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TNK2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. Additionally we are shipping tyrosine Kinase, Non-Receptor, 2 Kits (20) and tyrosine Kinase, Non-Receptor, 2 Proteins (8) and many more products for this protein.
Showing 10 out of 204 products:
Human Polyclonal TNK2 Primary Antibody for EIA - ABIN358513
Wolf-Yadlin, Hautaniemi, Lauffenburger, White: Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 4 references for ABIN358513
Human Polyclonal TNK2 Primary Antibody for DB - ABIN650839
Huang, Mukasa, Bonavia, Flynn, Brewer, Cavenee, Furnari, White: Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 3 references for ABIN650839
Human Polyclonal TNK2 Primary Antibody for DB - ABIN389970
Goss, Lee, Moritz, Nardone, Spek, MacNeill, Rush, Comb, Polakiewicz: A common phosphotyrosine signature for the Bcr-Abl kinase. in Blood 2006
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Human Polyclonal TNK2 Primary Antibody for WB - ABIN657857
Mahajan, Mahajan: Shepherding AKT and androgen receptor by Ack1 tyrosine kinase. in Journal of cellular physiology 2010
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Human Polyclonal TNK2 Primary Antibody for FACS, IHC (p) - ABIN392082
Yokoyama, Miller: Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck. in The Journal of biological chemistry 2003
Show all 2 references for ABIN392082
Human Polyclonal TNK2 Primary Antibody for WB - ABIN392084
Manser, Leung, Salihuddin, Tan, Lim: A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. in Nature 1993
Show all 2 references for ABIN392084
Ack1 overexpression promotes metastasis in hepatocellular carcinoma.
Results found that the expression of ACK1 was significantly up-regulated in non-small-cell lung cancer (NSCLC) samples and demonstrate that ACK1 played an oncogenic role in the progression of NSCLC.
Authors identified tyrosine kinase (show TXK Antibodies) nonreceptor 2 (TNK2) point mutations that exhibited oncogenic capacity.
that the cdc42 (show CDC42 Antibodies)-activated, nonreceptor tyrosine kinase (show TXK Antibodies), Ack1, is a DAT (show SLC6A3 Antibodies) endocytic brake that stabilizes DAT (show SLC6A3 Antibodies) at the plasma membrane.
TNK2 (and TNR (show TNR Antibodies)) harbored rare, genetic variants in individuals with familial Parkinson's Disease.
Our results indicate that ACK1 is an independent prognostic marker and promotes hepatocellular carcinoma progression
Studies indicate that activated CDC42 kinase 1 (ACK1) interacts with the estrogen receptor (ER (show ESR1 Antibodies)) and regulates the activity of androgen receptor (AR (show AR Antibodies)) to promote the growth of breast cancer and prostate cancer.
expression of Ack1 plays an important role as predictor of recurrence and poor outcome in hepatocellular carcinoma patients.
ACK1 promotes EMT, migration, and invasion by activating AKT-POU2F1-ECD signalling in Gastric cancer cells. ACK1 may be employed as a new prognostic factor and therapeutic target for gastric cancer.
We uncovered ten new mutations in TNK2 and DDR1 (show DDR1 Antibodies) within serous and endometrioid ECs, thus providing novel insights into the mutation spectrum of each gene in EC.
that the cdc42 (show CDC42 Antibodies)-activated, nonreceptor tyrosine kinase (show TYRO3 Antibodies), Ack1, is a DAT (show SLC6A3 Antibodies) endocytic brake that stabilizes DAT (show SLC6A3 Antibodies) at the plasma membrane.
ACK1 directly binds and phosphorylates the Arp2 (show AICDA Antibodies)/3 regulatory protein (show TGFB1 Antibodies) cortactin (show CTTN Antibodies), potentially providing a direct link to Arp2 (show AICDA Antibodies)/3-based actin dynamics during EGFR (show EGFR Antibodies) degradation.
Ack1-mediated androgen receptor (show AR Antibodies) phosphorylation modulates radiation resistance in castration-resistant prostate cancer
Ack1 mediated AKT/PKB (show AKT1 Antibodies) tyrosine 176 phosphorylation regulates its activation
Ack1/Pyk1 tyrosine kinase (show TYRO3 Antibodies) may be involved both in adult synaptic function and plasticity and in brain development.
Ack1 is up-regulated during development and is expressed in proliferative areas and in migratory pathways in the developing brain.
These experiments suggest a functional role for Ack as an early transducer of multiple extracellular stimuli.
These studies suggest that ACK1 senses signal of epidermal growth factor (EGF (show EGF Antibodies)) and regulates ligand-induced degradation of EGFR (show EGFR Antibodies).
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
activated CDC42 kinase 1
, activated Cdc42-associated kinase 1
, activated p21cdc42Hs kinase
, tyrosine kinase non-receptor protein 2
, Cdc42 GTPase-inhibiting protein
, P21cdc42Hs kinase
, non-receptor protein tyrosine kinase ACK
, activated CDC42 kinase 2