tyrosyl-DNA phosphodiesterase 2 (TDP2) ELISA Kits

TDP2 encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. Additionally we are shipping TDP2 Antibodies (88) and TDP2 Proteins (12) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human TDP2 TDP2 51567 O95551
Anti-Mouse TDP2 TDP2 56196 Q9JJX7
Anti-Rat TDP2 TDP2 498749 Q3T1H5
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More ELISA Kits for TDP2 Interaction Partners

Human tyrosyl-DNA phosphodiesterase 2 (TDP2) interaction partners

  1. Both the genome instability and cell death of MRE11 (show MRE11A ELISA Kits)-null and MRE11 (show MRE11A ELISA Kits)-mutated H129N cells are significantly reversed by overexpression of Tdp2, an enzyme that eliminates covalent Top2 (show TOP2A ELISA Kits) conjugates; thus, the essential role of Mre11 (show MRE11A ELISA Kits) nuclease (show DCLRE1C ELISA Kits) activity is likely to remove the DNA lesions.

  2. Study revealed a post-translational regulation of TDP2 activity and discovered a new role of ERK3 (show MAPK4 ELISA Kits) in increasing cancer cells' DNA damage response and chemoresistance to Top2 (show TOP2A ELISA Kits) inhibitors.

  3. Data show that DNA-repair enzyme (show LIG4 ELISA Kits) TDP2 knockdown in HepG2 cells significantly delays the conversion of relaxed circular DNA (RC-DNA) to covalently closed circular (ccc) DNA.

  4. This article summarizes and compares the biochemistry, functions, and post-translational regulation of TDP1 (show TDP1 ELISA Kits) and TDP2, as well as the relevance of TDP1 (show TDP1 ELISA Kits) and TDP2 as determinants of response to anticancer agents

  5. Proteolytic degradation of Top2 (show TOP2A ELISA Kits) enables the processing of Top2 (show TOP2A ELISA Kits).DNA and Top2 (show TOP2A ELISA Kits).RNA covalent complexes by TDP2.

  6. TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.

  7. Mutations in the 5'-tyrosyl-DNA phosphodiesterase activity of TTRAP,in particular TTRAP(E152A), showed decreased inhibitory activity on cell growth.

  8. Magnesium is indispensable for a 5'-tyrosyl DNA phosphodiesterase activity.

  9. VPg unlinkase activity in different mammalian cell lines correlates with their differential expression of TDP2.

  10. Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2 (show MUC7 ELISA Kits)+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes.

Mouse (Murine) tyrosyl-DNA phosphodiesterase 2 (TDP2) interaction partners

  1. The results collectively provide a structural mechanism for Tdp2 engagement of heterogeneous DNA damage that causes Top2 (show TOP2 ELISA Kits) poisoning.

  2. data show that TDP2 activity potentiates enterovirus infections and, in the case of coxsackievirus B3, is a required host function following virus infection of mouse cells

  3. our data reveal TDP2-mediated error-free NHEJ as an efficient and accurate mechanism to repair TOP2 (show TOP2 ELISA Kits)-induced DSBs

  4. Evidence implicates Tdp2 in the repair of Top1 (show TOP1 ELISA Kits)-mediated DNA damage in cultured cells and in vivo, in the absence of Tdp1 (show TDP1 ELISA Kits).

  5. the protein associates with TGF-beta (show TGFB1 ELISA Kits) receptors and components of the TRAF6 (show TRAF6 ELISA Kits)-TAK1 (show NR2C2 ELISA Kits) signaling module

Zebrafish tyrosyl-DNA phosphodiesterase 2 (TDP2) interaction partners

  1. although the role of Smad (show SMAD1 ELISA Kits) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap provides insight into a novel Smad (show SMAD1 ELISA Kits) partner that plays an essential role in the fine-tuning of this signal transduction cascade

TDP2 Antigen Profile

Antigen Summary

This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.

Gene names and symbols associated with TDP2

  • tyrosyl-DNA phosphodiesterase 2 (TDP2) antibody
  • tyrosyl-DNA phosphodiesterase 2 (tdp2) antibody
  • tyrosyl-DNA phosphodiesterase 2 (Tdp2) antibody
  • tyrosyl-DNA phosphodiesterase 2b (tdp2b) antibody
  • ad022 antibody
  • D13Ertd656e antibody
  • dJ30M3.3 antibody
  • eap2 antibody
  • EAPII antibody
  • hTDP2 antibody
  • tdp2 antibody
  • Ttrap antibody
  • ttrapl antibody

Protein level used designations for TDP2

5'-Tyr-DNA phosphodiesterase , 5'-tyrosyl-DNA phosphodiesterase , ETS1-associated protein 2 , ETS1-associated protein II , TRAF and TNF receptor associated protein , TRAF and TNF receptor-associated protein , VPg unlinkase , tyr-DNA phosphodiesterase 2 , tyrosyl-RNA phosphodiesterase , TRAF and TNF receptor-associated protein homolog , Tyr-DNA phosphodiesterase 2 , Traf and Tnf receptor associated protein , immune transcriptional repressor , traf and tnf receptor associated protein, like , tyrosyl-DNA phosphodiesterase 2

51567 Homo sapiens
100049743 Xenopus laevis
421007 Gallus gallus
507579 Bos taurus
56196 Mus musculus
498749 Rattus norvegicus
553516 Danio rerio
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