Apicidin
1 image
-
- Application
- Blocking Antibody (Inhibition)
- Characteristics
-
Potent HDAC Inhibitor
Blocks Cell Cycle G1
HIV-1 Promoter
-
-
- Restrictions
- For Research Use only
-
- Storage
- -20 °C
-
- Background
- Potent inhibitor of histone deacetylase (HDAC) activity and proliferation. Induces cell cycle arrest at the G1 phase. At 100 nM it induces a long lasting hyperacetylation of histone H4 while that induced by trichostatin is transient. Stimulates apoptosis. Apoptosis is induced via induction of Fas/Fas ligand. Displays potent antiangiogenic effects and dramatically decreases HIF-1a protein levels and transcriptional activity in human and mouse tumor cell lines. Apicidin is a fungal toxin that has broad spectrum activity against Apicomplexan parasites.
- CAS-No
- 183506-66-3
-
You are here:
