Celecoxib

Application: Functional Studies (Func), Cell Culture (CC)

Catalog no.: ABIN412149

Additional Information

CAS-No: 169590-42-5

Description: Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits prostaglandin production. Celecoxib is approximately 7.6-fold more selective for COX-2 inhibition over COX-1. This specificity allows celecoxib to reduce inflammation and pain while minimizing gastrointestinal adverse drug reactions that are common with non-selective non-steroidal anti-inflammatory drugs.

Characteristics: Molecular formular: C 17 H 14 F 3 N 3 O 2 S

Molecular Weight: 381.37

Application Details

Purity: >99%

Buffer: Solubility: Soluble in DMSO (200 mg/ml), ethanol (100 mg/ml), Poorly soluble in water.

Storage: -20 o C in the dark. Do not expose to sunlight or fluorescent lights for extended periods. CAUTION: Do not ingest, swallow, or inhale. Do not get in eyes or on skin. Care should be taken to prevent contact through all routes of exposure.

Restrictions: For Research Use only

Publications

Product: Kwon, Lee, So et al.: "Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 5, pp. 2159-64, 2010 (PubMed).

Fujita, Kohanbash, Fellows-Mayle et al.: "COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells." in: Cancer research, Vol. 71, Issue 7, pp. 2664-74, 2011 (PubMed).

Obermajer, Muthuswamy, Lesnock et al.: "Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells." in: Blood, Vol. 118, Issue 20, pp. 5498-505, 2011 (PubMed).