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Celecoxib

Details for Product No. ABIN412148, Supplier: Log in to see
Application
Cell Culture (CC), Functional Studies (Func)
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Characteristics Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits prostaglandin production. Celecoxib is approximately 7.6-fold more selective for COX-2 inhibition over COX-1.This specificity allows celecoxib to reduce inflammation and pain while minimizing gastrointestinal adverse drug reactions that are common with non-selective non-steroidal anti-inflammatory drugs.
Purity ≥ 99 %
Chemical Name Celebrex, Celebra, Celecox, SC-58635
Formula C₁₇H₁₄F₃N₃O₂S
Permeability Cell-permeable
Molecular Weight 381.37 g/mol
CAS-No 169590-42-5
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and air
Storage -20 °C
Expiry Date 24 months
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 image for Celecoxib (ABIN412148) Celecoxib
Product cited in: Mao, Poschke, Wennerberg, Pico de Coaña, Egyhazi Brage, Schultz, Hansson, Masucci, Lundqvist, Kiessling: "Melanoma-educated CD14+ cells acquire a myeloid-derived suppressor cell phenotype through COX-2-dependent mechanisms." in: Cancer research, Vol. 73, Issue 13, pp. 3877-87, 2013 (PubMed).

Obermajer, Wong, Edwards, Chen, Scott, Khader, Kolls, Odunsi, Billiar, Kalinski: "Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling." in: The Journal of experimental medicine, Vol. 210, Issue 7, pp. 1433-445, 2013 (PubMed).

Fujita, Kohanbash, Fellows-Mayle, Hamilton, Komohara, Decker, Ohlfest, Okada: "COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells." in: Cancer research, Vol. 71, Issue 7, pp. 2664-74, 2011 (PubMed).

Obermajer, Muthuswamy, Lesnock, Edwards, Kalinski: "Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells." in: Blood, Vol. 118, Issue 20, pp. 5498-505, 2011 (PubMed).

Kwon, Lee, So, Chae, Hwang, Sahoo, Nam, Rhee, Hwang, Im: "Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 5, pp. 2159-64, 2010 (PubMed).