Akt Inhibitor

Application: Functional Studies (Func), Cell Culture (CC)

Catalog no.: ABIN412306

Additional Information

Description: Potent inhibitor of Akt (PKB) (IC 50 = 2 µM). Weak inhibitor of phosphatidylinositol 3-kinase (PI3- K) (IC 50 = 83 µM). Has been shown to inhibit the growth of the following cancer cell lines: HeLa (IC 50 = 2.5 µM), HT-29 (IC 50 = 10 µM), MCF-7 (IC 50 = 1.2 µM), and PC-3 (IC 50 = 2.0 µM). REFERENCE: Y. Hu, et al. (2000) J. Med. Chem. 43, 3045.

Characteristics: Molecular formular: C 30 H 58 O 10

Molecular Weight: 578.8

Application Details

Purity: >98%

Buffer: Solubility: Soluble in DMSO

Storage: -20 o C.

Restrictions: For Research Use only

Publications

Product: Fan, Li, Levy et al.: "Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 10, pp. 6573-80, 2007 (PubMed).

Xiang, Yin, Li et al.: "Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase." in: American journal of respiratory cell and molecular biology, Vol. 44, Issue 3, pp. 333-40, 2011 (PubMed).