Q-VD-OPH

Application: Functional Studies (Func), Cell Culture (CC)

Catalog no.: ABIN412091

Additional Information

Immunogen: Sequence: Quinolyl-Val-Asp-OPH

Sequence: Quinolyl-Val-Asp-OPh

Format: Lyophilized

Description: A synthetic peptide that is potent, cell permeable, nontoxic and irreversibly inhibits caspase activity to blocks apoptosis. The new generation of caspase inhibitor is more stable in aqueous environment and exhibits several folds higher activity than the corresponding FMK caspase inhibitors. Q-VD-OPH is the inhibitor of choice for both in vitro and in vivo studies.

Characteristics: Molecular formula: C₂₆H₂₅F₂N₃O₆

Molecular Weight: 513.49 Da

Application Details

Application Notes: We recommend using 1-10 μ M concentration for in vitro enzyme kinetics studies. For in vivo usage, quantity needs to be determined by researcher. 20 mg/Kg of body weight is a proper place to start.

Handling Advice: Protect from light and moisture

Purity: >95% by HPLC

Storage: -20°C

Expiry Date: 12 months

Restrictions: For Research Use only

Publications

Product: Höglund, Nilsson, Forshell et al.: "Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine." in: Blood, Vol. 113, Issue 18, pp. 4281-8, 2009 (PubMed).

Yamanouchi, Morgan, Kato et al.: "Effects of caspase inhibitor on angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, Issue 4, pp. 702-7, 2010 (PubMed).

Rana, Gupta, Gomez et al.: "Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 6, pp. 2126-34, 2010 (PubMed).

Novgorodov, Chudakova, Wheeler et al.: "Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 6, pp. 4644-58, 2011 (PubMed).

Höglund, Nilsson, Muralidharan et al.: "Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 22, pp. 7067-79, 2011 (PubMed).

Frisan, Vandekerckhove, de Thonel et al.: "Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes." in: Blood, Vol. 119, Issue 6, pp. 1532-42, 2012 (PubMed).