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sigma Non-Opioid Intracellular Receptor 1 Proteins (SIGMAR1)

SIGMAR1 encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. Additionally we are shipping SIGMAR1 Antibodies (28) and SIGMAR1 Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIGMAR1 10280 Q99720
SIGMAR1 18391 O55242
Rat SIGMAR1 SIGMAR1 29336 Q9R0C9
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Top SIGMAR1 Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,031.33
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,031.33
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,042.33
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,042.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SIGMAR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,

More Proteins for sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) Interaction Partners

Human sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. Collectively, these studies define Sig1R as a key mediator of TRAIL induction of cancer-specific killing.

  2. crystal structures of the human sigma1 receptor in complex with two chemically divergent ligands, PD144418 and 4-IBP (show TSPO Proteins)

  3. Expression of mutant Sig-1R protein reduces mitochondrial ATP production, inhibits proteasome activity and causes mitochondrial injury, aggravating ER stress-induced neuronal death.

  4. Removal of the S1R gene in the Superoxide Dismutase-1 (SOD-1 (show SOD1 Proteins)) mouse model of ALS (show IGFALS Proteins) exacerbated the neurodegenerative condition and resulted in a significantly reduced longevity.

  5. mutations of the SIGMAR1 gene worsen outcome in Alzheimer's disease and myotrophic lateral sclerosis supporting a role of Sig-1R in neurodegenerative disease.

  6. examined blood samples from 3081 ischemic stroke (IS) patients and 1595 control subjects regarding 10 single nucleotide polymorphisms (SNPs) in the APOD (show APOD Proteins) and SIGMAR1 genes to find possible associations with IS risk, IS severity and recovery after IS

  7. Central and peripheral pharmacological blockade of Sig-1R could be an effective option to treat inflammatory pain--{REVIEW}

  8. Results suggest that the ubiquitin-proteasome pathway is implicated in nuclear inclusion formation, and that SIGMAR1 degrades aberrant proteins in the nucleus via the endoplasmic reticulum-related degradation machinery

  9. Homozygous c.151+1G>T mutation in SIGMAR1 caused a novel form of autosomal recessive distal hereditary motor neuropathy (dHMN) in a Chinese consanguineous family; endoplasmic reticulum stress may have a role in the pathogenesis of dHMN

  10. Patients with hilar cholangiocarcinoma overexpressed Sig1R and had an earlier recurrence and worse overall survival than those not overexpressing Sig1R.

Mouse (Murine) sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. Results suggest that Sig (show PICALM Proteins)-1Rs modulate ethanol drinking, locomotor stimulation and conditioned taste aversion, strengthening the notion that drugs acting on the Sig-1R system may have potential for treating alcohol-use disorders

  2. Sig-1R was moderately expressed in pyramidal neurons in hippocampal regions CA3 (show CA3 Proteins) and CA1 (show CA1 Proteins) and faintly in DG granule cells. Fluvoxamine or SA4503 treatment but not paroxetine restores decrease in Sig-1R and ATP production in the DG of CaMKIV (show CAMK4 Proteins) null mice.

  3. The neuroprotective role of sigma1R may be linked directly to the oxidative stress-mediating properties of supportive glial cells.

  4. Results indicate that the sigma1R deficiency impairs neurogenesis leading to a depressive-like phenotype, which is alleviated by the neuroprotection of estradiol

  5. The sigma-1R deficiency through suppressing NR2B (show GRIN2B Proteins) function and DAT (show SLC6A3 Proteins) expression can reduce MPTP (show PTPN2 Proteins)-induced death of dopaminergic neurons and parkinsonism.

  6. These results demonstrate a role of Sig-1R in transcriptional regulation.

  7. The sigma1R antagonists enhance opioid analgesia in naive mice by releasing mu-opioid receptors from the negative influence of NMDARs, and they also reset antinociception in morphine tolerant animals.

  8. Allosteric modulation of sigma-1 receptors by SKF83959 inhibits mouse BV2-microglia-mediated inflammation.

  9. provide a mechanistic explanation that Sig-1Rs help maintain proper tau phosphorylation by potentially carrying and providing myristic acid to p35 for enhanced p35 degradation to circumvent the formation of overreactive cdk5/p25

  10. In a neuropathic pain model, OPRS1 activates astrocytes via p38 MAPK (show MAPK14 Proteins) phosphorylation, leading to development of mechanical allodynia.

Cow (Bovine) sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. Sig1R through Rac1 signaling induces mild oxidative stress that possibly is involved in the regulation of neuroplasticity

Guinea Pig sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. S1R has a GXXXG motif in its second transmembrane region, and these motifs are often involved in oligomerization of membrane proteins. Disrupting mutations within the GXXXG motif shifted the fraction of the higher oligomeric states toward smaller states.

SIGMAR1 Protein Profile

Protein Summary

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor\; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.

Gene names and symbols associated with SIGMAR1

  • sigma non-opioid intracellular receptor 1 (SIGMAR1)
  • sigma non-opioid intracellular receptor 1 (Sigmar1)
  • sigma non-opioid intracellular receptor 1 (LOC100341228)
  • sigma non-opioid intracellular receptor 1 (sigmar1)
  • sigma non-opioid intracellular receptor 1-like (LOC100521392)
  • AL024364 protein
  • ALS16 protein
  • mSigmaR1 protein
  • oprs1 protein
  • SIG-1R protein
  • Sigma1R protein
  • SR-BP protein
  • SR-BP1 protein
  • SRBP protein
  • zgc:56378 protein

Protein level used designations for SIGMAR1

SR31747 binding protein 1 , aging-associated gene 8 protein , hSigmaR1 , sigma 1-type opioid receptor , opioid receptor, sigma 1 , sigma1-receptor , sigma1R , Sigma 1-type opioid receptor , Sigma1-receptor , sigma1-receptor (sterol-isomerase like protein) , sterol isomerase-like protein

GENE ID SPECIES
10280 Homo sapiens
18391 Mus musculus
29336 Rattus norvegicus
481587 Canis lupus familiaris
538903 Bos taurus
100859748 Gallus gallus
100135589 Cavia porcellus
100341228 Oryctolagus cuniculus
101116710 Ovis aries
446848 Xenopus laevis
393952 Danio rerio
100521392 Sus scrofa
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