IRDye 800CW 2-DG Optical Probe

Details for Product No. ABIN2169594, Supplier: Log in to see
Target Name (Antigen)
Host
Synthetic
Conjugate
IRDye800CW
Application
BioImaging (BI)
Options
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Brand BrightSite™
Specificity Tumor cells
Characteristics 2-deoxyglucose (2-DG) is a glucose analog that utilizes the GLUT transporters for entry into the cell. Upon phosphorylation, it is not metabolized further and is effectively trapped within the cell. A well-established characteristic of many cancer cells is an elevated rate of metabolism, in particular, glucos uptake. IRDye 800CW 2-DG has been shown to bind tumor cells in both in vitro assays and in vivo animal studies for multiple tumor types, including: A431, SW620, MDA-MB-231, SKBr3, U87, PC3M-LN4, and 22Rv1.
glucose analog
Optical Probe
Upon receipt, store at -20 °C prior to reconstitution. After reconstitution, store at 4 °C. Reconstituted material should be used within 2 weeks. Protect from light.
Purification 0.2 μm nylon membrane
Application Notes in vivo: 10-20 nmole per mouse (25 grams)
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute with 1 mL sterile 1X PBS
Concentration 0.1 nM/μL
Buffer PBS
Handling Advice Protect from light.
Storage -20 °C
Supplier Images
Immunofluorescence (IF) image for IRDye 800CW 2-DG Optical Probe (ABIN2169594) IRDye 800CW 2-DG Optical Probe
Product cited in: Keereweer, Kerrebijn, van Driel, Xie, Kaijzel, Snoeks, Que, Hutteman, van der Vorst, Mieog, Vahrmeijer, van de Velde, Baatenburg de Jong, Löwik: "Optical image-guided surgery--where do we stand?" in: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, Vol. 13, Issue 2, pp. 199-207, 2011 (PubMed).