Iberiotoxin (IbTx)
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- Target
- Iberiotoxin / IbTX
- Application
- Blocking Reagent (BR)
- Purpose
- Iberiotoxin (IbTx) is a Kca channel inhibitor
- Sequence
- pGlu-Phe-Thr-AspVal-Asp-Cys-Ser-Val-Ser-Lys-GIu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-GIn-OHDisulfid e bridges: Cys7-Cys28, Cys13-Cys33, Cys17-Cys35
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- Restrictions
- For Research Use only
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- Target
- Iberiotoxin / IbTX
- Background
- Iberiotoxin (IbTx) is a toxin that was originally isolated from Buthus tamulus scorpion venom. Iberiotoxin inhibits selectively the high conductance Ca2+-activated K+ channel (KCa1.1). This toxin does not affect other types of voltage-dependent K+ channels which are sensitive to the Charybdotoxin. Iberiotoxin is a valuable tool to study specifically Maxi-K channels.
- Molecular Weight
- 4230.8 Da
- CAS-No
- 129203-60-7
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