Caspase-5 Inhibitor Z-WEHD-FMK

Details for Product No. ABIN412402
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Application
Functional Studies (Func), Enzyme Activity Assay (EAA)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN412402
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Immunogen Sequence: Z-Trp-Glu-His-Asp-FMK (FMK, fluoromethyl ketone)
Sequence Z-Trp-Glu(OMe)-His-Asp(OMe)-FMK
Purity > 99 % by HPLC
Background A synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Molecular Weight 763.78 Da
Application Notes We recommend using 1000X dilutions for inhibiting caspase-3 activity in Jurkat cell culture (e.g., Add 1 µL to 1 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Liquid
Concentration 2 mM
Buffer DMSO
Handling Advice Protect from light and moisture.
Storage -20 °C
Expiry Date 12 months
Product cited in: Coletti, Yang, Marazzi et al.: "TNFalpha inhibits skeletal myogenesis through a PW1-dependent pathway by recruitment of caspase pathways." in: The EMBO journal, Vol. 21, Issue 4, pp. 631-42, 2002 (PubMed).

Gillet, Dewals, Farnir et al.: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

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