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anti-serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) Antibodies

The product encoded by SERPIND1 is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. Additionally we are shipping serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Kits (45) and serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Proteins (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SERPIND1 15160 P49182
SERPIND1 3053 P05546
SERPIND1 79224 Q64268
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Top anti-serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Antibodies at antibodies-online.com

Showing 10 out of 65 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SERPIND1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using Heparin Cofactor II Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using Heparin Cofactor II Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 16 Days
$163.90
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated ELISA   100 μg Log in to see 16 Days
$218.90
Details
Human Rabbit Un-conjugated IF, IHC (p), ELISA 100 μL Log in to see 8 to 10 Days
$478.50
Details
Mouse Rabbit Un-conjugated ELISA   100 μg Log in to see 16 Days
$273.90
Details
Mouse Rabbit Un-conjugated ELISA   100 μg Log in to see 16 Days
$163.90
Details
Human Mouse Un-conjugated IHC (p) Immunochemical staining of human serpinD1 in human hepatoma with mouse monoclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte. Immunochemical staining of human serpinD1 in human liver with mouse monoclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte. 100 μg Log in to see 16 Days
$218.90
Details
Human Rabbit Un-conjugated IP, ELISA, WB 100 μg Log in to see 16 Days
$218.90
Details

SERPIND1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,

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Top referenced anti-serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Antibodies

  1. Human Polyclonal SERPIND1 Primary Antibody for IF, IHC - ABIN1533588 : Blinder, Marasa, Reynolds, Deaven, Tollefsen: Heparin cofactor II: cDNA sequence, chromosome localization, restriction fragment length polymorphism, and expression in Escherichia coli. in Biochemistry 1988 (PubMed)
    Show all 2 references for ABIN1533588

  2. Mouse (Murine) Monoclonal SERPIND1 Primary Antibody for ELISA - ABIN2000387 : Rau, Deans, Hoffman, Thomas, Malcom, Zieske, Strong, Koch, Church: Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. in Experimental and molecular pathology 2009 (PubMed)

  3. Human Polyclonal SERPIND1 Primary Antibody for WB - ABIN2776770 : Rahgozar, Giannakopoulos, Yan, Wei, Cheng Qi, Gemmell, Krilis: Beta2-glycoprotein I protects thrombin from inhibition by heparin cofactor II: potentiation of this effect in the presence of anti-beta2-glycoprotein I autoantibodies. in Arthritis and rheumatism 2008 (PubMed)

More Antibodies against serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Interaction Partners

Mouse (Murine) serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) interaction partners

  1. In this study, we demonstrate a previously unknown role for HCII in host defense

  2. HCII potentiates the activation of vascular endothelial cells and the promotion of angiogenesis in response to hindlimb ischemia via an AMPK (show PRKAA1 Antibodies)-eNOS (show NOS3 Antibodies) signaling pathway.

  3. HCII mediates the antithrombotic effect of porcine skin dermatan sulfate after injury to the carotid arterial endothelium in mice.

  4. In HCII(+/-) mice, prominent intimal hyperplasia with increased cellular proliferation was observed after tube cuff (show CUFF Antibodies) and wire vascular injury.

  5. HCII deficiency promotes atherogenesis and neointima formation

  6. The reactions with thrombin (show F2 Antibodies) or APC (show APC Antibodies) of recombinant alpha(1)-PI (show SERPINA1 Antibodies) M358R variants with or without the HCII extension were characterized electrophoretically and kinetically

  7. These results support the hypothesis that HCII interacts with dermatan sulfate in the vessel wall after disruption of the endothelium and that this interaction regulates thrombus formation in vivo.

Human serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) interaction partners

  1. Molecular modelling of HCII 1-75 predicted those portions of the acidic extension that had been previously visualized in crystal structures, and suggested that an alpha-helix found between residues 26 and 36 stabilizes one found between residues 61-67.

  2. In this study, we demonstrate a previously unknown role for HCII in host defense.

  3. HCII potentiates the activation of vascular endothelial cells and the promotion of angiogenesis in response to hindlimb ischemia via an AMPK (show PRKAA1 Antibodies)-eNOS (show NOS3 Antibodies) signaling pathway.

  4. Plasma heparin cofactor II activity was independently and inversely associated with the development of cardiac remodeling, including cardiac concentric change, left atrial enlargement and left ventricular diastolic dysfunction.

  5. [REVIEW]HCII protects against vascular remodeling, including atherosclerosis

  6. potential for oversulfated disaccharides in controlling HCII-regulated thrombin (show F2 Antibodies) generation

  7. Aspartic acid residues 72 and 75 and tyrosine-sulfate 73 of heparin cofactor II promote

  8. role of basic amino acids of the A helix of heparin cofactor II in heparin- or dermatan sulfate-mediated thrombin (show F2 Antibodies) inhibition.

  9. Altering heparin cofactor II at VAL439 (P6) either impairs inhibition of thrombin (show F2 Antibodies) or confers elastase resistance.

  10. The interactions of HCII with various heparins in solution competition experiments using SPR (show SPR Antibodies) show that while calcium enhances this interaction, the activity of heparin-HCII complex against thrombin (show F2 Antibodies) is not calcium dependent but can be enhanced by it.

serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) Antigen Profile

Protein Summary

The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency.

Gene names and symbols associated with SERPIND1

  • serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 (serpind1) antibody
  • serpin peptidase inhibitor, clade D (heparin cofactor), member 1 (SERPIND1) antibody
  • heparin cofactor II (LOC100155945) antibody
  • serine (or cysteine) peptidase inhibitor, clade D, member 1 (Serpind1) antibody
  • serpin peptidase inhibitor, clade D (heparin cofactor), member 1 (Serpind1) antibody
  • AA985900 antibody
  • AI303446 antibody
  • D22S673 antibody
  • HC2 antibody
  • HCF2 antibody
  • HCII antibody
  • HLS2 antibody
  • LS2 antibody
  • rls2var1 antibody
  • THPH10 antibody

Protein level used designations for SERPIND1

heparin cofactor 2 , serpin peptidase inhibitor, clade D (heparin cofactor), member 1 , heparin cofactor 2-like , HC-II , heparin cofactor II , protease inhibitor leuserpin-2 , serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 , serpin D1 , leuserpin 2 , leuserpin-2 , serine (or cysteine) peptidase inhibitor, clade D, member 1 , serine (or cysteine) proteinase inhibitor, clade D, member 1 , serpin peptidase inhibitor, clade D, member 1

GENE ID SPECIES
359841 Danio rerio
696950 Macaca mulatta
100467362 Ailuropoda melanoleuca
100542650 Meleagris gallopavo
100596966 Nomascus leucogenys
100629879 Equus caballus
100155945 Sus scrofa
15160 Mus musculus
3053 Homo sapiens
100682658 Canis lupus familiaris
79224 Rattus norvegicus
100009170 Oryctolagus cuniculus
100125764 Bos taurus
395877 Gallus gallus
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