Caspase-1 Inhibitor Z-YVAD-FMK

Details for Product No. ABIN412352
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Application
Inhibition Assay (InhA), Functional Studies (Func), Enzyme Activity Assay (EAA)
Pubmed 8 references available
Quantity 20 μL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN412352
132.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Sequence: Z-Tyr-Val-Ala-Asp-FMK (FMK, fluoromethyl ketone)
Sequence Z-Tyr-Val-Ala-Asp(OMe)-FMK
Characteristics PubChem CID: 16760349
Molecular Formula: C₃₁H₃₉FN₄O₉
Cell Premeable: Yes
Purity > 99 % by HPLC
Background Synonyms: Z-YVAD-FMK, Caspase-1 Inhibitor, Z-YVAD fluoromethylketone
Molecular Weight 630,7 g/mol
Application Notes We recommend using 1000X dilutions for inhibiting caspase-3 activity in Jurkat cell culture (e.g., Add 1 µL to 1 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Liquid
Reconstitution In DMSO (10 mM)
Concentration 10 mM
Buffer DMSO
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 6-12 months
Product cited in: Yen, Mar, Craciunescu et al.: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." in: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).

Gillet, Dewals, Farnir et al.: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

Lin, Cheung, Wu et al.: "15d-prostaglandin J2 protects brain from ischemia-reperfusion injury." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 26, Issue 3, pp. 481-7, 2006 (PubMed).

Klumpp, Rycyk, Chen et al.: "Uropathogenic Escherichia coli induces extrinsic and intrinsic cascades to initiate urothelial apoptosis." in: Infection and immunity, Vol. 74, Issue 9, pp. 5106-13, 2006 (PubMed).

Cruz, Rinna, Forman et al.: "ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages." in: The Journal of biological chemistry, Vol. 282, Issue 5, pp. 2871-9, 2007 (PubMed).

Arai, Miyake, Voit et al.: "Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 7, pp. 2289-94, 2007 (PubMed).

Hewinson, Moore, Glover et al.: "A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 12, pp. 8410-20, 2008 (PubMed).

Shao: "Understanding the mechanisms of human tubal ectopic pregnancies: new evidence from knockout mouse models." in: Human reproduction (Oxford, England), Vol. 25, Issue 3, pp. 584-7, 2010 (PubMed).

Validation Images
back to top