Did you know that you can buy products from over 140 different suppliers from us?

Z-DEVD-FMK

Details for Product No. ABIN412077
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Application
Functional Studies (Func), Cell Culture (CC)
Pubmed 9 references available
Quantity 5 mg
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN412077
764.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Sequence Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK
Characteristics A synthetic peptide that irreversibly inhibits activity of DEVD-dependent caspases (e.g., caspase-3 and caspase-7) and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Purity Single spot by TLC
Molecular Weight 668.7 Da
Application Notes We recommend using 2-10 µM for inhibiting caspase activity in cell culture.
The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Lyophilized
Handling Advice Protect from light and moisture.
Storage -20 °C
Expiry Date 12 months
Product cited in: Cunningham, Giuffrida, Roberts: "Androgens induce dopaminergic neurotoxicity via caspase-3-dependent activation of protein kinase Cdelta." in: Endocrinology, Vol. 150, Issue 12, pp. 5539-48, 2009 (PubMed).

Du, Yamamoto, Ueda et al.: "Activated protein C rescues the retina from ischemia-induced cell death." in: Investigative ophthalmology & visual science, Vol. 52, Issue 2, pp. 987-93, 2011 (PubMed).

Abdul-Ghani, Dufort, Stiles et al.: "Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals." in: Molecular and cellular biology, Vol. 31, Issue 1, pp. 163-78, 2010 (PubMed).

Zhong, Carney, Boyan et al.: "17β-Estradiol regulates rat growth plate chondrocyte apoptosis through a mitochondrial pathway not involving nitric oxide or MAPKs." in: Endocrinology, Vol. 152, Issue 1, pp. 82-92, 2010 (PubMed).

Hara, Senga, Biswas et al.: "Recovery of anoikis in Src-transformed cells and human breast carcinoma cells by restoration of the SIRP α1/SHP-2 signaling system." in: Cancer research, Vol. 71, Issue 4, pp. 1229-34, 2011 (PubMed).

Verma, Jain, Caseltine et al.: "TCR mimic monoclonal antibodies induce apoptosis of tumor cells via immune effector-independent mechanisms." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 5, pp. 3265-76, 2011 (PubMed).

Vogt, Harmata, Coulombe et al.: "Causes and consequences of stolon regression in a colonial hydroid." in: The Journal of experimental biology, Vol. 214, Issue Pt 19, pp. 3197-205, 2011 (PubMed).

Ariazi, Cunliffe, Lewis-Wambi et al.: "Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 47, pp. 18879-86, 2011 (PubMed).

Heinhuis, Koenders, van den Berg et al.: "Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5733-43, 2012 (PubMed).

Validation Images
back to top