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anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) Antibodies

TNK2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. Additionally we are shipping tyrosine Kinase, Non-Receptor, 2 Kits (20) and tyrosine Kinase, Non-Receptor, 2 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TNK2 10188 Q07912
TNK2 51789 O54967
TNK2 303882 Q5U2X5
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Top anti-tyrosine Kinase, Non-Receptor, 2 Antibodies at antibodies-online.com

Showing 10 out of 202 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB ACK1 Antibody (Center Y284) (ABIN657857) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the ACK1 antibody detected the ACK1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from HepG2 cells treated with EGF 200ng/ml 30', using ACK1 (Phospho-Tyr284) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using ACK1 (Phospho-Tyr284) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-Phospho-ACK1-pY518 Antibody (ABIN389970) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-Phospho-ACK1-pY826 Phospho-specific Pab (ABIN650839) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-ACK1 Antibody (C-term) (ABIN392083) in CEM cell line lysates (35 µg/lane). ACK1(arrow) was detected using the purified polyclonal antibody. Western blot analysis of ACK1 (arrow) using rabbit polyclonal ACK1 Antibody (C-term) (ABIN392083). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the ACK1 gene (Lane 2) (60 KD recombinant protein). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of ACK1 Antibody (N-term) (ABIN392082) in K562 cell line lysates (35 µg/lane). ACK1 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of ACK1 (arrow) using rabbit polyclonal ACK1 Antibody (N-term) (ABIN392082). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the ACK1 gene (Lane 2) (60 KD recombinant protein). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of ACK1 (arrow) using rabbit polyclonal ACK1 Antibody (Center) (ABIN392084). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the ACK1 gene (Lane 2) (60 KD recombinant protein). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details

TNK2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-tyrosine Kinase, Non-Receptor, 2 Antibodies

  1. Human Polyclonal TNK2 Primary Antibody for DB - ABIN650839 : Huang, Mukasa, Bonavia, Flynn, Brewer, Cavenee, Furnari, White: Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
    Show all 3 references for ABIN650839

  2. Human Polyclonal TNK2 Primary Antibody for DB - ABIN389970 : Wolf-Yadlin, Hautaniemi, Lauffenburger, White: Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
    Show all 3 references for ABIN389970

  3. Human Polyclonal TNK2 Primary Antibody for WB - ABIN657857 : Mahajan, Mahajan: Shepherding AKT and androgen receptor by Ack1 tyrosine kinase. in Journal of cellular physiology 2010 (PubMed)
    Show all 3 references for ABIN657857

  4. Human Polyclonal TNK2 Primary Antibody for WB - ABIN392084 : Yokoyama, Miller: Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for ABIN392084

  5. Human Polyclonal TNK2 Primary Antibody for EIA, IHC (p) - ABIN359970 : Manser, Leung, Salihuddin, Tan, Lim: A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. in Nature 1993 (PubMed)
    Show all 2 references for ABIN359970

More Antibodies against tyrosine Kinase, Non-Receptor, 2 Interaction Partners

Human tyrosine Kinase, Non-Receptor, 2 (TNK2) interaction partners

  1. Ack1 overexpression promotes metastasis in hepatocellular carcinoma.

  2. Results found that the expression of ACK1 was significantly up-regulated in non-small-cell lung cancer (NSCLC) samples and demonstrate that ACK1 played an oncogenic role in the progression of NSCLC.

  3. Authors identified tyrosine kinase (show TXK Antibodies) nonreceptor 2 (TNK2) point mutations that exhibited oncogenic capacity.

  4. that the cdc42 (show CDC42 Antibodies)-activated, nonreceptor tyrosine kinase (show TXK Antibodies), Ack1, is a DAT (show SLC6A3 Antibodies) endocytic brake that stabilizes DAT (show SLC6A3 Antibodies) at the plasma membrane.

  5. TNK2 (and TNR (show TNR Antibodies)) harbored rare, genetic variants in individuals with familial Parkinson's Disease.

  6. Our results indicate that ACK1 is an independent prognostic marker and promotes hepatocellular carcinoma progression

  7. Studies indicate that activated CDC42 kinase 1 (ACK1) interacts with the estrogen receptor (ER (show ESR1 Antibodies)) and regulates the activity of androgen receptor (AR (show AR Antibodies)) to promote the growth of breast cancer and prostate cancer.

  8. expression of Ack1 plays an important role as predictor of recurrence and poor outcome in hepatocellular carcinoma patients.

  9. ACK1 promotes EMT, migration, and invasion by activating AKT-POU2F1-ECD signalling in Gastric cancer cells. ACK1 may be employed as a new prognostic factor and therapeutic target for gastric cancer.

  10. We uncovered ten new mutations in TNK2 and DDR1 (show DDR1 Antibodies) within serous and endometrioid ECs, thus providing novel insights into the mutation spectrum of each gene in EC.

Mouse (Murine) tyrosine Kinase, Non-Receptor, 2 (TNK2) interaction partners

  1. that the cdc42 (show CDC42 Antibodies)-activated, nonreceptor tyrosine kinase (show TYRO3 Antibodies), Ack1, is a DAT (show SLC6A3 Antibodies) endocytic brake that stabilizes DAT (show SLC6A3 Antibodies) at the plasma membrane.

  2. ACK1 directly binds and phosphorylates the Arp2 (show AICDA Antibodies)/3 regulatory protein (show TGFB1 Antibodies) cortactin (show CTTN Antibodies), potentially providing a direct link to Arp2 (show AICDA Antibodies)/3-based actin dynamics during EGFR (show EGFR Antibodies) degradation.

  3. Ack1-mediated androgen receptor (show AR Antibodies) phosphorylation modulates radiation resistance in castration-resistant prostate cancer

  4. Ack1 mediated AKT/PKB (show AKT1 Antibodies) tyrosine 176 phosphorylation regulates its activation

  5. Ack1/Pyk1 tyrosine kinase (show TYRO3 Antibodies) may be involved both in adult synaptic function and plasticity and in brain development.

  6. Ack1 is up-regulated during development and is expressed in proliferative areas and in migratory pathways in the developing brain.

  7. These experiments suggest a functional role for Ack as an early transducer of multiple extracellular stimuli.

  8. These studies suggest that ACK1 senses signal of epidermal growth factor (EGF (show EGF Antibodies)) and regulates ligand-induced degradation of EGFR (show EGFR Antibodies).

tyrosine Kinase, Non-Receptor, 2 (TNK2) Antigen Profile

Protein Summary

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Gene names and symbols associated with TNK2

  • tyrosine kinase, non-receptor, 2 (TNK2) antibody
  • tyrosine kinase, non-receptor, 2 (Tnk2) antibody
  • tyrosine kinase, non-receptor, 2 (LOC100350340) antibody
  • Ack antibody
  • ACK-1 antibody
  • ACK1 antibody
  • AW552477 antibody
  • Cdgip antibody
  • p21cdc42Hs antibody
  • Pyk1 antibody

Protein level used designations for TNK2

activated CDC42 kinase 1 , activated Cdc42-associated kinase 1 , activated p21cdc42Hs kinase , tyrosine kinase non-receptor protein 2 , ACK-1 , Cdc42 GTPase-inhibiting protein , P21cdc42Hs kinase , non-receptor protein tyrosine kinase ACK , activated CDC42 kinase 2

GENE ID SPECIES
10188 Homo sapiens
51789 Mus musculus
303882 Rattus norvegicus
100513310 Sus scrofa
280710 Bos taurus
431014 Gallus gallus
100350340 Oryctolagus cuniculus
100715920 Cavia porcellus
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