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THNSL2 encodes a threonine synthase-like protein. Additionally we are shipping threonine Synthase-Like 2 (S. Cerevisiae) Proteins (6) and many more products for this protein.
Showing 10 out of 32 products:
Human Polyclonal THNSL2 Primary Antibody for ELISA, WB - ABIN4359203
Rifas, Weitzmann: A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner. in Arthritis and rheumatism 2009
Our results provide evidence for new loci influencing abdominal visceral (BBS9 (show BBS9 Antibodies), ADCY8 (show ADCY8 Antibodies), KCNK9 (show KCNK9 Antibodies)) and subcutaneous (MLLT10 (show MLLT10 Antibodies)/DNAJC1 (show DNAJC1 Antibodies)/EBLN1 (show EBLN2 Antibodies)) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women.
THNSL2 was found to have bimodal expression in human skeletal muscle tissue.
A cytokine named SOFAT (secreted osteoclastogenic factor of activated T cells) can induce osteoblastic IL-6 (show IL6 Antibodies) production and osteoclast formation in the absence of osteoblasts or RANKL (show TNFSF11 Antibodies). It is insensitive to RANKL (show TNFSF11 Antibodies) inhibitor osteoprotegerin (show TNFRSF11B Antibodies).
This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants.
, threonine synthase-like 2
, secreted osteoclastogenic factor of activated T cells