Z-LEHD-FMK

Details for Product No. ABIN412085
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Application
Functional Studies (Func), Cell Culture (CC)
Pubmed 8 references available
Quantity 5 mg
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Catalog No. ABIN412085
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Sequence Z-Leu-Glu(OMe)-His-Asp(OMe)-FMK.TFA
Characteristics A synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Purity Single spot by TLC
Molecular Weight 690.71 Da
Application Notes We recommend using 2-10 µM for inhibiting caspase activity in cell culture.
The optimal doses may vary for different cells and culture conditions.
Note: For research purpose only! Not to be used in humans.
Restrictions For Research Use only
Format Lyophilized
Handling Advice Protect from light and moisture.
Storage -20 °C
Expiry Date 12 months
Product cited in: Jin, Ojcius, Sun et al.: "Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways." in: Infection and immunity, Vol. 77, Issue 2, pp. 799-809, 2009 (PubMed).

Bian, Elner, Elner: "Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells." in: Investigative ophthalmology & visual science, Vol. 50, Issue 12, pp. 6006-14, 2009 (PubMed).

Lipke, Matute-Bello, Herrero et al.: "Febrile-range hyperthermia augments lipopolysaccharide-induced lung injury by a mechanism of enhanced alveolar epithelial apoptosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 7, pp. 3801-13, 2010 (PubMed).

Du, Yamamoto, Ueda et al.: "Activated protein C rescues the retina from ischemia-induced cell death." in: Investigative ophthalmology & visual science, Vol. 52, Issue 2, pp. 987-93, 2011 (PubMed).

Hara, Senga, Biswas et al.: "Recovery of anoikis in Src-transformed cells and human breast carcinoma cells by restoration of the SIRP α1/SHP-2 signaling system." in: Cancer research, Vol. 71, Issue 4, pp. 1229-34, 2011 (PubMed).

Verma, Jain, Caseltine et al.: "TCR mimic monoclonal antibodies induce apoptosis of tumor cells via immune effector-independent mechanisms." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 5, pp. 3265-76, 2011 (PubMed).

Xie, Jiang, Wan et al.: "Induction of a 55 kDa acetylcholinesterase protein during apoptosis and its negative regulation by the Akt pathway." in: Journal of molecular cell biology, Vol. 3, Issue 4, pp. 250-9, 2011 (PubMed).

Ariazi, Cunliffe, Lewis-Wambi et al.: "Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 47, pp. 18879-86, 2011 (PubMed).

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