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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Functional Studies (Func), Cell Culture (CC)
|3 references available|
|Price||115.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Description||Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits prostaglandin production. Celecoxib is approximately 7.6-fold more selective for COX-2 inhibition over COX-1. This specificity allows celecoxib to reduce inflammation and pain while minimizing gastrointestinal adverse drug reactions that are common with non-selective non-steroidal anti-inflammatory drugs.|
|Characteristics||Molecular formula: C₁₇H₁₄F₃N₃O₂S|
|Molecular Weight||381.37 Da|
|Handling Advice||Protect from light and air|
|Buffer||Solubility: Soluble in DMSO (200 mg/ml), ethanol (100 mg/ml), Poorly soluble in water.|
|Restrictions||For Research Use only|
Kwon, Lee, So et al.: "Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 5, pp. 2159-64, 2010 (PubMed).
Fujita, Kohanbash, Fellows-Mayle et al.: "COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells." in: Cancer research, Vol. 71, Issue 7, pp. 2664-74, 2011 (PubMed).
Obermajer, Muthuswamy, Lesnock et al.: "Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells." in: Blood, Vol. 118, Issue 20, pp. 5498-505, 2011 (PubMed).