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Trex2 encodes a protein with 3' exonuclease activity. Additionally we are shipping and many more products for this protein.
Showing 10 out of 42 products:
Human Polyclonal Trex2 Primary Antibody for EIA, IHC (p) - ABIN501038
Mazur, Perrino: Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. in The Journal of biological chemistry 1999
Human Polyclonal Trex2 Primary Antibody for IHC (p), IHC - ABIN450078
de Silva, Choudhury, Bailey, Harvey, Perrino, Hollis: The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering. in The Journal of biological chemistry 2007
Altogether, data provide new insights in the molecular mechanisms of TREX2 activity and establish cell autonomous and non-cell autonomous functions of TREX2 in the UVB-induced skin response.
human TREX-2 complex prevents genome instability, as determined by the accumulation of gamma-H2AX (show H2AFX Antibodies) and 53BP1 (show TP53BP1 Antibodies) foci and single-cell electrophoresis in cells depleted of the TREX-2 subunits PCID2 (show PCID2 Antibodies), GANP (show MCM3AP Antibodies) and DSS1 (show SHFM1 Antibodies)
TREX-2 is an NPC (show NPC1 Antibodies)-associated complex in mammalian cells.
Trex2 does not enable DSB repair and prompt a new model that posits Trex2 suppresses the formation of broken chromosomes.
analysis of human TREX2 3' -> 5'-exonuclease (show EXOSC10 Antibodies) structure and description of the mechanism for efficient nonprocessive DNA catalysis
Results suggest that TREX2 plays an important function during DNA metabolism and cellular proliferation.
analysis of cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease (show EXOSC10 Antibodies)
Trex2 deletion caused high levels of Robertsonian translocations (RbTs) showing Trex2 is important for chromosomal maintenance.
a model for DNA binding and 3' hydrolysis for the TREX2 dimer.
A tumor suppressor role for TREX2 in skin carcinogenesis through which it contributes to keratinocyte apoptosis under conditions of genotoxic stress.
This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.
3'-5' exonuclease TREX2 long form
, 3'-5' exonuclease TREX2