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TTBK2 encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Additionally we are shipping TTBK2 Antibodies (64) and TTBK2 Kits (4) and many more products for this protein.
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Study shows that TTBK2 is a dedicated regulator of the initiation of cili (show USP14 Proteins)ogenesis in vivo; TTBK2 acts at the distal end of the basal body, where it promotes the removal of CP110, which caps the mother centriole, and promotes recruitment of intraflagellar transport proteins.
TTBK2 down-regulates GluK2 (show GRIK2 Proteins) activity by decreasing the receptor protein abundance in the cell membrane via RAB5 (show RAB5A Proteins)-dependent endocytosis.
TTBK1 (show Ttbk1 Proteins)/2 kinases may represent attractive targets for therapeutic intervention for TDP-43 (show TARDBP Proteins) proteinopathies such as Amyotrophic lateral sclerosis and Frontotemporal lobar degeneration-TDP.
TTBK2 is a multifunctional kinase involved in important cellular processes and demands augmented efforts in investigating its functions
TTBK2 phosphorylates KIF2A (show KIF2A Proteins) and antagonizes KIF2A (show KIF2A Proteins)-induced depolymerization at microtubules plus ends for cell migration.
TTBK2 bound EB1 and Cep164 through its SxIP motifs and a proline-rich motif, respectively.
data suggest that TTBK2 also acts upstream of Cep164, contributing to the assembly of distal appendages
Dominant truncating mutations in human TTBK2 cause spinocerebellar ataxia (show USP14 Proteins) type 11 (SCA11); these mutant proteins do not promote ciliogenesis and inhibit ciliogenesis in wild-type cells.
TTBK2 is a completely novel regulator of Na(+)-coupled glucose transport.
findings reveals a major role of PRKX (show PRKX Proteins), TTBK2 and RSK4 (show RPS6KA6 Proteins) in triggering Sunitinib resistance formation; data suggest transcriptional regulation of these kinases together with other proteins might play an important role in formation of Sunitinib resistance by affecting transcription factors
two-basepair deletion (c.1306_1307delGA, p.D435fs448X in exon 12) lead to a premature stop codon in the TTBK2 gene; spinocerebellar ataxia (show USP14 Proteins) patients had phenotypic of slowly progressive almost pure cerebellar ataxia (show USP14 Proteins) with normal life expectancy
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11)\; a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem.
tau tubulin kinase 2
, tau-tubulin kinase 2
, protein bartleby
, tau tubulin kinase 1