anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) Antibodies

SIGMAR1 encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. Additionally we are shipping SIGMAR1 Kits (17) and SIGMAR1 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIGMAR1 10280 Q99720
SIGMAR1 18391 O55242
SIGMAR1 29336 Q9R0C9
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Top anti-SIGMAR1 Antibodies at antibodies-online.com

Showing 10 out of 35 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of OPRS1 (arrow) using rabbit polyclonal OPRS1 Antibody (N-term) (ABIN389221).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the OPRS1 gene (Lane 2) (Origene Technologies). Flow cytometric analysis of NCI-H292 cells using OPRS1 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of OPRS1 (arrow) using rabbit polyclonal OPRS1 Antibody (Center) (ABIN389222).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the OPRS1 gene (Lane 2) (Origene Technologies). OPRS1 Antibody (Center) (ABIN389222) western blot analysis in mouse brain tissue lysates (35 µg/lane).This demonstrates the OPRS1 antibody detected the OPRS1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti Sigma1R/OPRS1/Sigma Receptor Polyclonal Antibody, Unconjugated (ABIN709841) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti Sigma1R/OPRS1/Sigma Receptor Polyclonal Antibody, Unconjugated (ABIN709841) at 1:200, overnight at 4°C. The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37°C. 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Rabbit Un-conjugated IHC, IHC (p), SimWes, WB Simple Western: Sigma-1 R/OPRS1 Antibody [NBP1-82479] - Electropherogram image(s) of corresponding Simple Western lane view. Sigma-1 R/OPRS1 antibody was used at 1:20 dilution on RT-4 lysate(s). Simple Western: Sigma-1 R/OPRS1 Antibody [NBP1-82479] - Simple Western lane view shows a specific band for SIGMAR1 in 0.2 mg/ml of Liver (left), RT-4 (right) lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: OPRS1 Antibody [NBP2-19628] - Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using antibody at 1:100 dilution. Western Blot: OPRS1 Antibody [NBP2-19628] - Sample (30 ug of whole cell lysate) A: 293T 12% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of Sigma1 Receptor expression in Hela (A), SW620 (B), HepG2 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: Sigma-1 R/OPRS1 Antibody [NBP1-82480] - Staining of human liver shows strong cytoplasmic positivity in hepatocytes. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated WB Western blot analysis of OPRS1 using rabbit polyclonal OPRS1 Antibody.293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the OPRS1 gene (Lane 2). Western blot analysis in mouse brain tissue lysates (35ug/lane). 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.2 mL Log in to see 6 to 8 Days
$533.50
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 11 to 16 Days
$594.00
Details

SIGMAR1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human ,


Mouse (Murine)


Rat (Rattus)


Top referenced anti-SIGMAR1 Antibodies

  1. Human Polyclonal SIGMAR1 Primary Antibody for IHC, IHC (p) - ABIN4353782 : Sun, Kawahara, Nagamune: Modeling tandem AAG8-MEK inhibition in melanoma cells. in Cancer medicine 2014 (PubMed)
    Show all 2 references for 4353782

  2. Human Polyclonal SIGMAR1 Primary Antibody for WB - ABIN389222 : Cobos, del Pozo, Baeyens: Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells. in Journal of neurochemistry 2007 (PubMed)

More Antibodies against SIGMAR1 Interaction Partners

Human sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. These findings indicate that a loss of Sig1R function is causative for juvenile amyotrophic lateral sclerosis (ALS16), and collapse of the mitochondria-associated membrane is a common pathomechanism in both Sig1R- and SOD1-linked ALS.

  2. Analyses of tissue microarray from colorectal cancer patients showed higher SigmaR1 expression levels in cancer samples and a correlation with tumor grade. Moreover, the exploration of a cohort of 4937 breast cancer patients indicated that high expression of SigmaR1 and Orai1 (show ORAI1 Antibodies) channels was significantly correlated to a lower overall survival.

  3. Genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with Major Depressive Disorder and Bipolar Disorder.

  4. Data demonstrate the involvement of SIGMAR1 in motor neuron maintenance and survival by correlating mutations in this gene to distal motor dysfunction and highlight the chaperone activity of sigma-1R as a critical aspect in distal hereditary motor neuropathy pathology.

  5. Changes of Sig1R and SOD2 (show SOD2 Antibodies) expression point to mitochondria as main organelle responsible for survival of tumor cells exposed to hypoxia or oxidative stress. Studied proteins are involved in intracellular response to stress related with different concentrations of oxygen.

  6. Collectively, these studies define Sig1R as a key mediator of TRAIL induction of cancer-specific killing.

  7. crystal structures of the human sigma1 receptor in complex with two chemically divergent ligands, PD144418 and 4-IBP (show TSPO Antibodies)

  8. Expression of mutant Sig-1R protein reduces mitochondrial ATP production, inhibits proteasome activity and causes mitochondrial injury, aggravating ER stress-induced neuronal death.

