omega-conotoxin MVIIC (omega contoxin MVIIC)

Catalog No. ABIN1540045

Product Details

Target: Conotoxin MVIIC omega

Application: Blocking Reagent (BR)

Purpose: omega-conotoxin MVIIC is a calcium channel blocker

Sequence: Cys1-Lys-Gly-Lys-Gly-Ala-Pro-Cys8-Arg-Lys-Thr-Met-Tyr-Asp-Cys15-Cys16-Ser-Gly-Ser-Cys20-Gly-Arg-Arg-Gly-Lys-Cys26-NH2Disulfide bonds between Cys1-Cys16, Cys8-Cys20and Cys15-Cys26

Application Details

Restrictions: For Research Use only

Handling

Target Details

Target: Conotoxin MVIIC omega

Background: Omega-conotoxin MVIIC has been isolated from the venom of the cone Conus magus. omega-conotoxin MVIIC inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of omega-conotoxin GVIA-resistant currents in hippocampal CA1 neurons. omega-conotoxin MVIIC also presents an inhibition of omega-conotoxin GVIA-resistant depolarization-induced neurotransmitter release in cerebellar neurons of rats.

Molecular Weight: 2750.2 Da

CAS-No: 147794-23-8