serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Proteins (SERPINF1)

The protein encoded by SERPINF1 is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. Additionally we are shipping serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Antibodies (168) and serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Kits (73) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SERPINF1 57104 Q96AD5
SERPINF1 20317 P97298
SERPINF1 287526  
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Top serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Proteins at antibodies-online.com

Showing 10 out of 64 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag Human Serpin F1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 2 to 3 Days
$319.00
Details
HOST_Human Cells Mouse His tag 50 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Human His tag 50 μg Log in to see 20 to 21 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$135.88
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
HOST_HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
$615.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 10 μg Log in to see 3 to 4 Days
$85.00
Details
HOST_CHO Cells Human DYKDDDDK Tag   10 μg Log in to see 5 to 8 Days
$299.25
Details

SERPINF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , , ,
, , ,
Mouse (Murine) , ,
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Rat (Rattus) ,
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Top referenced serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Proteins

  1. Human SERPINF1 Protein expressed in HEK-293 - ABIN2666571 : Tombran-Tink, Chader, Johnson: PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity. in Experimental eye research 1991 (PubMed)
    Show all 7 references for 2666571

  2. Mouse (Murine) SERPINF1 Protein expressed in Human Cells - ABIN2007552 : Irving, Pike, Lesk, Whisstock: Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function. in Genome research 2000 (PubMed)
    Show all 3 references for 2007552

  3. Human SERPINF1 Protein expressed in HEK-293 Cells - ABIN2181751 : Duh, Yang, Suzuma, Miyagi, Youngman, Mori, Katai, Yan, Suzuma, West, Davarya, Tong, Gehlbach, Pearlman, Crabb, Aiello, Campochiaro, Zack: Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth. in Investigative ophthalmology & visual science 2002 (PubMed)
    Show all 2 references for 2181751

  4. Human SERPINF1 Protein expressed in Human Cells - ABIN2003987 : Rawlings, Tolle, Barrett: Evolutionary families of peptidase inhibitors. in The Biochemical journal 2004 (PubMed)
    Show all 2 references for 2003987

  5. Human SERPINF1 Protein expressed in Escherichia coli (E. coli) - ABIN667116 : Becerra, Sagasti, Spinella, Notario: Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop. in The Journal of biological chemistry 1995 (PubMed)
    Show all 2 references for 667116

More Proteins for serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) Interaction Partners

Horse (Equine) serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. data suggest that PEDF, via its potent antiangiogenic capabilities, may contribute to superior healing in wounds on the trunks of horses by protecting from excessive formation of vascular granulation tissue

Human serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. PEDF is a hormone-regulated negative autocrine mediator of endometrial proliferation.

  2. Findings suggest that PEDF plays a critical role in preventing hypoxia/reoxygenation injury by modulating anti-oxidant and anti-apoptotic factors and promoting autophagy.

  3. PEDF is associated with increased epithelial-mesenchymal transition in bladder cancer

  4. Six rare heterozygous SERPINF1 variants were found in seven patients in our familial otosclerosis cohort; three are missense mutations predicted to be deleterious to protein function

  5. Excessive amount of PEDF50 in myopic specimens have been shown to correlate with the abrogated PEDF processing rather than with an increase of its expression. Moreover, immunohistochemical staining of the myopic Tenon's capsule tissue sections revealed the halo of deposited PEDF50 in the fibroblast extracellular space.

  6. Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway may mediate ox-LDL-induced endothelial injury via oxidative stress, and PEDF ameliorates endothelial injury by suppressing Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway and subsequently reducing oxidative stress.

  7. Oxidative stress decreased the levels of PNPLA2 (show PNPLA2 Proteins) transcripts with no effect on ALOX5 (show ALOX5 Proteins) expression. Exogenous additions of P1 peptide or overexpression of the PNPLA2 (show PNPLA2 Proteins) gene decreased both LTB4 (show PTGR1 Proteins) levels and death of RPE (show RPE Proteins) cells undergoing oxidative stress.

  8. Furthermore, pigment epithelium-derived factor (PEDF), a secreted glycoprotein known for its anti-tumor properties, blocked Wnt3a (show WNT3A Proteins)-directed induction of autophagy proteins. Autophagy inhibition was complemented by reciprocal regulation of the oxidative stress enzymes, superoxide dismutase 2 (SOD2 (show SOD2 Proteins)) and catalase (show CAT Proteins).

  9. The results indicated that the reduction of VEGF (show VEGFA Proteins) and increase in PEDF are causative to the evolution of infantile hemangioma. PEDF may play a key role in the spontaneous regression of infantile hemangioma and may become an important potential therapeutic agent for infantile hemangioma.

  10. Results suggest that increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) expression is associated with increased adiposity and stromal proliferation in patients with pancreatic ductal adenocarcinoma (PDAC).

Mouse (Murine) serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. PEDF is a hormone-regulated negative autocrine mediator of endometrial proliferation.

