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TDP2 encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. Additionally we are shipping TDP2 Proteins (12) and many more products for this protein.
Showing 10 out of 84 products:
Human Polyclonal TDP2 Primary Antibody for EIA, FACS - ABIN955389
Wang, Xu, Zhou, Tian, Xue, Chen, Jia: PhiC31 integrase interacts with TTRAP and inhibits NFkappaB activation. in Molecular biology reports 2010
Show all 2 references for ABIN955389
Human Polyclonal TDP2 Primary Antibody for FACS, IF - ABIN655180
Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: An approach based on a genome-wide association study reveals candidate loci for narcolepsy. in Human genetics 2010
Show all 2 references for ABIN655180
Chicken Polyclonal TDP2 Primary Antibody for IHC, WB - ABIN2777707
Pei, Yordy, Leng, Zhao, Watson, Li: EAPII interacts with ETS1 and modulates its transcriptional function. in Oncogene 2003
Show all 2 references for ABIN2777707
Human Polyclonal TDP2 Primary Antibody for ICC, IF - ABIN4309668
Virgen-Slane, Rozovics, Fitzgerald, Ngo, Chou, van der Heden van Noort, Filippov, Gershon, Semler: An RNA virus hijacks an incognito function of a DNA repair enzyme. in Proceedings of the National Academy of Sciences of the United States of America 2012
Human Polyclonal TDP2 Primary Antibody for IF, WB - ABIN526818
Thomson, Watson, Caldecott, Denneny, Depledge, Hamilton, Hopkins, Jordan, Morrow, Raoof, Waddell, Ogilvie: Generation of assays and antibodies to facilitate the study of human 5'-tyrosyl DNA phosphodiesterase. in Analytical biochemistry 2013
Study revealed a post-translational regulation of TDP2 activity and discovered a new role of ERK3 (show MAPK4 Antibodies) in increasing cancer cells' DNA damage response and chemoresistance to Top2 (show TOP2A Antibodies) inhibitors.
Data show that DNA-repair enzyme (show LIG4 Antibodies) TDP2 knockdown in HepG2 cells significantly delays the conversion of relaxed circular DNA (RC-DNA) to covalently closed circular (ccc) DNA.
This article summarizes and compares the biochemistry, functions, and post-translational regulation of TDP1 (show TDP1 Antibodies) and TDP2, as well as the relevance of TDP1 (show TDP1 Antibodies) and TDP2 as determinants of response to anticancer agents
Proteolytic degradation of Top2 (show TOP2A Antibodies) enables the processing of Top2 (show TOP2A Antibodies).DNA and Top2 (show TOP2A Antibodies).RNA covalent complexes by TDP2.
TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.
Mutations in the 5'-tyrosyl-DNA phosphodiesterase activity of TTRAP,in particular TTRAP(E152A), showed decreased inhibitory activity on cell growth.
Magnesium is indispensable for a 5'-tyrosyl DNA phosphodiesterase activity.
VPg unlinkase activity in different mammalian cell lines correlates with their differential expression of TDP2.
Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2 (show MUC7 Antibodies)+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes.
findings suggest a previously unidentified function for TTRAP and nucleolar cavities in ribosome biogenesis under stress.
data show that TDP2 activity potentiates enterovirus infections and, in the case of coxsackievirus B3, is a required host function following virus infection of mouse cells
our data reveal TDP2-mediated error-free NHEJ as an efficient and accurate mechanism to repair TOP2 (show TOP2 Antibodies)-induced DSBs
Evidence implicates Tdp2 in the repair of Top1 (show TOP1 Antibodies)-mediated DNA damage in cultured cells and in vivo, in the absence of Tdp1 (show TDP1 Antibodies).
the protein associates with TGF-beta (show TGFB1 Antibodies) receptors and components of the TRAF6 (show TRAF6 Antibodies)-TAK1 (show NR2C2 Antibodies) signaling module
although the role of Smad (show SMAD1 Antibodies) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap provides insight into a novel Smad (show SMAD1 Antibodies) partner that plays an essential role in the fine-tuning of this signal transduction cascade
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.
, 5'-tyrosyl-DNA phosphodiesterase
, ETS1-associated protein 2
, ETS1-associated protein II
, TRAF and TNF receptor associated protein
, TRAF and TNF receptor-associated protein
, VPg unlinkase
, tyr-DNA phosphodiesterase 2
, tyrosyl-RNA phosphodiesterase
, TRAF and TNF receptor-associated protein homolog
, Tyr-DNA phosphodiesterase 2
, Traf and Tnf receptor associated protein
, immune transcriptional repressor
, traf and tnf receptor associated protein, like
, tyrosyl-DNA phosphodiesterase 2