Z-LEVD-FMK

Details for Product No. ABIN412079
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Application
Functional Studies (Func), Cell Culture (CC)
Pubmed 5 references available
Quantity 5 mg
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Catalog No. ABIN412079
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Sequence Z-Leu-Glu(OMe)-Val-Asp(OMe)-FMK
Characteristics A synthetic peptide that irreversibly inhibits activity of LEVD-dependent caspases (e.g., caspase-4). The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Purity Single spot by TLC
Molecular Weight 652.7 Da
Application Notes We recommend using 2-10 µM for inhibiting caspase activity in cell culture.
The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Lyophilized
Handling Advice Protect from light and moisture.
Storage -20 °C
Expiry Date 12 months
Product cited in: Akamatsu, Shibata, Ito et al.: "Riluzole induces apoptotic cell death in human prostate cancer cells via endoplasmic reticulum stress." in: Anticancer research, Vol. 29, Issue 6, pp. 2195-204, 2009 (PubMed).

Binet, Chiasson, Girard: "Interaction between arsenic trioxide (ATO) and human neutrophils." in: Human & experimental toxicology, Vol. 30, Issue 5, pp. 416-24, 2011 (PubMed).

Wei, Kadia, Tong et al.: "The combination of a histone deacetylase inhibitor with the Bcl-2 homology domain-3 mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 15, pp. 3923-32, 2010 (PubMed).

Rosati, Sabatini, Rampino et al.: "Novel targets for endoplasmic reticulum stress-induced apoptosis in B-CLL." in: Blood, Vol. 116, Issue 15, pp. 2713-23, 2010 (PubMed).

Ariazi, Cunliffe, Lewis-Wambi et al.: "Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 47, pp. 18879-86, 2011 (PubMed).

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