Akt Inhibitor

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Application
Functional Studies (Func), Cell Culture (CC), Blocking Antibody (Inhibition)
Pubmed 2 references available
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Quantity 1 mg
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Characteristics Potent inhibitor of Akt (PKB) (IC50 = 2 µM). Weak inhibitor of phosphatidylinositol 3-kinase (PI3-K) (IC50 = 83 µM). Has been shown to inhibit the growth of the following cancer cell lines: HeLa (IC50 = 2.5 µM), HT-29 (IC50 = 10 µM), MCF-7 (IC50 = 1.2 µM), and PC-3 (IC50 = 2.0 µM).
Purity 98,00 %
Molecular Weight 578.8 Da
Restrictions For Research Use only
Format Solid
Reconstitution Solubility: Soluble in DMSO
Handling Advice Protect from air and moisture.
Storage -20 °C
Expiry Date 12 months
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Image no. 1 for Akt Inhibitor (ABIN412306) Akt Inhibitor
Product cited in: Xiang, Yin, Li et al.: "Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase." in: American journal of respiratory cell and molecular biology, Vol. 44, Issue 3, pp. 333-40, 2011 (PubMed).

Fan, Li, Levy et al.: "Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 10, pp. 6573-80, 2007 (PubMed).