  9. Removal of the S1R (show TMBIM4 Antibodies) gene in the Superoxide Dismutase-1 (SOD-1 (show SOD1 Antibodies)) mouse model of ALS (show IGFALS Antibodies) exacerbated the neurodegenerative condition and resulted in a significantly reduced longevity.

  10. mutations of the SIGMAR1 gene worsen outcome in Alzheimer's disease and myotrophic lateral sclerosis supporting a role of Sig-1R in neurodegenerative disease.

Mouse (Murine) sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. Findings identified five alternatively spliced variants of the sigma1 receptor gene Sigmar1 using a polymerase chain reaction cloning approach.

  2. inhibition of Sig (show PICALM Antibodies)-1 R prevented cocaine-induced TrkB (show NTRK2 Antibodies) activation in hippocampal neurons.

  3. Activation of S1R (show TMBIM4 Antibodies), necessary for its effect on the BDNF (show BDNF Antibodies) pathway, represents a core component of the mode of action of pridopidine. Since the newly identified pathways are downregulated in neurodegenerative diseases, including Huntington Disease (HD (show HTT Antibodies)) , these findings suggest that pridopidine may exert neuroprotective effects beyond its role in alleviating some symptoms of HD.

  4. Findings demonstrate that spinal cord injury activates astrocyte sigma-1 receptors leading to increases in the expression of the gap junction protein, connexin 43 (show GJA1 Antibodies) and astrocyte activation in the lumbar dorsal horn, and ultimately contribute to the induction of bilateral below-level mechanical allodynia.

  5. Study found: sigma-1 receptor is abundant in dorsal root ganglion (DRG) neuronal soma, but not in satellite cells; sigma-1 receptor is absent in processes of DRG neurons; in DRG neurons, S1R (show TMBIM4 Antibodies) targets endoplasmic reticulum, nuclear envelope, and plasma membrane.

  6. The findings indicate that the activation of sigma1R can alleviate postpartum "depression" through increasing nNOS (show NOS1 Antibodies)-NO-CREB (show CREB1 Antibodies) activities.

  7. Sigma1R may be a novel retinal stress modulator, and targeting it even after disease onset may afford retinal neuroprotection.

  8. Study focused on sigma-1 receptor (Sig-1R), a chaperone at endoplasmic reticulum, and investigated its protective functions; results reveal that zinc finger protein 179 (show RNF112 Antibodies) plays a novel role in neuroprotection.

  9. the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity

  10. Results suggest that Sig (show PICALM Antibodies)-1Rs modulate ethanol drinking, locomotor stimulation and conditioned taste aversion, strengthening the notion that drugs acting on the Sig-1R system may have potential for treating alcohol-use disorders

Cow (Bovine) sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. Sig1R through Rac1 signaling induces mild oxidative stress that possibly is involved in the regulation of neuroplasticity

Guinea Pig sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. S1R (show TMBIM4 Antibodies) has a GXXXG motif in its second transmembrane region, and these motifs are often involved in oligomerization of membrane proteins. Disrupting mutations within the GXXXG motif shifted the fraction of the higher oligomeric states toward smaller states.

SIGMAR1 Antigen Profile

Protein Summary

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor\; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.

Gene names and symbols associated with SIGMAR1

  • sigma non-opioid intracellular receptor 1 (SIGMAR1) antibody
  • sigma non-opioid intracellular receptor 1 (Sigmar1) antibody
  • sigma non-opioid intracellular receptor 1 (LOC100341228) antibody
  • sigma non-opioid intracellular receptor 1 (sigmar1) antibody
  • sigma non-opioid intracellular receptor 1-like (LOC100521392) antibody
  • AL024364 antibody
  • ALS16 antibody
  • mSigmaR1 antibody
  • oprs1 antibody
  • SIG-1R antibody
  • Sigma1R antibody
  • SR-BP antibody
  • SR-BP1 antibody
  • SRBP antibody
  • zgc:56378 antibody

Protein level used designations for SIGMAR1

SR31747 binding protein 1 , aging-associated gene 8 protein , hSigmaR1 , sigma 1-type opioid receptor , opioid receptor, sigma 1 , sigma1-receptor , sigma1R , Sigma 1-type opioid receptor , Sigma1-receptor , sigma1-receptor (sterol-isomerase like protein) , sterol isomerase-like protein

GENE ID SPECIES
10280 Homo sapiens
18391 Mus musculus
29336 Rattus norvegicus
481587 Canis lupus familiaris
538903 Bos taurus
100859748 Gallus gallus
100135589 Cavia porcellus
100341228 Oryctolagus cuniculus
101116710 Ovis aries
446848 Xenopus laevis
393952 Danio rerio
100521392 Sus scrofa
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