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serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Proteins (SERPIND1)

The product encoded by SERPIND1 is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. Additionally we are shipping serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Antibodies (63) and serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Kits (45) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SERPIND1 15160 P49182
SERPIND1 3053 P05546
SERPIND1 79224 Q64268
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Top serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
$319.00
Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$206.80
Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293 Human His tag 10 μg Log in to see 2 to 3 Days
$241.50
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$820.60
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Human His tag   0.05 mg Log in to see 2 to 3 Days
$584.38
Details

SERPIND1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,

Human , , , , ,
, ,
Rat (Rattus)

Top referenced serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Proteins

  1. Human SERPIND1 Protein expressed in Human Cells - ABIN2002527 : Zhang, Mehringer, Van Deerlin, Kozak, Tollefsen: Murine heparin cofactor II: purification, cDNA sequence, expression, and gene structure. in Biochemistry 1994 (PubMed)
    Show all 4 references for ABIN2002527

  2. Mouse (Murine) SERPIND1 Protein expressed in Human Cells - ABIN2007355 : Giri, Tollefsen: Placental dermatan sulfate: isolation, anticoagulant activity, and association with heparin cofactor II. in Blood 2006 (PubMed)
    Show all 4 references for ABIN2007355

  3. Human SERPIND1 Protein expressed in HEK-293 Cells - ABIN2181748 : Van Deerlin, Tollefsen: The N-terminal acidic domain of heparin cofactor II mediates the inhibition of alpha-thrombin in the presence of glycosaminoglycans. in The Journal of biological chemistry 1991 (PubMed)

More Proteins for serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) Interaction Partners

Mouse (Murine) serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) interaction partners

  1. In this study, we demonstrate a previously unknown role for HCII in host defense

  2. HCII potentiates the activation of vascular endothelial cells and the promotion of angiogenesis in response to hindlimb ischemia via an AMPK (show PRKAA1 Proteins)-eNOS (show NOS3 Proteins) signaling pathway.

  3. HCII mediates the antithrombotic effect of porcine skin dermatan sulfate after injury to the carotid arterial endothelium in mice.

  4. In HCII(+/-) mice, prominent intimal hyperplasia with increased cellular proliferation was observed after tube cuff and wire vascular injury.

  5. HCII deficiency promotes atherogenesis and neointima formation

  6. The reactions with thrombin (show F2 Proteins) or APC (show APC Proteins) of recombinant alpha(1)-PI (show SERPINA1 Proteins) M358R variants with or without the HCII extension were characterized electrophoretically and kinetically

  7. These results support the hypothesis that HCII interacts with dermatan sulfate in the vessel wall after disruption of the endothelium and that this interaction regulates thrombus formation in vivo.

Human serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) interaction partners

  1. Molecular modelling of HCII 1-75 predicted those portions of the acidic extension that had been previously visualized in crystal structures, and suggested that an alpha-helix found between residues 26 and 36 stabilizes one found between residues 61-67.

  2. In this study, we demonstrate a previously unknown role for HCII in host defense.

  3. HCII potentiates the activation of vascular endothelial cells and the promotion of angiogenesis in response to hindlimb ischemia via an AMPK (show PRKAA1 Proteins)-eNOS (show NOS3 Proteins) signaling pathway.

  4. Plasma heparin cofactor II activity was independently and inversely associated with the development of cardiac remodeling, including cardiac concentric change, left atrial enlargement and left ventricular diastolic dysfunction.

  5. [REVIEW]HCII protects against vascular remodeling, including atherosclerosis

  6. potential for oversulfated disaccharides in controlling HCII-regulated thrombin (show F2 Proteins) generation

  7. Aspartic acid residues 72 and 75 and tyrosine-sulfate 73 of heparin cofactor II promote

  8. role of basic amino acids of the A helix of heparin cofactor II in heparin- or dermatan sulfate-mediated thrombin (show F2 Proteins) inhibition.

  9. Altering heparin cofactor II at VAL439 (P6) either impairs inhibition of thrombin (show F2 Proteins) or confers elastase resistance.

  10. The interactions of HCII with various heparins in solution competition experiments using SPR (show SPR Proteins) show that while calcium enhances this interaction, the activity of heparin-HCII complex against thrombin (show F2 Proteins) is not calcium dependent but can be enhanced by it.

serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) Protein Profile

Protein Summary

The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency.

Gene names and symbols associated with SERPIND1

  • serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 (serpind1)
  • serpin peptidase inhibitor, clade D (heparin cofactor), member 1 (SERPIND1)
  • heparin cofactor II (LOC100155945)
  • serine (or cysteine) peptidase inhibitor, clade D, member 1 (Serpind1)
  • serpin peptidase inhibitor, clade D (heparin cofactor), member 1 (Serpind1)
  • AA985900 protein
  • AI303446 protein
  • D22S673 protein
  • HC2 protein
  • HCF2 protein
  • HCII protein
  • HLS2 protein
  • LS2 protein
  • rls2var1 protein
  • THPH10 protein

Protein level used designations for SERPIND1

heparin cofactor 2 , serpin peptidase inhibitor, clade D (heparin cofactor), member 1 , heparin cofactor 2-like , HC-II , heparin cofactor II , protease inhibitor leuserpin-2 , serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 , serpin D1 , leuserpin 2 , leuserpin-2 , serine (or cysteine) peptidase inhibitor, clade D, member 1 , serine (or cysteine) proteinase inhibitor, clade D, member 1 , serpin peptidase inhibitor, clade D, member 1

GENE ID SPECIES
359841 Danio rerio
696950 Macaca mulatta
100467362 Ailuropoda melanoleuca
100542650 Meleagris gallopavo
100596966 Nomascus leucogenys
100629879 Equus caballus
100155945 Sus scrofa
15160 Mus musculus
3053 Homo sapiens
100682658 Canis lupus familiaris
79224 Rattus norvegicus
100009170 Oryctolagus cuniculus
100125764 Bos taurus
395877 Gallus gallus
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