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Celecoxib

Details for Product No. ABIN412148, Supplier: Login to see
Application
Cell Culture (CC), Functional Studies (Func)
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Characteristics Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits prostaglandin production. Celecoxib is approximately 7.6-fold more selective for COX-2 inhibition over COX-1.This specificity allows celecoxib to reduce inflammation and pain while minimizing gastrointestinal adverse drug reactions that are common with non-selective non-steroidal anti-inflammatory drugs.
Purity 99,00 %
Molecular Weight 381.37 Da
CAS-No 169590-42-5
Restrictions For Research Use only
Format Solid
Reconstitution Solubility: Soluble in DMSO (200 mg/mL), ethanol (100 mg/mL), Poorly soluble in water.
Handling Advice Protect from light and air.
Storage -20 °C
Expiry Date 24 months
Product cited in: Obermajer, Wong, Edwards et al.: "Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling." in: The Journal of experimental medicine, Vol. 210, Issue 7, pp. 1433-445, 2013 (PubMed).

Mao, Poschke, Wennerberg et al.: "Melanoma-educated CD14+ cells acquire a myeloid-derived suppressor cell phenotype through COX-2-dependent mechanisms." in: Cancer research, Vol. 73, Issue 13, pp. 3877-87, 2013 (PubMed).

Obermajer, Muthuswamy, Lesnock et al.: "Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells." in: Blood, Vol. 118, Issue 20, pp. 5498-505, 2011 (PubMed).

Fujita, Kohanbash, Fellows-Mayle et al.: "COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells." in: Cancer research, Vol. 71, Issue 7, pp. 2664-74, 2011 (PubMed).

Kwon, Lee, So et al.: "Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 5, pp. 2159-64, 2010 (PubMed).