  2. These results indicate that PEDF counters Wnt (show WNT2 Proteins) signaling to allow for osteoblast differentiation and provides a mechanistic insight into how the PEDF null state results in OI type VI.

  3. Furthermore, pigment epithelium-derived factor (PEDF), a secreted glycoprotein known for its anti-tumor properties, blocked Wnt3a (show WNT3A Proteins)-directed induction of autophagy proteins. Autophagy inhibition was complemented by reciprocal regulation of the oxidative stress enzymes, superoxide dismutase 2 (SOD2 (show SOD2 Proteins)) and catalase (show CAT Proteins).

  4. Study demonstrated the inhibitory effect of PEDF on insulin (show INS Proteins)-dependent molecular mechanisms of glucose homeostasis, and suggests that PEDF could be a specific target in the management of metabolic disorders.

  5. Alpha-2-Antiplasmin mediated myofibroblast formation and the development of renal fibrosis in unilateral ureteral obstruction via induction of TGF-beta (show TGFB1 Proteins).

  6. PEDF inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids in diabetic retinopathy.

  7. Data suggest that pigment epithelium-derived factor (PEDF) and adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) may serve as therapeutic targets for managing vascular hyperpermeability in sepsis.

  8. describe alterations in the PEDF signaling pathway and subventricular zone stem cell self-renewal at a very young age, which could be involved in the premature senescence observed in the SAM (show TTN Proteins)-P8 model

  9. The combination of rAAV-PEDF with hyperthermia has synergistic therapeutic effects on established solid tumors, with no side effects.

  10. PEDF mediates reduced vasculogenesis.

Pig (Porcine) serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. After cryotherapy of the sclera, pigment epithelium-derived factor levels increased 44.8% compared to untreated controlsand stayed at that level until day 14. It returned to baseline by day 21. (untreated).

  2. the inhibitory effect of PEDF appears to be mediated via the processing of VEGF-R2 by gamma-secretase

Cow (Bovine) serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. PEDF inhibits key steps in the angiogenic response of retinal capillary endothelial cells, including cell proliferation and vascular tubule formation. Gene expression of PEDF is negatively regulated by glucose, insulin (via mTOR) and VEGF.

  2. Results suggest that leptin (show LEP Proteins) might elicit angiogenesis through vascular endothelial growth factor induction as well as pigment epithelium-derived factor suppression in pericytes.

  3. PEDF promotes growth of pericytes through autocrine production of PDGFB.

  4. PEDF and VEGFR-1 (show FLT1 Proteins) have roles in the negative regulation of angiogenesis

serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.

Gene names and symbols associated with SERPINF1

  • serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (serpinf1)
  • serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (SERPINF1)
  • patatin-like phospholipase domain containing 2 (PNPLA2)
  • serine (or cysteine) peptidase inhibitor, clade F, member 1 (Serpinf1)
  • serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (Serpinf1)
  • 1110001C14Rik protein
  • AI195227 protein
  • ATGL protein
  • Dmrs91 protein
  • EPC-1 protein
  • iPLA2zeta protein
  • MGC82984 protein
  • OI6 protein
  • OI12 protein
  • Pedf protein
  • PEDF-R protein
  • Pedfl protein
  • Sdf3 protein
  • SERPINF1 protein
  • TTS-2.2 protein
  • TTS2 protein

Protein level used designations for SERPINF1

serine (or cysteine) proteinase inhibitor, clade F), member 1 , serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 , pigment epithelium derived factor , serine (or cysteine) proteinase inhibitor, clade F, member 1 , serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 , pigment epithelium-derived factor , serpin peptidase inhibitor, clade F, member 1 , pigment epithelium-derived factor-like , IPLA2-zeta , TTS2.2 , adipose triglyceride lipase , calcium-independent phospholipase A2 , desnutrin , patatin-like phospholipase domain containing protein 2 , patatin-like phospholipase domain-containing protein 2 , transport-secretion protein 2.2 , triglyceride hydrolase , SDF-3 , alpha-2 antiplasmin , caspin , serpin F1 , serpin-F1 , stromal cell derived factor 3 , stromal cell-derived factor 3 , cell proliferation-inducing gene 35 protein , serine (or cysteine) peptidase inhibitor, clade F, member 1 , alpha-2 antiplasmin, pigment epithelium derived factor

GENE ID SPECIES
394686 Xenopus (Silurana) tropicalis
444412 Xenopus laevis
468137 Pan troglodytes
771608 Gallus gallus
100072415 Equus caballus
100403187 Callithrix jacchus
100457889 Pongo abelii
100482247 Ailuropoda melanoleuca
100580793 Nomascus leucogenys
57104 Homo sapiens
20317 Mus musculus
100216362 Cavia porcellus
5176 Homo sapiens
287526 Rattus norvegicus
780402 Sus scrofa
611276 Canis lupus familiaris
281386 Bos taurus
100192425 Ovis aries
417561 Gallus gallus
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