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Caspase-12 Inhibitor, Z-ATAD-FMK

Details for Product No. ABIN412401, Supplier: Log in to see
Application
Enzyme Activity Assay (EAA), Functional Studies (Func), Inhibition Assay (InhA)
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Immunogen Sequence: Z-Ala-Thr-Ala-Asp(OMe)-FMK (FMK, fluoromethyl ketone)
Sequence Z-Ala-Thr-Ala-Asp(OMe)-FMK
Characteristics PubChem CID: N/A
Molecular Formula: C₂₄H₃₃N₄O₉F
Cell Premeable: Yes
Purity > 95 % by HPLC
Background Synonyms: Z-ATAD-FMK, Caspase-12 Inhibitor, Z-ATAD-fluoromethylketone
Molecular Weight 540,54 g/mol
Application Notes We recommend using up to 1000-5000X dilutions for inhibiting caspase-12 activity in cell culture (e.g., Add 1 µL to 1 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Liquid
Reconstitution In DMSO (10 mM)
Concentration 10 mM
Buffer DMSO
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 12 months
Product cited in: Zeng, Li, He et al.: "Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes." in: Molecular cancer research : MCR, Vol. 9, Issue 12, pp. 1708-17, 2011 (PubMed).

Bian, Elner, Elner: "Regulated expression of caspase-12 gene in human retinal pigment epithelial cells suggests its immunomodulating role." in: Investigative ophthalmology & visual science, Vol. 49, Issue 12, pp. 5593-601, 2008 (PubMed).

Trisciuoglio, Uranchimeg, Cardellina et al.: "Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide." in: Journal of the National Cancer Institute, Vol. 100, Issue 17, pp. 1233-46, 2008 (PubMed).

Fu, Minamino, Tsukamoto et al.: "Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition." in: Cardiovascular research, Vol. 79, Issue 4, pp. 600-10, 2008 (PubMed).

Ou, Wu, Ip et al.: "Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response." in: Journal of lipid research, Vol. 49, Issue 5, pp. 985-94, 2008 (PubMed).