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Caspase-1 Inhibitor Z-YVAD-FMK

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Application
Inhibition Assay (InhA), Functional Studies (Func), Enzyme Activity Assay (EAA)
Pubmed 9 references available
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Quantity 100 μL
Quantity Comment 2 mM
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Immunogen Sequence: Z-Tyr-Val-Ala-Asp-FMK (FMK, fluoromethyl ketone)
Sequence Z-Tyr-Val-Ala-Asp(OMe)-FMK
Characteristics PubChem CID: 16760349
Molecular Formula: C₃₁H₃₉FN₄O₉
Cell Premeable: Yes
Purity > 99 % by HPLC
Background Synonyms: Z-YVAD-FMK, Caspase-1 Inhibitor, Z-YVAD fluoromethylketone
Molecular Weight 630,7 g/mol
Application Notes We recommend using 1000X dilutions for inhibiting caspase-3 activity in Jurkat cell culture (e.g., Add 1 µL to 1 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Liquid
Reconstitution In DMSO (10 mM)
Concentration 10 mM
Buffer DMSO
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 6-12 months
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Image no. 1 for Caspase-1 Inhibitor Z-YVAD-FMK (ABIN412351) Caspase-1 Inhibitor Z-YVAD-FMK
Product cited in: Lhomme, Esser, Riva et al.: "Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages." in: Journal of lipid research, Vol. 54, Issue 11, pp. 2998-3008, 2013 (PubMed).

Shao: "Understanding the mechanisms of human tubal ectopic pregnancies: new evidence from knockout mouse models." in: Human reproduction (Oxford, England), Vol. 25, Issue 3, pp. 584-7, 2010 (PubMed).

Hewinson, Moore, Glover et al.: "A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 12, pp. 8410-20, 2008 (PubMed).

Arai, Miyake, Voit et al.: "Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 7, pp. 2289-94, 2007 (PubMed).

Cruz, Rinna, Forman et al.: "ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages." in: The Journal of biological chemistry, Vol. 282, Issue 5, pp. 2871-9, 2007 (PubMed).

Klumpp, Rycyk, Chen et al.: "Uropathogenic Escherichia coli induces extrinsic and intrinsic cascades to initiate urothelial apoptosis." in: Infection and immunity, Vol. 74, Issue 9, pp. 5106-13, 2006 (PubMed).

Lin, Cheung, Wu et al.: "15d-prostaglandin J2 protects brain from ischemia-reperfusion injury." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 26, Issue 3, pp. 481-7, 2006 (PubMed).

Gillet, Dewals, Farnir et al.: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

Yen, Mar, Craciunescu et al.: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." in: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).

Catalog No. ABIN412351
$165.00
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