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TTBK2 encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Additionally we are shipping TTBK2 Proteins (7) and TTBK2 Kits (6) and many more products for this protein.
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Human Polyclonal TTBK2 Primary Antibody for ICC, IF - ABIN4357930
Čajánek, Nigg: Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole. in Proceedings of the National Academy of Sciences of the United States of America 2014
Show all 2 Pubmed References
Study shows that TTBK2 is a dedicated regulator of the initiation of ciliogenesis in vivo; TTBK2 acts at the distal end of the basal body, where it promotes the removal of CP110, which caps the mother centriole, and promotes recruitment of intraflagellar transport proteins.
TTBK2 down-regulates GluK2 (show GRIK2 Antibodies) activity by decreasing the receptor protein abundance in the cell membrane via RAB5 (show RAB5A Antibodies)-dependent endocytosis.
TTBK1 (show Ttbk1 Antibodies)/2 kinases may represent attractive targets for therapeutic intervention for TDP-43 (show TARDBP Antibodies) proteinopathies such as Amyotrophic lateral sclerosis and Frontotemporal lobar degeneration-TDP.
TTBK2 is a multifunctional kinase involved in important cellular processes and demands augmented efforts in investigating its functions
TTBK2 phosphorylates KIF2A (show KIF2A Antibodies) and antagonizes KIF2A (show KIF2A Antibodies)-induced depolymerization at microtubules plus ends for cell migration.
TTBK2 bound EB1 (show MAPRE2 Antibodies) and Cep164 (show CEP164 Antibodies) through its SxIP motifs and a proline-rich motif, respectively.
data suggest that TTBK2 also acts upstream of Cep164 (show CEP164 Antibodies), contributing to the assembly of distal appendages
Dominant truncating mutations in human TTBK2 cause spinocerebellar ataxia type 11 (SCA11); these mutant proteins do not promote ciliogenesis and inhibit ciliogenesis in wild-type cells.
TTBK2 is a completely novel regulator of Na(+)-coupled glucose transport.
findings reveals a major role of PRKX (show PRKX Antibodies), TTBK2 and RSK4 (show RPS6KA6 Antibodies) in triggering Sunitinib resistance formation; data suggest transcriptional regulation of these kinases together with other proteins might play an important role in formation of Sunitinib resistance by affecting transcription factors
two-basepair deletion (c.1306_1307delGA, p.D435fs448X in exon 12) lead to a premature stop codon in the TTBK2 gene; spinocerebellar ataxia patients had phenotypic of slowly progressive almost pure cerebellar ataxia with normal life expectancy
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11)\; a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem.
tau tubulin kinase 2
, tau-tubulin kinase 2
, protein bartleby
, tau tubulin kinase 1