexpressing RAGE (show AGER Antibodies), iNOS (show NOS2 Antibodies) & megsin; triple-hit damage develops severe diabetic nephropathy at early age with mesangial expansion, nodule-like lesion & tubulointerstitial damage with oxidative stress
Direct sequencing of SERPINB7 revealed five homozygous founder mutations (c.796C>T) and four compound heterozygous mutations in nine patients, including one novel mutation (c.122_127delTGGTCC).
Case Report: striate palmoplantar keratoderma showing transgrediens in a patient with heterozygote nonsense mutations in DSG1 (show DSG1 Antibodies) and SERPINB7.
Results show splice variants from the two recurrent splice-site mutations in SERPINB7, provide evidence for the pathogenicity of the mutations and suggest an in-frame deletion of exon 3 may cause NPPK and that the CD-loop could affect SERPINB7 function
These results indicate that megsin gene variants may play a role in the severity, development, and/or progression of IgAN in Northwest Chinese population
Recessive missense mutation of SERPINB7 gene was found in Japanese families diagnosed with palmoplantar keratosis.
Megsin 2093C/T TT genotype, and C25663G G allele and GG genotype were associated with the risk of IgAN in Asian population
These data clearly provide further evidence that NPPK is caused by loss-of-function mutations in SERPINB7.
megsin 2093C/T C allele may be genetic marker for IgA nephropathy susceptibility [review]
The mean concentration of serpin B7 at 28-32 weeks was 1.5-fold higher in women with subsequent preterm deliveries compared to controls.
study reports on seven unrelated Chinese patients with Nagashima-Type Palmoplantar Keratosis with four underlying SERPINB7 mutations, of which one is a recurrent variant (c.796C>T)
serine protease inhibitor possibly involved in modulating extracellular matrix deposition
serpin peptidase inhibitor, clade B (ovalbumin), member 7
, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7
, megsin (predicted)-like
, serpin B7
, serpin peptidase inhibitor, clade B, member 7, isoform 1
, serine (or cysteine) proteinase inhibitor, clade B, member 7
, mesangium predominant gene, megsin
, serine (or cysteine) peptidase inhibitor, clade B, member 7