Z-VDVAD-FMK

Details for Product No. ABIN412074
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Application
Functional Studies (Func), Cell Culture (CC)
Pubmed 5 references available
Catalog no. ABIN412074
Quantity 1 mg
Price
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Sequence Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK
Characteristics A synthetic peptide that irreversibly inhibits activity of caspase-2. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Purity Single spot by TLC
Molecular Weight 695.7 Da
Application Notes We recommend using 2-10 µM for inhibiting caspase activity in cell culture.
The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Lyophilized
Handling Advice Protect from light and moisture.
Storage -20 °C
Expiry Date 12 months
Product cited in: Upton, Austgen, Nishino et al.: "Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress." in: Molecular and cellular biology, Vol. 28, Issue 12, pp. 3943-51, 2008 (PubMed).

Höglund, Nilsson, Forshell et al.: "Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine." in: Blood, Vol. 113, Issue 18, pp. 4281-8, 2009 (PubMed).

Nakajima, Nishimura, Nakaima et al.: "Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 30, pp. 12448-52, 2009 (PubMed).

Chang, Lin, Wu et al.: "Mechanisms underlying benzyl alcohol cytotoxicity (triamcinolone acetonide preservative) in human retinal pigment epithelial cells." in: Investigative ophthalmology & visual science, Vol. 52, Issue 7, pp. 4214-22, 2011 (PubMed).

Ariazi, Cunliffe, Lewis-Wambi et al.: "Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 47, pp. 18879-86, 2011 (PubMed).

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