Details for Product No. ABIN412073
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Functional Studies (Func), Cell Culture (CC)
Pubmed 8 references available
Quantity 5 mg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Sequence Z-Tyr-Val-Ala-Asp(OMe)-FMK
Characteristics A synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Purity Single spot by TLC
Molecular Weight 630.7 Da
Application Notes We recommend using 2-10 µM for inhibiting caspase activity in cell culture.
The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Lyophilized
Handling Advice Protect from light and moisture.
Storage -20 °C
Expiry Date 12 months
Product cited in: Burm, Zuiderwijk-Sick, t Jong et al.: "Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 2, pp. 678-87, 2015 (PubMed).

Kim, Amarnani, Gnanaguru et al.: "Tamoxifen toxicity in cultured retinal pigment epithelial cells is mediated by concurrent regulated cell death mechanisms." in: Investigative ophthalmology & visual science, Vol. 55, Issue 8, pp. 4747-58, 2014 (PubMed).

Tseng, Thein, Kinnunen et al.: "NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration." in: Investigative ophthalmology & visual science, Vol. 54, Issue 1, pp. 110-20, 2013 (PubMed).

Lee, Hwang, Palaniyar et al.: "Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection." in: PLoS ONE, Vol. 7, Issue 4, pp. e35812, 2012 (PubMed).

Ariazi, Cunliffe, Lewis-Wambi et al.: "Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 47, pp. 18879-86, 2011 (PubMed).

Chang, Lin, Wu et al.: "Mechanisms underlying benzyl alcohol cytotoxicity (triamcinolone acetonide preservative) in human retinal pigment epithelial cells." in: Investigative ophthalmology & visual science, Vol. 52, Issue 7, pp. 4214-22, 2011 (PubMed).

Wei, Kadia, Tong et al.: "The combination of a histone deacetylase inhibitor with the Bcl-2 homology domain-3 mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 15, pp. 3923-32, 2010 (PubMed).

Shao: "Understanding the mechanisms of human tubal ectopic pregnancies: new evidence from knockout mouse models." in: Human reproduction (Oxford, England), Vol. 25, Issue 3, pp. 584-7, 2010 (PubMed).

Catalog No. ABIN412073
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