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anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) Antibodies

SERPINI1 encodes a member of the serpin superfamily of serine proteinase inhibitors. Additionally we are shipping serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 Proteins (21) and serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SERPINI1 20713 O35684
SERPINI1 5274 Q99574
SERPINI1 116459 Q9JLD2
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Top anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 Antibodies at antibodies-online.com

Showing 10 out of 113 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SERPINI1 Antibody Titration: 0.2-1 ug/mlELISA Titer:... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB ABIN185373 (1µg/ml) staining of Human Brain lysate (35µg protein in RI... 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Confocal Immunofluorescent analysis of SERPINI1 Antibody (N-term)Cat.-... Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Hum... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chimpanzee Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated WB SERPINI1 monoclonal antibody (M03), clone 1E10. Western Blot analysis ... 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$253.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Confocal immunofluorescent analysis of SERPINI1 Antibody (N-term)(ABIN... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Image Sample(30 μg of whole cell lysate) A:A431, B:HeLa S3, C:Hep G... 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

SERPINI1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , , , ,
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Human , , , ,
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Rat (Rattus) , , ,
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Top referenced anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 Antibodies

  1. Human Polyclonal SERPINI1 Primary Antibody for EIA, IF - ABIN953686 : Takehara, Zhang, Yang, Takahashi, Mikami, Onda: Refolding and polymerization pathways of neuroserpin. in Journal of molecular biology 2010 (PubMed)
    Show all 5 references for ABIN953686

  2. Human Monoclonal SERPINI1 Primary Antibody for WB - ABIN393232 : Han, Lan, Park, Lee, Park, Ahn, Shin, Kang, Koo, Seo, Choi, Ahn, Chanock, Kim, Rothman, Kang: Polymorphisms in innate immunity genes and risk of childhood leukemia. in Human immunology 2010 (PubMed)
    Show all 5 references for ABIN393232

  3. Human Polyclonal SERPINI1 Primary Antibody for ELISA, WB - ABIN185373 : Onda, Belorgey, Sharp, Lomas: Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN185373

  4. Human Polyclonal SERPINI1 Primary Antibody for WB - ABIN2774154 : Gourfinkel-An, Duyckaerts, Camuzat, Meyrignac, Sonderegger, Baulac, Brice: Clinical and neuropathologic study of a French family with a mutation in the neuroserpin gene. in Neurology 2007 (PubMed)

  5. Human Polyclonal SERPINI1 Primary Antibody for WB - ABIN871720 : Davis, Shrimpton, Holohan, Bradshaw, Feiglin, Collins, Sonderegger, Kinter, Becker, Lacbawan, Krasnewich, Muenke, Lawrence, Yerby, Shaw, Gooptu, Elliott, Finch, Carrell, Lomas: Familial dementia caused by polymerization of mutant neuroserpin. in Nature 1999 (PubMed)

More Antibodies against serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) interaction partners

  1. Results report the identification of Spn4A, a previously uncharacterized secretory pathway serine protease inhibitor (serpin) from Drosophila melanogaster that contains a consensus furin (show FURIN Antibodies) cleavage site.

  2. Spn4 gene represents a versatile defence tool kit that may provide multiple antiproteolytic functions.

Mouse (Murine) serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) interaction partners

  1. the protective effect of neuroserpin maybe independent from its canonical interaction with a tissue-type plasminogen activator (show PLAT Antibodies)

  2. Brain metastatic cells from lung cancer and breast cancer express high levels of anti-plasminogen (show PLG Antibodies) activator (PA) serpins, including neuroserpin and serpin B2 (show SERPINB2 Antibodies), to prevent plasmin (show PLG Antibodies) generation and its metastasis-suppressive effects.

  3. Data indicate that the neuroprotective effect of neuroserpin is due to inhibition of plasmin (show PLG Antibodies)-mediated excitotoxin-induced cell death and is independent of neuroserpin's ability to inhibit tissue plasminogen activator (show PLAT Antibodies) activity.

  4. Neuroserpin reduces microglial activation and, therefore, plasminogen (show PLG Antibodies) activator levels; it has a neuroprotective role after focal ischemic stroke.

  5. Neuroserpin mRNA is widely expressed in neuronal cells in the primary visual cortex during normal development as well as in the adult mouse.

  6. Our results implicate neuroserpin in the regulation of emotional behavior through a mechanism that is at least in part independent of tissue type plasminogen activator (show PLAT Antibodies) activity

  7. neuroserpin levels appear to be carefully regulated by LRP (show LRP1 Antibodies) and an unidentified cofactor, and this pathway may be critical for maintaining the balance between proteases and inhibitors

  8. Altogether, these data suggest that an overexpression of neuroserpin in the brain parenchyma might limit the deleterious effect of tPA (show PLAT Antibodies) on NMDA receptor-mediated neuronal death, which occurs following experimental ischemia.

