Caspase-9 Inhibitor Z-LEHD-FMK

Details for Product No. ABIN412393
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Application
Inhibition Assay (InhA), Functional Studies (Func), Enzyme Activity Assay (EAA)
Pubmed 12 references available
Quantity 20 μL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN412393
159.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Sequence: Z-Leu-Glu-His-Asp-FMK (FMK, fluoromethyl ketone)
Sequence Z-Leu-Glu(OMe)-His-Asp(OMe)-FMK
Characteristics PubChem CID: 44135217
Molecular Formula: C₃₂H₄₃FN₆O₁₀
Cell Premeable: Yes
Purity > 98 % by HPLC
Background Synonyms: Z-LEHD-FMK, Caspase-9 Inhibitor, LEHD-fluoromethylketone
Molecular Weight 690,7 g/mol
Application Notes Centrifuge the vial prior to opening. We recommend using 1000-5000X dilutions for inhibiting caspase-9 activity in cell culture (e.g., Add 1 µL to 1-5 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Liquid
Reconstitution In DMSO (10 mM)
Concentration 10 mM
Buffer DMSO
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 12 months
Product cited in: Chatterjee, Brite, Matsumura: "Induction of apoptosis of integrin-expressing human prostate cancer cells by cyclic Arg-Gly-Asp peptides." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 7, Issue 10, pp. 3006-11, 2001 (PubMed).

Morishima, Nakanishi, Takenouchi et al.: "An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12." in: The Journal of biological chemistry, Vol. 277, Issue 37, pp. 34287-94, 2002 (PubMed).

Yen, Mar, Craciunescu et al.: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." in: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).

Beaupre, Cepero, Obeng et al.: "R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways." in: Molecular cancer therapeutics, Vol. 3, Issue 2, pp. 179-86, 2004 (PubMed).

Song, Zhou, Kim et al.: "Carbon monoxide promotes Fas/CD95-induced apoptosis in Jurkat cells." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 44327-34, 2004 (PubMed).

Wang, Grégori, Hullinger et al.: "Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression." in: Molecular and cellular biology, Vol. 24, Issue 23, pp. 10352-65, 2004 (PubMed).

Yao, Nguyen, Pike: "Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, Issue 5, pp. 1149-58, 2005 (PubMed).

Gillet, Dewals, Farnir et al.: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

Deng, Yin, Lu et al.: "The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 91, Issue 1, pp. 59-69, 2006 (PubMed).

Teachey, Obzut, Axsom et al.: "Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)." in: Blood, Vol. 108, Issue 6, pp. 1965-71, 2006 (PubMed).

Jin, Ojcius, Sun et al.: "Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways." in: Infection and immunity, Vol. 77, Issue 2, pp. 799-809, 2009 (PubMed).

Ying, Yang, Tsai et al.: "Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway." in: Archives of toxicology, 2011 (PubMed).

Validation Images
back to top