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Details for Product No. ABIN412082

Z-IETD-FMK

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Application
Functional Studies (Func), Cell Culture (CC)
Pubmed 6 references available
Catalog no. ABIN412082
Quantity 1 mg
Price
258.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Sequence Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK
Characteristics A synthetic peptide that irreversibly inhibits FLICE and related protease/caspase activity and blocks apoptosis. IETD is the specific recognition sequence found in CPP32 proenzyme. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups.)
Purity Single spot by TLC
Molecular Weight 654.7 Da
Application Notes We recommend using 2-10 µM for inhibiting caspase activity in cell culture.
The optimal doses may vary among different cells and culture conditions.
Restrictions For Research Use only
Format Lyophilized
Handling Advice Protect from light and moisture.
Storage -20 °C
Expiry Date 12 months
Product cited in: Tang, Liu, Wang et al.: "Involvement of caspase 8 in apoptosis induced by ultrasound-activated hematoporphyrin in sarcoma 180 cells in vitro." in: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, Vol. 27, Issue 4, pp. 645-56, 2008 (PubMed).

Du, Yamamoto, Ueda et al.: "Activated protein C rescues the retina from ischemia-induced cell death." in: Investigative ophthalmology & visual science, Vol. 52, Issue 2, pp. 987-93, 2011 (PubMed).

Abdul-Ghani, Dufort, Stiles et al.: "Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals." in: Molecular and cellular biology, Vol. 31, Issue 1, pp. 163-78, 2010 (PubMed).

Saha, Jiang, Mukai et al.: "RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses." in: Molecular cancer therapeutics, Vol. 9, Issue 11, pp. 3041-51, 2010 (PubMed).

Hara, Senga, Biswas et al.: "Recovery of anoikis in Src-transformed cells and human breast carcinoma cells by restoration of the SIRP α1/SHP-2 signaling system." in: Cancer research, Vol. 71, Issue 4, pp. 1229-34, 2011 (PubMed).

Ariazi, Cunliffe, Lewis-Wambi et al.: "Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 47, pp. 18879-86, 2011 (PubMed).

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