  9. Transgenic mice overexpressing neuroserpin have decreased plasminogen (show PLG Antibodies) activators in sciatic nerve and spinal cord, confirming a role for neuroserpin in the evolution of a neurodegenerative disease.

  10. the existence of an AMH (show AMH Antibodies)-dependent signalling pathway in the brain leading to an overexpression of the serine-protease inhibitor, neuroserpin, and neuronal survival

Human serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) interaction partners

  1. This C-terminal lability is not required for neuroserpin polymerisation in the endoplasmic reticulum, but the additional glycan facilitates degradation of the mutant protein during proteasomal impairment.

  2. the protective effect of neuroserpin maybe independent from its canonical interaction with a tissue-type plasminogen activator (show PLAT Antibodies)

  3. Neuroserpin is expressed in naive effector memory and central memory CD4 (show CD4 Antibodies) and CD8 (show CD8A Antibodies) T cell subsets, and monocytes, B cells, and NK cells. T-cell activation caused its translocation to the immunologic synapse, secretion, and delayed downregulation.

  4. Molecular Dynamics simulations suggest that Neuroserpin conformational stability and flexibility arise from a spatial distribution of intramolecular salt-bridges and hydrogen bonds.

  5. Alzheimer's disease brain tissues with elevated neuroserpin protein also showed increased expression of THRbeta1 and HuD (show ELAVL4 Antibodies)

  6. our study did not provide any evidence for an association between genetic variation at the SERPINI1 locus and ischemic stroke

  7. Neuroprotective properties of neuroserpin may be related to the inhibition of excitotoxicity, inflammation, as well as blood brain barrier disruption that occur after acute ischemic stroke.

  8. Hrd1 (show SYVN1 Antibodies) and gp78 (show AMFR Antibodies) mediate mutant neuroserpin turnover through the ERAD pathway.

  9. high serum neuroserpin levels before intravenous tPA (show PLAT Antibodies) and neuroserpin levels decrease at 24 h after ischaemic stroke, independently of tPA (show PLAT Antibodies) treatment, may have a role in good functional outcome

  10. The latent and polymer hNS forms obtained at 45 degrees C and 85 degrees C differ in their chemical and thermal stabilities; furthermore, the human neuroserpin polymers also differ in size and morphology

serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) Antigen Profile

Protein Summary

This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with SERPINI1

  • Serpin 42Da (Spn42Da) antibody
  • serpin peptidase inhibitor, clade I (neuroserpin), member 1 (SERPINI1) antibody
  • serpin peptidase inhibitor, clade I (neuroserpin), member 1 (serpini1) antibody
  • neuroserpin (LOC100341797) antibody
  • neuroserpin (LOC100154352) antibody
  • serine (or cysteine) peptidase inhibitor, clade I, member 1 (Serpini1) antibody
  • serpin peptidase inhibitor, clade I (neuroserpin), member 1 (Serpini1) antibody
  • AI837402 antibody
  • CG9453 antibody
  • Dmel\\CG9453 antibody
  • dSerp2 antibody
  • neuroserpin antibody
  • Ns antibody
  • PI-12 antibody
  • PI12 antibody
  • raPIT5a antibody
  • Serp2 antibody
  • SERPINI1 antibody
  • sp4 antibody
  • Spi17 antibody
  • spn4 antibody
  • Spn4A antibody

Protein level used designations for SERPINI1

CG9453-PA , CG9453-PB , CG9453-PD , CG9453-PE , CG9453-PF , CG9453-PG , CG9453-PH , CG9453-PI , CG9453-PJ , CG9453-PK , CG9453-PL , Serp2 , Spn42Da-PA , Spn42Da-PB , Spn42Da-PD , Spn42Da-PE , Spn42Da-PF , Spn42Da-PG , Spn42Da-PH , Spn42Da-PI , Spn42Da-PJ , Spn42Da-PK , Spn42Da-PL , neuroserpin , serine protease inhibitor 4 , serpin 4 , serpin 42Da , serpin peptidase inhibitor, clade I (neuroserpin), member 1 , neuroserpin-like , peptidase inhibitor 12 , protease inhibitor 17 , serine protease inhibitor 17 , serpin I1 , PI-12 , serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1 , serine (or cysteine) peptidase inhibitor, clade I, member 1 , serine (or cysteine) proteinase inhibitor clade member 1 , serpin peptidase inhibitor, clade I, member 1 , axonin-2

GENE ID SPECIES
49805 Drosophila melanogaster
699483 Macaca mulatta
100057410 Equus caballus
100144746 Xenopus (Silurana) tropicalis
100341797 Oryctolagus cuniculus
100406302 Callithrix jacchus
100458391 Pongo abelii
100481992 Ailuropoda melanoleuca
100589442 Nomascus leucogenys
100154352 Sus scrofa
20713 Mus musculus
5274 Homo sapiens
509976 Bos taurus
116459 Rattus norvegicus
460834 Pan troglodytes
425002 Gallus gallus
478684 Canis lupus familiaris
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