anti-serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) Antibodies

The protein encoded by SERPINF1 is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. Additionally we are shipping serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Kits (81) and serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Proteins (56) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SERPINF1 5176 P36955
SERPINF1 20317 P97298
SERPINF1 287526  
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Top anti-serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Antibodies at antibodies-online.com

Showing 10 out of 167 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated IHC, WB WB Suggested Anti-SERPINF1 <br /> Antibody Titration: 0.2-1 µg/mL <br /> Positive Control: Human Placenta 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of SERPINF1 antibody (Center) (ABIN391483) in K562 cell line lysates (35 µg/lane). SERPINF1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with SERPINF1 Antibody (Center) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of SERPINF1 Antibody (N-term) (ABIN391482) in 293 cell line lysates (35 µg/lane). SERPINF1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with SERPINF1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of SERPINF1 Antibody (N-term) in 293 cell line lysates (35ug/lane). SERPINF1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot With PEDF antibody. Figure A: Lane 1: 50 µg Jurkat cell lysate. Lane 2: 50 µg 3T3 cell Lysate. Lane 3: 50 µg Mouse muscle lysate. Land 4: 50 µg Rat kidney lysate. Figure B: Lane 1: 2 ng Human recombinant PEDF Lane 2: 10 ng Human recombinant PEDF 100 μg Log in to see 2 to 3 Days
$265.00
Details
Cow Rabbit Un-conjugated WB   200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Mouse Un-conjugated EIA, IHC (p), WB Western blot analysis: A549 cell lysate was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PEDF antibody (1:1000). Protein was visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Bat Rabbit Un-conjugated IHC (p), WB Human Skin (formalin-fixed, paraffin-embedded) stained with SERPINF1 antibody ABIN337231 at 4-8 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$676.50
Details
Human Mouse Un-conjugated WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SERPINF1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SERPINF1. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Mouse Un-conjugated ELISA, WB Western Blot: Serpin F1/PEDF Antibody (1C4) [NBP1-04331] - A549 cell lysate was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PEDF antibody (1:1000). Protein was visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. 0.1 mL Log in to see 7 to 9 Days
$415.44
Details

SERPINF1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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More Antibodies against serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Interaction Partners

Human serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. Serum levels of PEDF were significantly correlated with body mass index, vasodilation and brachial artery intima-media thickness.

  2. PEDF expression in retinal endothelial cells plays a key role in modulation of cell proliferation, migration, and capillary morphogenesis.

  3. study found that PEDF binds to the C1q head regions and activates the classical complement pathway; in addition, observed that in synovial fluid (SF) from rheumatoid arthritis patients, PEDF forms detectable complexes with C4d, which are present in a range of concentrations; SF from nonarthritic donors consistently contained little or no C4d-PEDF complexes

  4. PEDF is a hormone-regulated negative autocrine mediator of endometrial proliferation.

  5. Findings suggest that PEDF plays a critical role in preventing hypoxia/reoxygenation injury by modulating anti-oxidant and anti-apoptotic factors and promoting autophagy.

  6. PEDF is associated with increased epithelial-mesenchymal transition in bladder cancer

  7. Six rare heterozygous SERPINF1 variants were found in seven patients in our familial otosclerosis cohort; three are missense mutations predicted to be deleterious to protein function

  8. Excessive amount of PEDF50 in myopic specimens have been shown to correlate with the abrogated PEDF processing rather than with an increase of its expression. Moreover, immunohistochemical staining of the myopic Tenon's capsule tissue sections revealed the halo of deposited PEDF50 in the fibroblast extracellular space.

  9. Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway may mediate ox-LDL-induced endothelial injury via oxidative stress, and PEDF ameliorates endothelial injury by suppressing Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway and subsequently reducing oxidative stress.

  10. Furthermore, pigment epithelium-derived factor (PEDF), a secreted glycoprotein known for its anti-tumor properties, blocked Wnt3a (show WNT3A Antibodies)-directed induction of autophagy proteins. Autophagy inhibition was complemented by reciprocal regulation of the oxidative stress enzymes, superoxide dismutase 2 (SOD2 (show SOD2 Antibodies)) and catalase (show CAT Antibodies).

Pig (Porcine) serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. After cryotherapy of the sclera, pigment epithelium-derived factor levels increased 44.8% compared to untreated controlsand stayed at that level until day 14. It returned to baseline by day 21. (untreated).

  2. the inhibitory effect of PEDF appears to be mediated via the processing of VEGF-R2 by gamma-secretase

Cow (Bovine) serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. PEDF inhibits key steps in the angiogenic response of retinal capillary endothelial cells, including cell proliferation and vascular tubule formation. Gene expression of PEDF is negatively regulated by glucose, insulin (via mTOR) and VEGF.

