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Caspase-9 Inhibitor Z-LEHD-FMK

Details for Product No. ABIN412392
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Application
Functional Studies (Func), Enzyme Activity Assay (EAA)
Pubmed 12 references available
Quantity 100 µL
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Catalog No. ABIN412392
132.00 $
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Immunogen Sequence: Z-Leu-Glu-His-Asp-FMK (FMK, fluoromethyl ketone)
Sequence Z-Leu-Glu(OMe)-His-Asp(OMe)-FMK
Purity > 98 % by HPLC
Background A synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Molecular Weight 690.7 Da
Application Notes We recommend using 1000X dilutions for inhibiting caspase-9 activity in cell culture (e.g., Add 1 µL to 1 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Liquid
Concentration 2 mM
Buffer DMSO
Handling Advice Protect from light and moisture.
Storage -20 °C
Expiry Date 12 months
Product cited in: Chatterjee, Brite, Matsumura: "Induction of apoptosis of integrin-expressing human prostate cancer cells by cyclic Arg-Gly-Asp peptides." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 7, Issue 10, pp. 3006-11, 2001 (PubMed).

Morishima, Nakanishi, Takenouchi et al.: "An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12." in: The Journal of biological chemistry, Vol. 277, Issue 37, pp. 34287-94, 2002 (PubMed).

Yen, Mar, Craciunescu et al.: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." in: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).

Beaupre, Cepero, Obeng et al.: "R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways." in: Molecular cancer therapeutics, Vol. 3, Issue 2, pp. 179-86, 2004 (PubMed).

Song, Zhou, Kim et al.: "Carbon monoxide promotes Fas/CD95-induced apoptosis in Jurkat cells." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 44327-34, 2004 (PubMed).

Wang, Grégori, Hullinger et al.: "Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression." in: Molecular and cellular biology, Vol. 24, Issue 23, pp. 10352-65, 2004 (PubMed).

Yao, Nguyen, Pike: "Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, Issue 5, pp. 1149-58, 2005 (PubMed).

Gillet, Dewals, Farnir et al.: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

Deng, Yin, Lu et al.: "The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 91, Issue 1, pp. 59-69, 2006 (PubMed).

Teachey, Obzut, Axsom et al.: "Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)." in: Blood, Vol. 108, Issue 6, pp. 1965-71, 2006 (PubMed).

Jin, Ojcius, Sun et al.: "Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways." in: Infection and immunity, Vol. 77, Issue 2, pp. 799-809, 2009 (PubMed).

Chuang, Lin, Tai et al.: "Preferential involvement of mitochondria in Toll-like receptor 3 agonist-induced neuroblastoma cell apoptosis, but not in inhibition of cell growth." in: Apoptosis : an international journal on programmed cell death, 2011 (PubMed).

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