IRDye 800CW BoneTag Optical Probe

Details for Product No. ABIN2169596, Supplier: Log in to see
Host
Synthetic
Conjugate
IRDye800CW
Application
BioImaging (BI)
Options
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Brand BrightSite™,BoneTag™
Specificity Bone
Characteristics Calcium-chelating compounds have been used effectively for the detection of bone mineralization, growth, and morphological changes, including tetracycline derivatives, xylenol orange, alizarin, calcein, and fluorescein. These characteristics have been used to produce a near infrared (NIR) optical bone marker for small animal imaging. Using MC3T3-E1 (osteoblasts) in in vitro cell-based assays, the IRDye BoneTag shows specific binding characteristics. In vivo testing of IRDye BoneTag optical probes are effective for skeletal labeling for imaging, which is unabated several weeks post-administration.
calcium-chelating compound
Optical Probe
Upon receipt, store at -20 °C prior to reconstitution. Reconstituted product should be used immediately.
Purification 0.2 μm nylon membrane
Application Notes in vivo: 2 nmol per mouse (25 grams)
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute with 0.5 mL sterile 1X PBS
Concentration 0.02 nM/μL
Buffer PBS
Handling Advice Protect from light.
Storage -20 °C
Supplier Images
Immunofluorescence (IF) image for IRDye 800CW BoneTag Optical Probe (ABIN2169596) IRDye 800CW BoneTag Optical Probe
Product cited in: Kovar, Xu, Draney, Cupp, Simpson, Olive: "Near-infrared-labeled tetracycline derivative is an effective marker of bone deposition in mice." in: Analytical biochemistry, Vol. 416, Issue 2, pp. 167-73, 2011 (PubMed).