omega-conotoxin GVIA
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- Target
- omega-conotoxin GVIA
- Application
- Blocking Reagent (BR)
- Purpose
- omega-conotoxin GVIA blocks Cav2.2
- Sequence
- H-Cys1-Lys-Ser-Hyp-Gly-Ser-Ser-Cys8-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys15-Cys16-Arg-Ser-Cys19-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys26-Tyr-NH2Hyp: hydroxypro line(Disulfide bonds between Cys1-Cys16, Cys8-Cys19 and Cys15-Cys26)
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- Restrictions
- For Research Use only
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- Target
- omega-conotoxin GVIA
- Background
- Omega-conotoxin GVIA has been isolated from the venom of the cone Conus eographus. Omega-conotoxin GVIA acts at presynaptic membranes. It binds and blocks specifically Cav2.2 channel with an ED50 of 68pM.
- Molecular Weight
- 3036.05 Da
- CAS-No
- 106375-28-4
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