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SGK3 is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. Additionally we are shipping serum/glucocorticoid Regulated Kinase Family, Member 3 Antibodies (122) and serum/glucocorticoid Regulated Kinase Family, Member 3 Proteins (12) and many more products for this protein.
SGK3 is a positive regulator of KCNA5, which is at least partially effective by abrogating the effect of Nedd4-2.
SGK3 contributes to the regulation of store-operated calcium entry into and migration of dendritic cells.
SGK3 plays a previously unappreciated role in glucose homeostasis, likely through direct effects within pancreatic beta-cells, to stimulate proliferation and insulin (show INS ELISA Kits) release
The study identifies SGK3 as a novel endosomal kinase that acutely regulates Na(+)/H(+) exchanger 3 (NHE3 (show SLC9A3 ELISA Kits)) in a PI3K-dependent mechanism.
SGK3 has a subtle but significant role in the regulation of renal tubular phosphate transport and bone density.
Data suggest that SGK3 is critical for proper mast cell function.
SGK3 plays an important role in postnatal hair follicle development as illustrated by SGK3 knockout mice. The hair defect is linked to reduced proliferation and reduced nuclear accumulation of beta catenin (show CTNNB1 ELISA Kits) in hair bulb keratinocytes.
SGK3 is differentially regulated in hippocampus after contextual fear conditioning & reactivation of the context-shock memory. Consolidation changes are recapitulated during reconsolidation. Retrieval-induced transcription depends on memory remoteness.
SGK3, and to a lesser extent SGK2 (show SGK2 ELISA Kits), but not SGK1 (show SGK1 ELISA Kits), increase glutamate (show GRIN1 ELISA Kits)-induced currents by increasing the abundance of GluR1 (show GRIA1 ELISA Kits) protein in the cell membrane
SGK3 is required for adequate intestinal Na(+) coupled glucose transport and impaired glucose absorption may contribute to delayed growth and decreased plasma glucose concentrations of SGK3 deficient mice.
Data show that activation of serum- and glucocorticoid-regulated kinase 3 (SGK3) plays an important role in inositol polyphosphate 4-phosphatase type II (INPP4B (show INPP4B ELISA Kits))-mediated melanoma cell proliferation.
It is unlikely that SGK3 plays a significant role for oncogenic signalling in multiple myeloma.
SGK3 is a key mediator of PDK1 (show PDK1 ELISA Kits) activity in melanoma.
VPS34 (show PIK3C3 ELISA Kits)-IN1 will provide a useful tool to decipher the kinase-dependent functions of Vps34 (show PIK3C3 ELISA Kits), with acute changes in SGK3 phosphorylation and subcellular localization being new biomarkers of Vps34 (show PIK3C3 ELISA Kits) activity
Breast cancers harboring oncogenic PIK3CA (show PIK3CA ELISA Kits) activate SGK3 signaling while suppressing Akt (show AKT1 ELISA Kits), indicative of oncogenic functions for both INPP4B (show INPP4B ELISA Kits) and SGK3 in these tumors.
SGK3 is an androgen receptor (AR (show AR ELISA Kits)) target and induces cell proliferation through the AR-SGK3-p70S6K (show RPS6KB1 ELISA Kits)-cyclin D1 (show CCND1 ELISA Kits) pathway in prostate cancer cells.
SGK3 is a novel regulator of K(ir)2.1.
SGK3 stability and kinase activation are regulated by the Hsp90 (show HSP90 ELISA Kits)-Cdc37 (show CDC37 ELISA Kits) chaperone complex.
SGK1,3 enhances the expression level of mature hERG (show KCNH2 ELISA Kits) channels by inhibiting Nedd4-2 as well as by promoting Rab11 (show RAB11A ELISA Kits)-mediated hERG (show KCNH2 ELISA Kits) recycling.
A positive correlation between SGK3 expression and breast tumor prognosis.
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
serine/threonine-protein kinase Sgk3
, cytokine-independent survival kinase
, serine/threonine protein kinase CISK
, serum/glucocorticoid-regulated kinase 3
, serum/glucocorticoid regulated kinase 3
, serum glucocorticoid regulated kinase 3