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Sodium 4-phenylbutyrate

Details for Product No. ABIN412202, Supplier: Log in to see
Application
Cell Culture (CC), Functional Studies (Func)
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Characteristics Inhibitor of histone deacetylase (HDAC). Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.
Purity ≥ 99 % by HPLC
Chemical Name 4-Phenylbutyric acid, sodium salt, Sodium phenylbutyrate, 4-PB
Formula C₁₀H₁₁O₂ . Na
Permeability Cell-permeable
Molecular Weight 186.2 g/mol
CAS-No 1716-12-7
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 24 months
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Product cited in: Gautherot, Durand-Schneider, Delautier, Delaunay, Rada, Gabillet, Housset, Maurice, Aït-Slimane: "Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4." in: The Journal of biological chemistry, Vol. 287, Issue 7, pp. 5070-8, 2012 (PubMed).

Ma, Liu, El-Achkar, Wu: "Molecular and cellular effects of Tamm-Horsfall protein mutations and their rescue by chemical chaperones." in: The Journal of biological chemistry, Vol. 287, Issue 2, pp. 1290-305, 2012 (PubMed).