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TNK2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. Additionally we are shipping tyrosine Kinase, Non-Receptor, 2 Antibodies (201) and tyrosine Kinase, Non-Receptor, 2 Kits (20) and many more products for this protein.
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Ack1 overexpression promotes metastasis in hepatocellular carcinoma.
Results found that the expression of ACK1 was significantly up-regulated in non-small-cell lung cancer (NSCLC) samples and demonstrate that ACK1 played an oncogenic role in the progression of NSCLC.
Authors identified tyrosine kinase (show TXK Proteins) nonreceptor 2 (TNK2) point mutations that exhibited oncogenic capacity.
that the cdc42 (show CDC42 Proteins)-activated, nonreceptor tyrosine kinase (show TXK Proteins), Ack1, is a DAT (show SLC6A3 Proteins) endocytic brake that stabilizes DAT (show SLC6A3 Proteins) at the plasma membrane.
TNK2 (and TNR (show TNR Proteins)) harbored rare, genetic variants in individuals with familial Parkinson's Disease.
Our results indicate that ACK1 is an independent prognostic marker and promotes hepatocellular carcinoma progression
Studies indicate that activated CDC42 kinase 1 (ACK1) interacts with the estrogen receptor (ER (show ESR1 Proteins)) and regulates the activity of androgen receptor (AR (show AR Proteins)) to promote the growth of breast cancer and prostate cancer.
expression of Ack1 plays an important role as predictor of recurrence and poor outcome in hepatocellular carcinoma patients.
ACK1 promotes EMT, migration, and invasion by activating AKT-POU2F1-ECD signalling in Gastric cancer cells. ACK1 may be employed as a new prognostic factor and therapeutic target for gastric cancer.
We uncovered ten new mutations in TNK2 and DDR1 (show DDR1 Proteins) within serous and endometrioid ECs, thus providing novel insights into the mutation spectrum of each gene in EC.
that the cdc42 (show CDC42 Proteins)-activated, nonreceptor tyrosine kinase (show TYRO3 Proteins), Ack1, is a DAT (show SLC6A3 Proteins) endocytic brake that stabilizes DAT (show SLC6A3 Proteins) at the plasma membrane.
ACK1 directly binds and phosphorylates the Arp2 (show AICDA Proteins)/3 regulatory protein (show TGFB1 Proteins) cortactin (show CTTN Proteins), potentially providing a direct link to Arp2 (show AICDA Proteins)/3-based actin dynamics during EGFR (show EGFR Proteins) degradation.
Ack1-mediated androgen receptor (show AR Proteins) phosphorylation modulates radiation resistance in castration-resistant prostate cancer
Ack1 mediated AKT/PKB (show AKT1 Proteins) tyrosine 176 phosphorylation regulates its activation
Ack1/Pyk1 tyrosine kinase (show TYRO3 Proteins) may be involved both in adult synaptic function and plasticity and in brain development.
Ack1 is up-regulated during development and is expressed in proliferative areas and in migratory pathways in the developing brain.
These experiments suggest a functional role for Ack as an early transducer of multiple extracellular stimuli.
These studies suggest that ACK1 senses signal of epidermal growth factor (EGF (show EGF Proteins)) and regulates ligand-induced degradation of EGFR (show EGFR Proteins).
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
activated CDC42 kinase 1
, activated Cdc42-associated kinase 1
, activated p21cdc42Hs kinase
, tyrosine kinase non-receptor protein 2
, Cdc42 GTPase-inhibiting protein
, P21cdc42Hs kinase
, non-receptor protein tyrosine kinase ACK
, activated CDC42 kinase 2