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Caspase-5 Inhibitor Z-WEHD-FMK

Details for Product No. ABIN412402, Supplier: Log in to see
Application
Enzyme Activity Assay (EAA), Functional Studies (Func), Inhibition Assay (InhA)
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Immunogen Sequence: Z-Trp-Glu-His-Asp-FMK (FMK, fluoromethyl ketone)
Sequence Z-Trp-Glu(OMe)-His-Asp(OMe)-FMK
Characteristics PubChem CID: 44134610
Molecular Formula: C₃₇H₄₂FN₇O₁₁
Cell Premeable: Yes
Purity > 99 % by HPLC
Background Synonyms: Z-WEHD-FMK, Caspase-5 Inhibitor (fluoromethylketone)
Molecular Weight 763,78 g/mol
Application Notes We recommend using 1000-5000X dilutions for inhibiting caspase-5 activity in Jurkat cell culture (e.g., Add 1 µL to 1-5 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Liquid
Reconstitution In DMSO (10 mM)
Concentration 10 mM
Buffer DMSO
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 12 months
Product cited in: Burm, Zuiderwijk-Sick, t Jong et al.: "Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 2, pp. 678-87, 2015 (PubMed).

Gillet, Dewals, Farnir et al.: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

Coletti, Yang, Marazzi et al.: "TNFalpha inhibits skeletal myogenesis through a PW1-dependent pathway by recruitment of caspase pathways." in: The EMBO journal, Vol. 21, Issue 4, pp. 631-42, 2002 (PubMed).