Caspase-12 Inhibitor

Details for Product No. ABIN412400
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Application
Functional Studies (Func), Enzyme Activity Assay (EAA)
Pubmed 5 references available
Quantity 100 µL
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Catalog No. ABIN412400
159.50 $
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Immunogen Sequence: Z-Ala-Thr-Ala-Asp(OMe)-FMK (FMK, fluoromethyl ketone)
Sequence Z-Ala-Thr-Ala-Asp(OMe)-FMK
Purity > 95 % by HPLC
Background A synthetic peptide that irreversibly inhibits caspase-12 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Molecular Weight 540.54 Da
Application Notes We recommend using 1000X dilutions for inhibiting caspase-12 activity in tissue and cell lysate (Add 1 µL to 1 mL of tissue and cell lysate). The optimal doses may vary for different tissue and cell preparations.
Restrictions For Research Use only
Format Liquid
Concentration 2 mM
Buffer DMSO
Handling Advice Protect from light and moisture.
Storage -20 °C
Expiry Date 12 months
Product cited in: Ou, Wu, Ip et al.: "Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response." in: Journal of lipid research, Vol. 49, Issue 5, pp. 985-94, 2008 (PubMed).

Fu, Minamino, Tsukamoto et al.: "Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition." in: Cardiovascular research, Vol. 79, Issue 4, pp. 600-10, 2008 (PubMed).

Trisciuoglio, Uranchimeg, Cardellina et al.: "Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide." in: Journal of the National Cancer Institute, Vol. 100, Issue 17, pp. 1233-46, 2008 (PubMed).

Bian, Elner, Elner: "Regulated expression of caspase-12 gene in human retinal pigment epithelial cells suggests its immunomodulating role." in: Investigative ophthalmology & visual science, Vol. 49, Issue 12, pp. 5593-601, 2008 (PubMed).

Zeng, Li, He et al.: "Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes." in: Molecular cancer research : MCR, Vol. 9, Issue 12, pp. 1708-17, 2011 (PubMed).

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