  2. Results suggest that leptin (show LEP Antibodies) might elicit angiogenesis through vascular endothelial growth factor induction as well as pigment epithelium-derived factor suppression in pericytes.

  3. PEDF promotes growth of pericytes through autocrine production of PDGFB.

  4. PEDF and VEGFR-1 (show FLT1 Antibodies) have roles in the negative regulation of angiogenesis

Horse (Equine) serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. data suggest that PEDF, via its potent antiangiogenic capabilities, may contribute to superior healing in wounds on the trunks of horses by protecting from excessive formation of vascular granulation tissue

Mouse (Murine) serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. Combination of neuroprotective factors Pedf plus docosahexaenoic acid (DHA) stimulates corneal nerve regeneration. Data suggest activation of Pedfr by Pedf (here, applied topically to treat corneal nerve injury) promotes regeneration of corneal nerve via up-regulation of release of DHA (here, also applied topically) and expression of specific nerve tissue/eye proteins. (Pedfr = pigment epithelium-derived factor receptor)

  2. The renoprotective effects of PEDF are mediated, at least partially, by inhibition of the Wnt (show WNT2 Antibodies) pathway in kidneys.

  3. PEDF deficiency has a significant impact on retinal endothelial cell adhesion and migration through altered production of extracellular matrix and junctional proteins in response to increased oxidative stress affecting their proangiogenic activity.

  4. PEDF is a hormone-regulated negative autocrine mediator of endometrial proliferation.

  5. These results indicate that PEDF counters Wnt (show WNT2 Antibodies) signaling to allow for osteoblast differentiation and provides a mechanistic insight into how the PEDF null state results in OI type VI.

  6. Furthermore, pigment epithelium-derived factor (PEDF), a secreted glycoprotein known for its anti-tumor properties, blocked Wnt3a (show WNT3A Antibodies)-directed induction of autophagy proteins. Autophagy inhibition was complemented by reciprocal regulation of the oxidative stress enzymes, superoxide dismutase 2 (SOD2 (show SOD2 Antibodies)) and catalase (show CAT Antibodies).

  7. Study demonstrated the inhibitory effect of PEDF on insulin (show INS Antibodies)-dependent molecular mechanisms of glucose homeostasis, and suggests that PEDF could be a specific target in the management of metabolic disorders.

  8. Alpha-2-Antiplasmin (show Alpha2 Antiplasmin Antibodies) mediated myofibroblast formation and the development of renal fibrosis in unilateral ureteral obstruction via induction of TGF-beta (show TGFB1 Antibodies).

  9. PEDF inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids in diabetic retinopathy.

  10. Data suggest that pigment epithelium-derived factor (PEDF) and adipose triglyceride lipase (ATGL (show PNPLA2 Antibodies)) may serve as therapeutic targets for managing vascular hyperpermeability in sepsis.

serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.

Gene names and symbols associated with SERPINF1

  • serpin family F member 1 (SERPINF1) antibody
  • serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (serpinf1) antibody
  • serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog (serpinf1.L) antibody
  • serpin family F member 1 (Serpinf1) antibody
  • serine (or cysteine) peptidase inhibitor, clade F, member 1 (Serpinf1) antibody
  • AI195227 antibody
  • Dmrs91 antibody
  • EPC-1 antibody
  • MGC82984 antibody
  • OI6 antibody
  • OI12 antibody
  • Pedf antibody
  • Pedfl antibody
  • Sdf3 antibody
  • SERPINF1 antibody
  • zgc:92072 antibody

Protein level used designations for SERPINF1

cell proliferation-inducing gene 35 protein , pigment epithelium-derived factor , serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 , serpin F1 , alpha-2 antiplasmin , pigment epithelium derived factor , serpin peptidase inhibitor, clade F, member 1 , serpin-F1 , serine (or cysteine) proteinase inhibitor, clade F), member 1 , serine (or cysteine) proteinase inhibitor, clade F, member 1 , serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 , alpha-2 antiplasmin, pigment epithelium derived factor , pigment epithelium-derived factor-like , SDF-3 , caspin , stromal cell derived factor 3 , stromal cell-derived factor 3 , serine (or cysteine) peptidase inhibitor, clade F, member 1

GENE ID SPECIES
5176 Homo sapiens
780402 Sus scrofa
281386 Bos taurus
394686 Xenopus (Silurana) tropicalis
417561 Gallus gallus
444412 Xenopus laevis
468137 Pan troglodytes
611276 Canis lupus familiaris
100072415 Equus caballus
100192425 Ovis aries
100216362 Cavia porcellus
100403187 Callithrix jacchus
100457889 Pongo abelii
100482247 Ailuropoda melanoleuca
100580793 Nomascus leucogenys
20317 Mus musculus
287526 Rattus norvegicus
447800 Danio rerio
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